Psychopharmacology

, Volume 226, Issue 4, pp 739–746 | Cite as

A randomized, placebo-controlled laboratory study of the effects of d-cycloserine on craving in cocaine-dependent individuals

  • Kimber L. Price
  • Nathaniel L. Baker
  • Aimee L. McRae-Clark
  • Michael E. Saladin
  • Stacia M. DeSantis
  • Elizabeth J. Santa Ana
  • Kathleen T. Brady
Original Investigation

Abstract

Rationale

d-Cycloserine (DCS), a partial glutamate N-methyl-d-aspartate (NMDA) receptor agonist, enhances extinction of conditioned fear responding; preliminary data suggest that it may facilitate extinction of drug cue reactivity.

Objective

This study investigates DCS effects on cocaine cue craving and drug use in cocaine-dependent subjects.

Methods

Thirty-two subjects were randomly assigned to receive (1) DCS only, (2) DCS before sessions 1 and 3, placebo (PBO) before session 2, or (3) PBO only 15-min before each of 3 1-h cocaine cue exposure sessions conducted 1 day apart. Craving ratings were obtained before, during, and after sessions. Drug use and cue-induced craving were assessed 1 week after the last cue session.

Results

Repeated presentation of cocaine cues resulted in decreased craving both within and between sessions. DCS did not facilitate extinction learning and may have enhanced craving. The group that received three doses of DCS had significantly higher craving than the PBO group at the baseline ratings taken before sessions 2 and 3, as well as significantly higher cue-induced craving at follow-up. The group that received two doses of DCS did not differ from the PBO group. There were no group differences in postextinction cocaine use.

Conclusions

The reduction of cocaine cue reactivity in the PBO group suggests that the study procedures were sufficient to produce extinction. Under these conditions, DCS did not facilitate extinction and may have enhanced craving. Further studies of glutamatergic agents and extinction in cocaine dependence should include consideration of procedural variables that could have a major impact on study outcomes.

Keywords

Cocaine Craving Cue reactivity Extinction Reconsolidation d-Cycloserine 

Notes

Acknowledgments

This study was supported by the National Institutes of Health (Grant Nos. 1R01DA023188-01A1 and 3R01DA023188-02S1). The authors thank Lisa Jenkins, Katherine Shugart, Colleen Reed, and Cullen McWhite at MUSC and Elizabeth Chapman and Margaret Garret at BHSPC for their assistance with study participants. Preliminary analyses of these data were presented in poster format at the 2010 College on Problems of Drug Dependence annual meeting in Scottsdale, AZ.

Conflicts of interest

None

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Kimber L. Price
    • 1
    • 4
  • Nathaniel L. Baker
    • 2
  • Aimee L. McRae-Clark
    • 1
  • Michael E. Saladin
    • 3
  • Stacia M. DeSantis
    • 2
  • Elizabeth J. Santa Ana
    • 1
  • Kathleen T. Brady
    • 1
  1. 1.Department of Psychiatry and Behavioral Sciences, Division of Clinical NeuroscienceMedical University of South CarolinaCharlestonUSA
  2. 2.Department of Medicine, Division of Biostatistics and EpidemiologyMedical University of South CarolinaCharlestonUSA
  3. 3.Department of Health Sciences and ResearchMedical University of South CarolinaCharlestonUSA
  4. 4.CharlestonUSA

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