Psychopharmacology

, Volume 210, Issue 4, pp 511–519

Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adults

  • Nirit Agay
  • Eldad Yechiam
  • Ziv Carmel
  • Yechiel Levkovitz
Original Investigation

Abstract

Introduction

The effect of a single dose of methylphenidate (MPH) on cognitive measures and decision-making processes was assessed in a sample of adults with ADHD and in a control sample.

Methods

Thirty-two adults satisfying DSM-IV criteria for ADHD and 26 healthy controls performed several cognitive tasks. Half of the participants received MPH prior to performing the tasks, and the other half received placebo in a randomized, double-blind manner.

Results

The average digit-span test score was higher in the groups receiving MPH compared to the groups receiving placebo, while diagnosis did not have an effect upon scores. In decision-making tasks, however, MPH did not have an effect upon performance, whereas in one of the tasks the average proportion of risky choices was higher in ADHD adults compared to controls.

Conclusion

Our data therefore demonstrates that (a) MPH is capable of enhancing specific aspects of cognitive performance and (b) this enhancement is not specific to ADHD.

Keywords

Developmental disorder Behavioral assessment Decision-making Memory Attention 

Supplementary material

213_2010_1853_MOESM1_ESM.doc (37 kb)
ESM1(DOC 37kb)

References

  1. Arnsten AF (2006) Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways. J Clin Psychiatry 67:7–12CrossRefPubMedGoogle Scholar
  2. Asherson P (2005) Clinical assessment and treatment of attention deficit hyperactivity disorder in adults. Expert Rev Neurother 5:525–539CrossRefPubMedGoogle Scholar
  3. Barkley RA, Murphy KR, O'Connell T, Connor DF (2005) Effects of two doses of methylphenidate on simulator driving performance in adults with attention deficit hyperactivity disorder. J Safety Res 36(2):121–131CrossRefPubMedGoogle Scholar
  4. Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50:7–15CrossRefPubMedGoogle Scholar
  5. Bechara A, Damasio H, Damasio AR, Lee GP (1999) Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19:5473–5481PubMedGoogle Scholar
  6. Biederman J, Seidman LJ, Petty CR, Fried R, Doyle AE, Cohen DR, Kenealy DC, Faraone SV (2008) Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry 69:1150–1156CrossRefPubMedGoogle Scholar
  7. Boonstra AM, Kooij JJ, Oosterlaan J, Sergeant JA, Buitelaar JK (2005) Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD? J Clin Exp Neuropsychol 27(3):278–298CrossRefPubMedGoogle Scholar
  8. Busemeyer JR, Stout JC (2002) A contribution of cognitive decision models to clinical assessment: decomposing performance on the Bechara gambling task. Psychol Assess 14:253–262CrossRefPubMedGoogle Scholar
  9. Cooper NJ, Keage H, Hermens D, Williams LM, Debrota D, Clark CR, Gordon E (2005) The dose-dependent effect of methylphenidate on performance, cognition and psychophysiology. J Integr Neurosci 4(1):123–144CrossRefPubMedGoogle Scholar
  10. DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezseryb AM, Sahakian BJ (2008) The effects of methylphenidate on decision-making in attention-deficit/hyperactivity disorder. Biol Psychiatry 64:636–639CrossRefPubMedGoogle Scholar
  11. Elliott R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW (1997) Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology (Berl) 131:196–206CrossRefGoogle Scholar
  12. Gilman AG, Goodman LS, Gilman A (eds) (1980) Pharmacological basis of therapeutics. MacMillan, New YorkGoogle Scholar
  13. Greenberg LM, Kindschi CL (1996) TOVA clinical guide. Universal Attention Disorders, Los AlamitosGoogle Scholar
  14. Hervey AS, Epstein J, Curry JF (2004) The neuropsychology of adults with attention deficit hyperactivity disorder: a meta-analytic review. Neuropsychology 18:485–503CrossRefPubMedGoogle Scholar
  15. Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 111(1):1–16CrossRefGoogle Scholar
  16. Kurscheidt JC, Peiler P, Behnken A, Abel S, Pedersen A, Suslow T, Deckert J (2008) Acute effects of methylphenidate on neuropsychological parameters in adults with ADHD: possible relevance for therapy. J Neural Transm 115(2):357–362CrossRefPubMedGoogle Scholar
  17. Llorente AM, Amado AJ, Voigt RG, Berretta MC, Fraley JK, Heird WC (2001) Internal consistency, temporal stability, and reproducibility of individual index scores of the test of variables of attention in children with attention-deficit/hyperactivity disorder. Arch Clin Neuropsychol 16:535–546PubMedGoogle Scholar
  18. Lovasz L, Plummer MD (1986) Matching theory. North-Holland mathematics studies, vol 121. North-Holland, AmsterdamGoogle Scholar
  19. Malloy-Diniz L, Fuentes D, Leite WB, Correa H, Bechara A (2007) Impulsive behavior in adults with attention deficit/hyperactivity disorder: characterization of attentional, motor and cognitive impulsiveness. J Int Neuropsychol Soc 13:693–698CrossRefPubMedGoogle Scholar
  20. Marin RS, Fogel BS, Hawkins J, Duffy J, Krupp B (1995) Apathy: a treatable syndrome. J Neuropsychiatry Clin Neurosci 7:23–30PubMedGoogle Scholar
  21. McGough JJ, Barkley RA (2004) Diagnostic controversies in adult attention deficit hyperactivity disorder. Am J Psychiatry 161:1948–1956CrossRefPubMedGoogle Scholar
  22. McLean A, Dowson J, Toone B, Young S, Bazanis E, Robbins TW, Sahakian BJ (2004) Characteristic neurocognitive profile associated with adult attention-deficit/hyperactivity disorder. Psychol Med 34:681–692CrossRefPubMedGoogle Scholar
  23. Mehta MA, Sahakian BJ, Robbins TW (1999) Comparative psychopharmacology of methylphenidate and related drugs in human volunteers, patients with ADHD and experimental animals. In: Solanto MV, Arnsten AF, Castellanos FX (eds) Stimulant drugs and ADHD: basic and clinical neuroscience. Oxford University Press, New York, pp 303–331Google Scholar
  24. Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW (2000) Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci 20:RC65PubMedGoogle Scholar
  25. Mitler MM (1994) Evaluation of treatment with stimulants in narcolepsy. Sleep 17:103–106Google Scholar
  26. Rahman S, Robbins TW, Hodges JR, Mehta MA, Nestor PJ, Clark L, Sahakian BJ (2006) Methylphenidate (‘Ritalin’) can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia. Neuropsychopharmacology 31:651–658CrossRefPubMedGoogle Scholar
  27. Rapport LJ, Van Voorhis A, Tzelepis A, Friedman SR (2001) Executive functioning in adult attention-deficit hyperactivity disorder. Clin Neuropsychol 15:479–491PubMedGoogle Scholar
  28. Raven J (1989) The Raven progressive matrices: an overview of international norming studies. Psych Test Bull 2:7–16Google Scholar
  29. Riccio CA, Waldrop JJ, Reynolds CR, Lowe P (2001) Effects of stimulants on the continuous performance test (CPT): implications for CPT use and interpretation. J Neuropsychiatry Clin Neurosci 13(3):326–335PubMedGoogle Scholar
  30. Sahakian B, Morein-Zamir S (2007) Professor's little helper. Nature 450:1157–1159CrossRefPubMedGoogle Scholar
  31. Schweitzer JB, Lee DO, Hanford RB, Zink CF, Ely TD, Tagamets MA, Hoffman JM, Grafton ST, Kilts CD (2004) Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity. Biol Psychiatry 56:597–606CrossRefPubMedGoogle Scholar
  32. Seidman LJ (2006) Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev 26:466–485CrossRefPubMedGoogle Scholar
  33. Sevy S, Hassoun Y, Bechara A, Yechiam E, Napolitano B, Burdick K, Delman H, Malhotra A (2006) Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels. Psychopharmacology (Berl) 188:228–235CrossRefGoogle Scholar
  34. Swanson JM, Volkow N (2008) Increasing use of stimulants warns of potential abuse. Nature 453:586CrossRefPubMedGoogle Scholar
  35. Toplak ME, Jain U, Tannock R (2005) Executive and motivational processes in adolescents with attention-deficit-hyperactivity disorder (ADHD). Behav Brain Funct 1:8CrossRefPubMedGoogle Scholar
  36. Tucha O, Mecklinger L, Laufkötter R, Klein HE, Walitza S, Lange KW (2006) Methylphenidate-induced improvements of various measures of attention in adults with attention deficit hyperactivity disorder. J Neural Trans 113:1575–1592CrossRefGoogle Scholar
  37. Tucha L, Tucha O, Laufkotter R, Walitza S, Klein HE, Lange KW (2008) Neuropsychological assessment of attention in adults with different subtypes of attention-deficit/hyperactivity disorder. J Neural Trans 115:269–278CrossRefGoogle Scholar
  38. Turner DC, Blackwell AD, Dowson JH, McLean A, Sahakian BJ (2005) Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder. Psychopharmacology (Berl) 178:286–295CrossRefGoogle Scholar
  39. Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH, Gabrieli JD (1998) Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA 95:14494–14499CrossRefPubMedGoogle Scholar
  40. Volkow ND, Fowler JS, Wang G, Ding Y, Gatley SJ (2002) Mechanism of action of methylphenidate: insights from PET imaging studies. J Atten Disord Suppl 1:S31–43Google Scholar
  41. Volkow ND, Wang GJ, Fowler JS, Telang F, Maynard L, Logan J, Gatley SJ, Pappas N, Wong C, Vaska P, Zhu W, Swanson JM (2004) Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatry 161:1173–1180CrossRefPubMedGoogle Scholar
  42. Volkow ND, Fowler JS, Wang G-J, Telang F, Logan J, Wong C, Ma J, Pradhan K, Benveniste H, Swanson JM (2008) Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task. PLoS ONE 3:e2017CrossRefPubMedGoogle Scholar
  43. Wechsler D (1981) Manual for the wechsler adult intelligence Scale (Rev.). Psychological Corporation, New YorkGoogle Scholar
  44. Weiss M, Murray C (2003) Assessment and management of attention-deficit hyperactivity disorder in adults. Can Med Assoc J 168:715–722Google Scholar
  45. Weyandt LL, Rice JA, Linterman I, Mitzlaff L, Emert E (1998) Neuropsychological performance of a sample of adults with ADHD, developmental reading disorder, and controls. Dev Neuropsychol 14:643–656CrossRefGoogle Scholar
  46. Yechiam E, Stout JC, Busemeyer JR, Rock SL, Finn PR (2005) Individual differences in the response to forgone payoffs: an examination of high functioning drug abusers. J Behav Decis Making 18:97–110CrossRefGoogle Scholar
  47. Yechiam E, Busemeyer JR (2006) The effect of foregone payoffs on underweighting small probability events. J Behav Decis Making 19:1–16CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nirit Agay
    • 1
  • Eldad Yechiam
    • 1
  • Ziv Carmel
    • 2
    • 3
  • Yechiel Levkovitz
    • 2
    • 3
  1. 1.Israel Institute of TechnologyHaifaIsrael
  2. 2.Shalvata Mental Health CenterHod-HasharonIsrael
  3. 3.Tel-Aviv UniversityRamat-AvivIsrael

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