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Psychopharmacology

, Volume 219, Issue 4, pp 1179–1181 | Cite as

The lack of effect of ziprasidone on platelet serotonin concentration in schizophrenic patients

  • Marina Sagud
  • Matea Nikolac
  • Alma Mihaljevic-Peles
  • Gordana Nedic
  • Bjanka Vuksan Cusa
  • Maja Mustapic
  • Miro Jakovljevic
  • Dorotea Muck-Seler
  • Nela PivacEmail author
Letter to the Editors

Ziprasidone is an atypical antipsychotic, with higher ratio of 5-HT2A/D2, 5-HT2C/D2 and 5-HT1A/D2 receptor binding than other antipsychotic drugs (Schmidt et al. 2001; Stahl and Shayegan 2007). It also blocks the serotonin transporter (5-HTT) and inhibits synaptic 5-HT reuptake (Tatsumi et al. 1999). Drugs that block the 5-HTT such as selective serotonin reuptake inhibitors (SSRI) have antidepressant properties, and ziprasidone is reported to have antidepressant effects in patients with depression (Moeller et al. 2007; Stahl and Shayegan 2007). At present, however, it is unknown whether ziprasidone affects the 5-HTT in vivo when given to patients in therapeutic doses. Platelet 5-HT concentration is a reliable marker of the 5-HTT blockade induced by SSRI, and reduced platelet 5-HT concentration is used as a marker of the biological activity of various SSRI (Muck-Seler et al. 2002). Therefore, the aim of the study was to investigate the effect of ziprasidone treatment on platelet 5-HT...

Keywords

Selective Serotonin Reuptake Inhibitor Ziprasidone Schizoaffective Disorder Selective Serotonin Reuptake Inhibitor Treatment Citrate Dextrose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Thanks are due to the psychiatric staff of the Clinical Hospital Centre Zagreb, Zagreb, Croatia. This work was supported by the Croatian Ministry of Science, Education and Sport (MSES), grants numbers 098-0982522-2455, 098-0922522-2457, 108-1083509-3513 and 108-1080037-0323. The comments in this work are solely the responsibility of the authors and do not necessarily represent the official views of the MSES. All protocols were approved by hospital review board and the Ethics Committee of the University Hospital Centre Zagreb and were therefore in line with the guidelines of the Declaration of Helsinki. There is no conflict of interest in relation to this article.

References

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Marina Sagud
    • 1
  • Matea Nikolac
    • 2
  • Alma Mihaljevic-Peles
    • 1
  • Gordana Nedic
    • 2
  • Bjanka Vuksan Cusa
    • 1
  • Maja Mustapic
    • 2
  • Miro Jakovljevic
    • 1
  • Dorotea Muck-Seler
    • 2
  • Nela Pivac
    • 2
    Email author
  1. 1.Department of Psychiatry, University Hospital Centre Zagreb, School of MedicineUniversity of ZagrebZagrebCroatia
  2. 2.Division of Molecular MedicineRudjer Boskovic InstituteZagrebCroatia

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