Measuring impulsivity in mice: the five-choice serial reaction time task
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Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented.
This study aims to summarise the main results of the 5CSRTT in mice, with special focus on impulsivity.
The 5CSRTT can be used to explore aspects of both attentional and inhibitory control mechanisms.
Different manipulations of the task parameters can lead to different results; adjusting the protocol as a function of the main variable of interest or the standardisation of the protocol to be applied to a large set of strains will be desirable.
The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice.
KeywordsFive-choice serial reaction time task Impulsivity Attention Task parameters Mice
Work in Stephens’ lab during the writing of this review was supported by MRC grant G1000008, EU FP7 grant “IMAGEN”, and EU InterReg grant “AlcoBinge”. This paper reflects only the authors’ views and the Community is not liable for any use that may be made of the information contained therein.
Conflict of interest
The authors declare no conflict of interest.
- Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25:239–252PubMedCrossRefGoogle Scholar
- Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci 31:7264–7274PubMedCrossRefGoogle Scholar
- Carli M, Robbins TW, Evenden JL, Everitt BJ (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 9:361–380PubMedCrossRefGoogle Scholar
- Crawley JN, Belknap JK, Collins A, Crabbe JC, Frankel W, Henderson N, Hitzemann RJ, Maxson SC, Miner LL, Silva AJ, Wehner JM, Wynshaw-Boris A, Paylor R (1997) Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) 132:107–124CrossRefGoogle Scholar
- Dalley JW, Laane K, Theobald DE, Pena Y, Bruce CC, Huszar AC, Wojcieszek M, Everitt BJ, Robbins TW (2007) Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine. Neuropsychopharmacology 32:1195–1206PubMedCrossRefGoogle Scholar
- Duka T, Trick L, Nikolaou K, Gray MA, Kempton MJ, Williams H, Williams SC, Critchley HD, Stephens DN (2011) Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics. Biol Psychiatry. doi: 10.1016/j.biopsych.2011.04.006
- Humby T, Wilkinson L, Dawson G (2005) Assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. Curr Protoc Neurosci Chapter 8: Unit 8 5HGoogle Scholar
- Kerr LE, McGregor AL, Amet LE, Asada T, Spratt C, Allsopp TE, Harmar AJ, Shen S, Carlson G, Logan N, Kelly JS, Sharkey J (2004) Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia. Cell Death Differ 11:1102–1111PubMedCrossRefGoogle Scholar
- Loos M, Staal J, Schoffelmeer AN, Smit AB, Spijker S, Pattij T (2010) Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine. Behav Brain Res 214:216–224PubMedCrossRefGoogle Scholar
- Peña-Oliver Y, Buchman V, Dalley J, Robbins TW, Schumann G, Ripley T, King S, Stephens D (2011) Deletion of alpha-synuclein decreases impulsivity in mice. Genes, Brain and Behaviour (in press)Google Scholar
- Walker SE, Peña-Oliver Y, Stephens DN (2011) Learning not to be impulsive: disruption by experience of alcohol withdrawal. Psychopharmacology (Berl) 217(3):433–442Google Scholar