Psychopharmacology

, Volume 214, Issue 3, pp 579–592

An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect

Review

DOI: 10.1007/s00213-010-2069-3

Cite this article as:
Lindson, N. & Aveyard, P. Psychopharmacology (2011) 214: 579. doi:10.1007/s00213-010-2069-3

Abstract

Rationale

Using nicotine replacement therapy (NRT) whilst smoking, prior to quitting, is called preloading. Two reviews have estimated the effect of preloading on abstinence, but need updating. Neither investigated possible mediators or moderators of the effect, which could have implications for individual treatment plans.

Objectives

To update the nicotine preloading efficacy estimate and test four hypotheses: (1) Efficacy is mediated through reduced smoking reward, (2) efficacy is mediated through increased NRT adherence post-quit, (3) efficacy is mediated through increased confidence, and (4) behavioural support modifies efficacy.

Methods

Randomised controlled trials were included that allocated cigarette smokers attempting to quit to either a preloading or control condition. A Mantel–Haenszel fixed-effect model was used to calculate risk ratios from quit rates at short- and long-term follow-ups. We carried out sub-group analyses and synthesised the data available on possible mediators and moderators qualitatively.

Results

Eight relevant studies were included, with 2,813 participants. The risk ratio (RR) for short-term abstinence was 1.05, 95% confidence intervals (CI) = 0.92, 1.19, and for long-term abstinence 1.16, 95% CI = 0.97, 1.38. There was a marginal benefit of using nicotine patch rather than gum for preloading, significant at short-term follow-up, and no significant benefit of more intensive pre-quit behavioural support.

Conclusions

We found a weak non-significant effect of nicotine preloading on abstinence. None of our mediational hypotheses received strong support, however evidence suggests that efficacy was enhanced by the patch over acute NRT. Future research needs to investigate the mechanisms of preloading by carrying out mediational analysis.

Keywords

Meta-analysis Systematic review Cigarette smoking Nicotine dependence Preloading Nicotine replacement therapy Smoking cessation Treatment efficacy Pre-cessation treatment 

Supplementary material

213_2010_2069_MOESM1_ESM.doc (27 kb)
ESM 1(DOC 27 kb)
213_2010_2069_MOESM2_ESM.doc (26 kb)
ESM 2(DOC 26 kb)

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.UK Centre for Tobacco Control Studies, Primary Care Clinical SciencesUniversity of BirminghamBirminghamUK

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