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Psychopharmacology

, Volume 219, Issue 1, pp 159–169 | Cite as

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

  • Evellyn Claudia Wietzikoski
  • Suelen Lúcio Boschen
  • Edmar Miyoshi
  • Mariza Bortolanza
  • Lucélia Mendes dos Santos
  • Michael Frank
  • Marcus Lira Brandão
  • Philip Winn
  • Claudio Da Cunha
Original Investigation

Abstract

Rationale

Aversively motivated learning is more poorly understood than appetitively motivated learning in many aspects, including the role of dopamine receptors in different regions of the striatum.

Objectives

The present study investigated the roles of the D1-like DA receptors in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) on learning and performance of conditioned avoidance responses (CARs).

Methods

Adult male Wistar rats received intraperitoneal (i.p.), intra-NAc, or intra-DLS injections of the D1 dopamine receptor agonist SKF 81297 or the D1 receptor antagonist SCH 23390 20 min before or immediately after a training session in the CAR task two-way active avoidance, carried out 24 h before a test session.

Results

Pre-training administration of SCH 23390, but not SKF 81297, caused a significant decrease in the number of CARs in the test, but not in the training session, when injected into the DLS, or in either session when injected into the NAc. It also caused a significant increase in the number of escape failures in the training session when injected into the NAc. Systemic administration caused a combination of these effects. Post-training administrations of these drugs caused no significant effect.

Conclusions

The results suggest that the D1-like receptors in the NAc and DLS play important, though different, roles in learning and performance of CAR.

Keywords

Dorsolateral striatum Nucleus accumbens D1 dopamine receptor Two-way active avoidance Conditioned avoidance learning Memory Decision-making 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Evellyn Claudia Wietzikoski
    • 1
  • Suelen Lúcio Boschen
    • 1
  • Edmar Miyoshi
    • 1
    • 2
  • Mariza Bortolanza
    • 1
  • Lucélia Mendes dos Santos
    • 1
  • Michael Frank
    • 3
  • Marcus Lira Brandão
    • 4
  • Philip Winn
    • 5
  • Claudio Da Cunha
    • 1
  1. 1.Departamento de FarmacologiaLaboratório de Fisiologia e Farmacologia do Sistema Nervoso CentraCuritibaBrazil
  2. 2.Departamento de Ciências FarmacêuticasUEPGPonta GrossaBrazil
  3. 3.Department of Cognitive, Linguistic and Psychological Sciences, Department of Psychiatry and Human Behavior, Brown Institute for Brain ScienceBrown UniversityProvidenceUSA
  4. 4.Instituto de Neurociencias e Comportamento – IneCRibeirão PretoBrazil
  5. 5.Strathclyde Institute of Pharmacy and Biomedical SciencesUniversity of StrathclydeGlasgowUK

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