Psychopharmacology

, Volume 217, Issue 4, pp 587–593

Variation in saliva cotinine as a function of self-reported attempts to reduce cigarette consumption

  • Jennifer A. Fidler
  • John A. Stapleton
  • Robert West
Original Investigation

Abstract

Rationale

Cotinine is an accurate objective marker of nicotine intake. There is very little information on its stability over time or as a function of self-reported attempts at smoking reduction.

Objectives

This study aimed to assess the stability of saliva cotinine concentrations over a 3-month period, as a function of self-reported attempts to reduce cigarette consumption, using data from a general population sample of English smokers.

Methods

Six-hundred and ninety-one smokers from a population sample of English smokers provided saliva samples for cotinine analysis on two occasions 3 months apart. Data on cigarette consumption, whether smokers reported that they were attempting to cut down consumption and concurrent use of nicotine replacement therapy (NRT), were also collected on both occasions.

Results

The ‘test–retest’ measure of cotinine stability was 0.76, and the simple correlation was 0.73. Smokers not using NRT who reported cutting down on one occasion but not the other showed a small reduction in cigarette consumption at the time they were cutting down (1.1 cig per day, p = 0.013) but no significant difference in saliva cotinine concentrations (mean reduction = 13.4 ng/ml, p = 0.39).

Conclusions

Saliva cotinine concentrations show moderate-to-high stability within subjects over a 3-month period. Smokers’ reports of attempting to cut down their smoking are associated with small daily cigarette consumption decreases but no detectable change in nicotine intake.

Keywords

Biomarkers Cotinine Cutting down Follow-up studies Smoking 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Jennifer A. Fidler
    • 1
  • John A. Stapleton
    • 1
  • Robert West
    • 1
  1. 1.Department of Epidemiology and Public Health, Health Behaviour Research CentreUniversity College LondonLondonUK

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