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Psychopharmacology

, Volume 217, Issue 1, pp 39–50 | Cite as

Dexamphetamine effects on separate constructs in the rubber hand illusion test

  • Matthew A. Albrecht
  • Mathew T. Martin-Iverson
  • Greg Price
  • Joseph Lee
  • Rajan Iyyalol
  • Flavie Waters
Original Investigation

Abstract

Rationale

Corporeal awareness is an integral component of self-consciousness and is distorted in several neurological and psychiatric disorders. Research regarding the neural underpinnings of corporeal awareness has made much progress recently using the rubber hand illusion (RHI) procedure. However, more studies are needed to investigate the possibility of several dissociable constructs related to the RHI specifically, and corporeal awareness generally.

Objectives

Considering dopamine’s involvement in many perceptual-motor learning processes, as well as its apparent relationship with disorders such as schizophrenia that are linked to body ownership disturbances, we gave 0.45 mg/kg dexamphetamine (a dopamine transporter reverser) to 20 healthy participants to examine the effects of increased dopamine transmission on the RHI.

Methods

The effect of dexamphetamine on separate quantitative constructs underlying RHI were examined including embodiment of rubber hand, loss of ownership of real hand, perception of movement, affect, deafference, and proprioceptive drift. The experiment was a double-blind, placebo-controlled, cross-over design.

Results

Dexamphetamine increased participants’ ratings of embodiment (particularly “ownership”) of the rubber hand and was associated with the experience of loss of ownership of the person’s real hand. There were significant increases from asynchronous to synchronous stroking for the measures of movement and proprioceptive drift after placebo but not dexamphetamine. There were no changes in the measures of other constructs.

Conclusions

These results show a novel pharmacological manipulation of separate constructs of the RHI. This finding may aid in our understanding of disorders that have overlapping disturbances in both dopamine activity and body representations, particularly schizophrenia.

Keywords

Rubber hand illusion Embodiment Dopamine Noradrenaline Amphetamine Corporeal awareness 

Notes

Acknowledgements

This research was funded by a National Health and Medical Research Council grant (ID: 254619). Matthew Albrecht is the recipient of a Clinical Neurophysiology supplementary scholarship from the Department of Neurophysiology, North Metropolitan Area Health Service—Mental Health and the School of Medicine and Pharmacology of the University of Western Australia. Flavie Waters is recipient of Australian National Health and Medical Research Council (NHMRC) grants (ID: 404117; 634328).

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Matthew A. Albrecht
    • 1
    • 2
  • Mathew T. Martin-Iverson
    • 1
    • 2
    • 5
  • Greg Price
    • 3
    • 5
  • Joseph Lee
    • 3
    • 4
    • 5
  • Rajan Iyyalol
    • 4
  • Flavie Waters
    • 2
    • 3
  1. 1.Pharmacology and Anaesthesiology Unit, School of Medicine and PharmacologyThe University of Western AustraliaPerthAustralia
  2. 2.Centre for Clinical Research in Neuropsychiatry, CCRNGraylands HospitalClaremontAustralia
  3. 3.School of Psychiatry and Clinical NeurosciencesThe University of Western AustraliaPerthAustralia
  4. 4.Graylands HospitalPerthAustralia
  5. 5.Statewide Neurophysiology DepartmentGraylands HospitalPerthAustralia

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