Are attention lapses related to d-amphetamine liking?
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A rich literature suggests that both impulsiveness and drug-induced euphoria are risk factors for drug abuse. However, few studies have examined whether sensitivity to the euphoric effects of stimulants is related to attention lapses, a behavioral measure of inattention sometimes associated with impulsivity.
The aim of the study was to examine ratings of d-amphetamine drug liking among individuals with high, moderate, and low attention lapses.
Ninety-nine healthy volunteers were divided into three equal-sized groups based on their performance on a measure of lapses of attention. The groups, who exhibited low, medium, and high attention lapses (i.e., long reaction times) on a simple reaction time task, were compared on their subjective responses (i.e., ratings of liking and wanting more drug) after acute doses of d-amphetamine (0, 5, 10, and 20 mg).
Subjects who exhibited high lapses liked 20 mg d-amphetamine less than subjects who exhibited low lapses. These subjects also tended to report smaller increases in “wanting more drug” after d-amphetamine.
The findings suggest that participants who exhibit impaired attention may be less sensitive to stimulant-induced euphoria.
KeywordsInattention d-amphetamine Reward Drug liking Subjective effects Dopamine Impulsiveness
The authors thank Margo Meverden and Adam Strohm for their technical contributions.
- APA (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, D.CGoogle Scholar
- Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D et al (2000) Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 32(Suppl: i–iv):1–112Google Scholar
- de Wit H, Phan KL (2009) Positive reinforcement theories of drug use. In: Kassel JD (ed) Substance abuse and emotion. American Psychological Association, Washington, D.CGoogle Scholar
- de Wit H, Richards JB (2004) Dual determinants of drug abuse: reward and impulsivity. In: Bevins RA, Bardo MT (eds) Nebraska symposium on motivation. University of Nebraska Press, Nebraska, pp 19–55Google Scholar
- Girden ER (1992) ANOVA repeated measures, vol 84. Sage, Newbury ParkGoogle Scholar
- McNair D, Lorr M, Droppleman L (1971) Manual for the profile of mood states (manual). Educational and Industrial Service, San DiegoGoogle Scholar
- Spencer TJ, Wilens TE, Biederman J, Weisler RH, Read SC, Pratt R (2006) Efficacy and safety of mixed amphetamine salts extended release (Adderall XR) in the management of attention-deficit/hyperactivity disorder in adolescent patients: a 4-week, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 28:266–279CrossRefPubMedGoogle Scholar