Psychopharmacology

, Volume 220, Issue 4, pp 799–807 | Cite as

The acute effects of 3,4-methylenedioxymethamphetamine and d-methamphetamine on human cognitive functioning

  • Con Stough
  • Rebecca King
  • Katherine Papafotiou
  • Phillip Swann
  • Edward Ogden
  • Keith Wesnes
  • Luke A. Downey
Original Investigation

Abstract

Rationale

This study investigated the acute (3-h) and 24-h post-dose cognitive effects of oral 3,4-methylenedioxymethamphetamine (MDMA), d-methamphetamine, and placebo in a within-subject double-blind laboratory-based study in order to compare the effect of these two commonly used illicit drugs on a large number of recreational drug users.

Methods

Sixty-one abstinent recreational users of illicit drugs comprised the participant sample, with 33 females and 28 males, mean age 25.45 years. The three testing sessions involved oral consumption of 100 mg MDMA, 0.42 mg/kg d-methamphetamine, or a matching placebo. The drug administration was counter-balanced, double-blind, and medically supervised. Cognitive performance was assessed during drug peak (3 h) and at 24 h post-dosing time-points. Blood samples were also taken to quantify the levels of drug present at the cognitive testing time-points.

Results

Blood concentrations of both methamphetamine and MDMA at drug peak samples were consistent with levels observed in previous studies. The major findings concern poorer performance in the MDMA condition at peak concentration for the trail-making measures and an index of working memory (trend level), and more accurate performance on a choice reaction task within the methamphetamine condition. Most of the differences in performance between the MDMA, methamphetamine, and placebo treatments diminished by the 24-h testing time-point, although some performance improvements subsisted for choice reaction time for the methamphetamine condition.

Conclusions

Further research into the acute effects of amphetamine preparations is necessary to further quantify the acute disruption of aspects of human functioning crucial to complex activities such as attention, selective memory, and psychomotor performance.

Keywords

MDMA Ecstasy Methamphetamine Cognition Memory Psychomotor CDR 

Notes

Acknowledgements

This study was funded by an Australian Research Council Grant to Professor Con Stough, Katherine Papafotiou and Edward Ogden: Grant DP0772762.

References

  1. Back-Madruga C, Boone KB, Chang L, Grob CS, Lee A, Nations H, Poland RE (2003) Neuropsychological effects of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) in recreational users. Clin Neuropsychol 17:446–459PubMedCrossRefGoogle Scholar
  2. Bosker WM, Kuypers KPC, Conen S, Ramaekers JG (2010) Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss. Psychopharmacology: 1–8Google Scholar
  3. Busto U, Bendayan R, Sellers EM (1989) Clinical pharmacokinetics of non-opiate abused drugs. Clin Pharmacokin 16:1–26CrossRefGoogle Scholar
  4. Clemens KJ, McGregor IS, Hunt GE, Cornish JL (2007) MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. Drug Alcohol Rev 26:9–15PubMedCrossRefGoogle Scholar
  5. Cole J, Sumnall H, Grob C (2002) Sorted: ecstasy facts and fiction. Psychologist 15:464–467Google Scholar
  6. Cruickshank CC, Dyer KR (2009) A review of the clinical pharmacology of methamphetamine. Addiction 104:1085–1099PubMedCrossRefGoogle Scholar
  7. Degenhardt L, Barker B, Topp L (2004) Patterns of ecstasy use in Australia: findings from a national household survey. Addiction 99:187–195PubMedCrossRefGoogle Scholar
  8. Degenhardt L, Coffey C, Carlin JB, Moran P, Patton GC (2007) Who are the new amphetamine users? A 10-year prospective study of young Australians. Addiction 102:1269–1279PubMedCrossRefGoogle Scholar
  9. Dumont GJH, Schoemaker RC, Touw DJ, Sweep FCGJ, Buitelaar JK, Van Gerven JMA, Verkes RJ (2010) Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers. J Psychopharmacol 24:155–164PubMedCrossRefGoogle Scholar
  10. Fernández-Serrano MJ, Pérez-García M, Verdejo-García A (2011) What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance? Neurosci Biobehav R 35:377–406CrossRefGoogle Scholar
  11. Giovagnoli AR, Del Pesce M, Mascheroni S, Simoncelli M, Laiacona M, Capitani E (1996) Trail making test: normative values from287 normal adult controls. Ital J Neurol Sci 17:305–309PubMedCrossRefGoogle Scholar
  12. Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev 55:463–508PubMedCrossRefGoogle Scholar
  13. Hart CL, Gunderson EW, Perez A, Kirkpatrick MG, Thurmond A, Comer SD, Foltin RW (2008) Acute physiological and behavioral effects of intranasal methamphetamine in humans. Neuropsychopharmacol 33:1847–1855CrossRefGoogle Scholar
  14. Johnson BA, Ait-Daoud N, Wells LT (2000) Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced cognitive and physiological changes in humans. Neuropsychopharmacol 22:504–512CrossRefGoogle Scholar
  15. Kalechstein AD, Newton TF, Green M (2003) Methamphetamine dependence is associated with neurocognitive impairment in the initial phases of abstinence. J Neuropsychi Clin N 15:215–220CrossRefGoogle Scholar
  16. Kalechstein AD, De La Garza Ii R, Mahoney Iii JJ, Fantegrossi WE, Newton TF (2007) MDMA use and neurocognition: a meta-analytic review. Psychopharmacology 189:531–537PubMedCrossRefGoogle Scholar
  17. Kuypers KPC, Ramaekers JG (2005) Transient memory impairment after acute dose of 75 mg 3.4-methylenedioxymethamphetamine. J Psychopharmacol 19:633–639PubMedCrossRefGoogle Scholar
  18. Kuypers KPC, Ramaekers JG (2007) Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected. Psychopharmacol 189:557–563Google Scholar
  19. Lamers CTJ, Ramaekers JG, Muntjewerff ND, Sikkema KL, Samyn N, Read NL, Brookhuis KA, Riedel WJ (2003) Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performance. J Psychopharmacol 17:379–387PubMedCrossRefGoogle Scholar
  20. Lamers CTJ, Rizzo M, Bechara A, Ramaekers J (2006) Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. Transportation Research Record, (1969), pp. 50–57. ISBN: 0309099781; 978-030909978-3Google Scholar
  21. Liechti ME, Vollenweider FX (2000) The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('ecstasy') in healthy volunteers. J Psychopharmacol 14:269–274PubMedCrossRefGoogle Scholar
  22. McCann UD, Mertl M, Eligulashvili V, Ricaurte GA (1999) Cognitive performance in (±) 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') users: a controlled study. Psychopharmacol 143:417–425CrossRefGoogle Scholar
  23. McCann UD, Peterson SC, Ricaurte GA (2007) The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users. Neuropsychopharmacol 32:1695–1706CrossRefGoogle Scholar
  24. Moon M, Do KS, Park J, Kim D (2007) Memory impairment in methamphetamine dependent patients. Int J Neurosci 117:1–9PubMedCrossRefGoogle Scholar
  25. Parrott AC (1999) Does cigarette smoking cause stress? Am Psychol 54:817–820PubMedCrossRefGoogle Scholar
  26. Parrott AC (2000) Human research on MDMA (3,4-methylenedioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change. Neuropsychobiology 42:17–24PubMedCrossRefGoogle Scholar
  27. Parrott AC, Gibbs A, Scholey AB, King R, Owens K, Swann P, Ogden E, Stough C (2011) MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study. Psychopharmacology: 1–10Google Scholar
  28. Pirona A, Morgan MJ (2010) An investigation of the subacute effects of ecstasy on neuropsychological performance, sleep and mood in regular ecstasy users. J Psychopharmacol 24:175–185PubMedCrossRefGoogle Scholar
  29. Ramaekers JG, Kuypers KPC (2006) Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol. Neuropsychopharmacol 31:1048–1055CrossRefGoogle Scholar
  30. Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey L, Kure C, Lloyd J, Stough C (2008) An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol 22:553–562PubMedCrossRefGoogle Scholar
  31. Salo R, Nordahl TE, Galloway GP, Moore CD, Waters C, Leamon MH (2009) Drug abstinence and cognitive control in methamphetamine-dependent individuals. J Subst Abuse Treat 37:292–297PubMedCrossRefGoogle Scholar
  32. Scott JC, Woods SP, Matt GE, Meyer RA, Heaton RK, Atkinson JH, Grant I (2007) Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychol Rev 17:275–297PubMedCrossRefGoogle Scholar
  33. Shappell SA, Kearns GL, Valentine JL, Neri DF, DeJohn CA (1996) Chronopharmacokinetics and chronopharmacodynamics of dextromethamphetamine in man. J Clin Pharmacol 36:1051–1063PubMedCrossRefGoogle Scholar
  34. Silber BY, Papafotiou K, Croft RJ, Ogden E, Swann P, Stough C (2005) The effects of dexamphetamine on simulated driving performance. Psychopharmacol 179:536–543CrossRefGoogle Scholar
  35. Silber BY, Croft RJ, Papafotiou K, Stough C (2006) The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance. Psychopharmacol 187:154–169CrossRefGoogle Scholar
  36. Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ (2008) Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res 22:1629–1634PubMedCrossRefGoogle Scholar
  37. Stough C, Downey LA, King R, Papafotiou K, Swann P, Ogden E (2011) The acute effects of 3,4-methylenedioxymethamphetamine and methamphetamine on driving: a simulator study. Accid Anal Prev. doi: 10.1016/j.aap.2011.08.017
  38. Thomasius R, Zapletalova P, Petersen K, Buchert R, Andresen B, Wartberg L, Nebeling B, Schmoldt A (2006) Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. J Psychopharmacol (Oxford, England) 20:211–225CrossRefGoogle Scholar
  39. Wesnes K, Pincock C (2002) Practice effects on cognitive tasks: a major problem? Lancet Neurol 1:473PubMedCrossRefGoogle Scholar
  40. Wesnes KA, Ward T, McGinty A, Petrini O (2000) The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacol 152:353–361CrossRefGoogle Scholar
  41. White SR (2002) Amphetamine toxicity. Sem Resp Crit Care M 23:27–36CrossRefGoogle Scholar
  42. Winstock AR, Griffiths P, Stewart D (2001) Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. Drug Alcohol Depen 64:9–17CrossRefGoogle Scholar
  43. Zakzanis KK, Campbell Z, Jovanovski D (2007) The neuropsychology of ecstasy (MDMA) use: a quantitative review. Human Psychopharm Clin 22:427–435CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Con Stough
    • 1
  • Rebecca King
    • 1
  • Katherine Papafotiou
    • 1
  • Phillip Swann
    • 1
  • Edward Ogden
    • 3
  • Keith Wesnes
    • 2
  • Luke A. Downey
    • 1
  1. 1.Centre for Human PsychopharmacologySwinburne University of TechnologyHawthornAustralia
  2. 2.United BiosourceGoring-on-ThamesUK
  3. 3.Victoria PoliceMelbourneAustralia

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