Reinforcing effects of nicotine and non-nicotine components of cigarette smoke
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Nicotine and non-nicotine components of cigarette smoke contribute to its reinforcing effects; however, the specific role of each component in maintaining behavior has not yet been elucidated.
To assess the reinforcing effects of nicotine and non-nicotine components of cigarette smoke by presenting a concurrent choice paradigm in which participants had access to intravenous (IV) nicotine infusions vs. saline (placebo) infusions and puffs from denicotinized (“denic”) cigarettes vs. air (sham puffs). We also measured the effects on self-administration of prior satiation with each component.
Sixteen smokers participated in seven sessions: 1) a baseline smoking assessment, used to tailor the nicotine dose per infusion; 2) two sessions for training discrimination of IV nicotine vs. saline infusions and denic smoke vs. sham puffs; and 3) four sessions assessing choice behavior after different satiation conditions.
Denic smoke was self-administered more than any other alternative, including IV nicotine. IV nicotine, however, was preferred over IV saline and sham puffs. Preference for denic smoke vs. IV nicotine was inversely correlated with subjective ratings of “comfort” associated with nicotine. Smoke satiation reduced the number of denic puffs taken during choice periods, while prior nicotine administration did not affect puffing behavior. Smoking withdrawal symptoms were alleviated both by nicotine administration and by denic smoke.
In established smokers, non-nicotine aspects of cigarette smoking have potent reinforcing effects. While current smoking cessation pharmacotherapies primarily address the nicotine component of cigarette addiction, future cessation strategies should also be designed to target non-nicotine factors.
KeywordsNicotine Addiction Reinforcement Self-administration
This study was supported by the National Institute on Drug Abuse grant DA02665.
- Benowitz NL, Porchet H, Jacob PI (1990) Pharmacokinetics, metabolism, and pharmacodynamics of nicotine. In: Wonnacott S, Russell MAH, Stolerman IP (eds) Nicotine Psychopharmacology. Oxford University Press, Oxford, pp 112–157Google Scholar
- Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Lawrence Erlbaum AssociatesGoogle Scholar
- Dallery J, Houtsmuller EJ, Pickworth WB, Stitzer ML (2003) Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking. Psychopharmacology (Berl) 165:172–180Google Scholar
- Donny EC, Chaudhri N, Caggiula AR, Evans-Martin FF, Booth S, Gharib MA, Clements LA, Sved AF (2003) Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement. Psychopharmacology (Berl) 169:68–76CrossRefGoogle Scholar
- Federal Trade Commission (2000) “Tar’, Nicotine and carbon monoxide of the smoke of 1294 varieties of domestic cigarettes for the year 1998Google Scholar
- Fiore MC, Bailey WC, Cohen SJea (2000) Treating tobacco use and dependence: clinical practice guideline. U.S. Department of Health and Human Services. Public Health Service, U.S. Department of Health and Human Services. Public Health ServiceGoogle Scholar
- Rose JE, Behm FM (1995) There is more to smoking than the CNS effects of nicotine. In: Clark PBS (ed) Effects of nicotine on biological systems II. Burkhäuser Verlag, Basel, pp 9–16Google Scholar
- Stevens J (1996) Applied Multivariate Statistics for the Social Sciences. Lawrence Erlbaum Associates, Lawrence Erlbaum AssociatesGoogle Scholar
- U.S.D.H.H.S. (1988) The health consequences of smoking: nicotine addiction. Office on Smoking and Health, Office on Smoking and HealthGoogle Scholar