Psychopharmacology

, Volume 222, Issue 4, pp 609–617

Age modulates the effect of COMT genotype on delay discounting behavior

Original Investigation

Abstract

Rationale and objective

A form of impulsivity, the tendency to choose immediate over delayed rewards (delay-discounting) has been associated with a single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene (COMTval158met; rs4680). However, the existing data regarding the nature of this association are in conflict. We have previously reported that adults homozygous for valine (val) at the COMTval158met SNP demonstrate greater delay-discounting than do methionine (met) allele carriers (Boettiger et al., J Neurosci 27:14383–14391, 2007). In contrast, a recent study of adolescent males found that those with the met/met genotype demonstrate greater delay-discounting than do val-allele carriers (Paloyelis et al., Neuropsychopharmacology 35:2414–2426, 2010). Based on reported age-related changes in frontal dopamine function and COMT expression, we hypothesized that the association of COMT genotype with delay-discounting behavior is modulated by age from late adolescence to young adulthood.

Methods

To test this hypothesis, we genotyped late adolescents (18–21 years; n = 72) and adults (22–40 years; n = 70) for the COMTval158met polymorphism, measured their delay-discounting behavior, and tested for an interaction between age group and COMT genotype.

Results

This cross-sectional study found that age modulates COMTval158met genotype effects on delay-discounting behavior. Among met-carriers, delay-discounting was negatively correlated with age from late adolescence to adulthood, while among val/val individuals delay-discounting was positively correlated with age across this range.

Conclusions

These results confirm our previous finding of enhanced delay-discounting among val/val adults relative to met-allele carriers, and help reconcile existing literature. We propose a single U-shaped model of the relationship between frontal DA levels and impulsive choice that accounts for both adolescent and adult data.

Keywords

Adolescence Decision-making Delay discounting Development Dopamine Impulsivity 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Christopher T. Smith
    • 1
  • Charlotte A. Boettiger
    • 1
    • 2
  1. 1.Neurobiology CurriculumUniversity of North CarolinaChapel HillUSA
  2. 2.Department of Psychology, Biomedical Research Imaging Center, and Bowles Center for Alcohol StudiesUniversity of North CarolinaChapel HillUSA

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