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Psychopharmacology

, 208:67 | Cite as

Decreases in recollective experience following acute alcohol: a dose–response study

  • James A. BisbyEmail author
  • Julie R. Leitz
  • Celia J. A. Morgan
  • H. Valerie Curran
Original Investigation

Abstract

Rationale

Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact.

Objectives

We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alcohol and examining the way in which this affected the recollection and familiarity components of recognition memory in comparison to a placebo group.

Methods

A double-blind independent design was used, and participants received either alcohol (0.4, 0.6 or 0.8 g/kg) or a placebo drink. Participants encoded word pairs with depth of processing manipulated under generate and read conditions. Recognition memory was assessed and recollective awareness was examined through use of the remember–know procedure.

Results

Alcohol produced a dose-dependent reduction in recognition memory associated with recollection, evidenced by decreases in the number of correctly recognised items with ‘remember’ responses compared to placebo. Recognition based on a familiarity, evidenced by ‘know’ responses, showed no differences between groups or pattern of reduction compared to the placebo group. However, a negative correlation was found between recognition based on familiarity and levels of intoxication.

Conclusions

Alcohol-induced impairments in recognition memory occur in a dose-dependent manner, specifically driven by reductions in recognition associated with conscious awareness.

Keywords

Alcohol Cognition Memory 

References

  1. Abroms BD, Gottlob LR, Fillmore MT (2006) Alcohol effects on inhibitory control of attention: distinguishing between intentional and automatic mechanisms. Psychopharmacology (Berl) 188:324–334CrossRefGoogle Scholar
  2. Aggleton JP, Brown MW (1999) Episodic memory, amnesia, and the hippocampal–anterior thalamic axis. Behav Brain Sci 22:425–444PubMedGoogle Scholar
  3. Bisby JA, Brewin CR, Leitz JR, Curran HV (2009) Acute effects of alcohol on the development of intrusive memories. Psychopharmacology (Berl) 204:655–666CrossRefGoogle Scholar
  4. Bisby JA, King JA, Brewin CR, Burgess N, Curran HV (submitted) Acute effects of alcohol on intrusive memory development and viewpoint dependence in spatial memory support a dual representation model.Google Scholar
  5. Bishop KI, Curran HV (1995) Psychopharmacological analysis of implicit and explicit memory: a study with lorazepam and the benzodiazepine antagonist flumazenil. Psychopharmacology (Berl) 121:267–278CrossRefGoogle Scholar
  6. Brown MW, Aggleton JP (2001) Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci 2:51–61CrossRefPubMedGoogle Scholar
  7. Craik FIM, Lockhart RS (1972) Levels of processing: a framework for memory research. J Verbal Learn Verbal Behav 11:671–684CrossRefGoogle Scholar
  8. Curran HV, Hildebrandt M (1999) Dissociative effects of alcohol on recollective experience. Conscious Cogn 8:497–509CrossRefPubMedGoogle Scholar
  9. Curran HV, Gardiner JM, Java RI, Allen D (1993) Effects of lorazepam upon recollective experience in recognition memory. Psychopharmacology (Berl) 110:374–378CrossRefGoogle Scholar
  10. Donaldson W (1996) The role of decision processes in remembering and knowing. Mem Cognit 24:523–533PubMedGoogle Scholar
  11. Duka T, Weissenborn R, Dienes Z (2001) State-dependent effects of alcohol on recollective experience, familiarity and awareness of memories. Psychopharmacology (Berl) 153:295–306CrossRefGoogle Scholar
  12. Ewing JA (1984) Detecting alcoholism. The CAGE questionnaire. JAMA 252:1905–1907CrossRefPubMedGoogle Scholar
  13. Gardiner JM (2008) Remembering and knowing. In: Byrne JH (ed) Learning and memory: a comprehensive reference. Academic, OxfordGoogle Scholar
  14. Gardiner JM, Ramponi C, Richardson-Klavehn A (1998) Experiences of remembering, knowing, and guessing. Conscious Cognit 7:1–26CrossRefGoogle Scholar
  15. George S, Rogers R, Duka T (2005) The acute effect of alcohol on decision making in social drinkers. Psychopharmacology 182:160–169CrossRefPubMedGoogle Scholar
  16. Goodwin DW, Powell B, Bremer D, Hoine H, Stern J (1969) Alcohol and recall: state-dependent effects in man. Science 163:1358–1360CrossRefPubMedGoogle Scholar
  17. Hashtroudi S, Parker ES, DeLisi LE, Wyatt RJ, Mutter SA (1984) Intact retention in acute alcohol amnesia. J Exp Psychol Learn Mem Cognit 10:156–163CrossRefGoogle Scholar
  18. Henson RN, Rugg MD, Shallice T, Josephs O, Dolan RJ (1999) Recollection and familiarity in recognition memory: an event-related functional magnetic resonance imaging study. J Neurosci 19:3962–3972PubMedGoogle Scholar
  19. Hernandez O, Vogel-Sprott M, Huchin-Ramirez T, Ake-Estrada F (2006) Acute dose of alcohol affects cognitive components of reaction time to an omitted stimulus: differences among sensory systems. Psychopharmacology (Berl) 184:75–81CrossRefGoogle Scholar
  20. Hetem LAB, Danion JM, Diemunsch P, Brandt C (2000) Effect of a subanesthetic dose of ketamine on memory and conscious awareness in healthy volunteers. Psychopharmacology (Berl) 152:283–288CrossRefGoogle Scholar
  21. Huron C, Giersch A, Danion JM (2002) Lorazepam, sedation, and conscious recollection: a dose–response study with healthy volunteers. Int Clin Psychopharmacol 17:19–25CrossRefPubMedGoogle Scholar
  22. Jacoby LL (1991) A process dissociation framework: separating automatic from intentional uses of memory. J Lang Mem 30:513–541CrossRefGoogle Scholar
  23. Kano M, Gyoba J, Kamachi M, Mochizuki H, Hongo M, Yanai K (2003) Low doses of alcohol have a selective effect on the recognition of happy facial expressions. Hum Psychopharmacol 18:131–139CrossRefPubMedGoogle Scholar
  24. Krystal JH, Petrakis IL, Krupitsky E, Schutz C, Trevisan L, D’Souza DC (2003) NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. Ann NY Acad Sci 1003:176–184CrossRefPubMedGoogle Scholar
  25. Leitz JR, Morgan CJ, Bisby JA, Rendell PG, Curran HV (2009) Global impairment of prospective memory following acute alcohol. Psychopharmacology (Berl) 205:379–387CrossRefGoogle Scholar
  26. Lister RG, Gorenstein C, Fisher-Flowers D, Weingartner HJ, Eckardt MJ (1991) Dissociation of the acute effects of alcohol on implicit and explicit memory processes. Neuropsychologia 29:1205–1212CrossRefPubMedGoogle Scholar
  27. Mandler G (1980) Recognition: the judgment of previous occurrence. Psychol Rev 87:252–271CrossRefGoogle Scholar
  28. Manns JR, Hopkins RO, Reed JM, Kitchener EG, Squire LR (2003) Recognition memory and the human hippocampus. Neuron 37:171–180CrossRefPubMedGoogle Scholar
  29. Matthews DB, Silvers JR (2004) The use of acute ethanol administration as a tool to investigate multiple memory systems. Neurobiol Learn Mem 82:299–308CrossRefPubMedGoogle Scholar
  30. Maylor EA, Rabbitt PM, Kingstone A (1987) Effects of alcohol on word categorization and recognition memory. Br J Psychol 78:233–239PubMedGoogle Scholar
  31. Mehrabian A, Russell JA (1978) A questionnaire measure of habitual alcohol use. Psychol Rep 43:803–806PubMedGoogle Scholar
  32. Moore S, Shepherd J, Perham N, Cusens B (2007) The prevalence of alcohol intoxication in the night time economy. Alcohol Alcohol 42:629–634PubMedGoogle Scholar
  33. Parker ES, Tulving E (1983) Picture recognition on the ascending and descending limbs of the blood alcohol curve. Unpublished raw dataGoogle Scholar
  34. Parker ES, Morihisa JM, Wyatt RJ, Schwartz BL, Weingartner H, Stillman RC (1981) The alcohol facilitation effect on memory: a dose-dependent study. Psychopharmacology 74:88–92CrossRefPubMedGoogle Scholar
  35. Ray S, Bates ME (2006) Acute alcohol effects on repetition priming and word recognition memory with equivalent memory cues. Brain Cogn 60:118–127CrossRefPubMedGoogle Scholar
  36. Rugg MD, Yonelinas AP (2003) Human recognition memory: a cognitive neuroscience perspective. Trends Cogn Sci 7:313–319CrossRefPubMedGoogle Scholar
  37. Rugg MD, Fletcher PC, Allan K, Frith CD, Frackowiak RS, Dolan RJ (1998) Neural correlates of memory retrieval during recognition memory and cued recall. NeuroImage 8:262–273CrossRefPubMedGoogle Scholar
  38. Schweizer TA, Vogel-Sprott M (2008) Alcohol-impaired speed and accuracy of cognitive functions: a review of acute tolerance and recovery of cognitive performance. Exp Clin Psychopharmacol 16:240–250CrossRefPubMedGoogle Scholar
  39. Schweizer TA, Vogel-Sprott M, Danckert J, Roy EA, Skakum A, Broderick CE (2005) Neuropsychological profile of acute alcohol intoxication during ascending and descending blood alcohol concentrations. Neuropsychopharmacology 31:1301–1309Google Scholar
  40. Soderlund H, Grady CL, Easdon C, Tulving E (2007) Acute effects of alcohol on neural correlates of episodic memory encoding. NeuroImage 35:928–939CrossRefPubMedGoogle Scholar
  41. Sunram-Lea SI, Dewhurst SA, Foster JK (2008) The effect of glucose administration on the recollection and familiarity components of recognition memory. Biol Psychol 77:69–75CrossRefPubMedGoogle Scholar
  42. Townshend JM, Duka T (2002) Patterns of alcohol drinking in a population of young social drinkers: a comparison of questionnaire and diary measures. Alcohol Alcohol 37:187–192PubMedGoogle Scholar
  43. Tulving E (1983) Elements of episodic memory. Clarendon, OxfordGoogle Scholar
  44. Tulving E (1985) How many memory systems are there? Am Psychol 40:385–398CrossRefGoogle Scholar
  45. Tulving E, Schacter DL (1990) Priming and human memory systems. Science 247:301–306CrossRefPubMedGoogle Scholar
  46. Turriziani P, Serra L, Fadda L, Caltagirone C, Carlesimo GA (2008) Recollection and familiarity in hippocampal amnesia. Hippocampus 18:469–480CrossRefPubMedGoogle Scholar
  47. Weissenborn R, Duka T (2003) Acute alcohol effects on cognitive function in social drinkers: their relationship to drinking habits. Psychopharmacology 165:306–312PubMedGoogle Scholar
  48. White AM, Matthews DB, Best PJ (2000) Ethanol, memory, and hippocampal function: a review of recent findings. Hippocampus 10:88–93CrossRefPubMedGoogle Scholar
  49. Wixted JT, Squire LR (2004) Recall and recognition are equally impaired in patients with selective hippocampal damage. Cogn Affect Behav Neurosci 4:58–66CrossRefPubMedGoogle Scholar
  50. Yonelinas AP (2002) The nature of recollection and familiarity: a review of 30 years of research. J Mem Lang 46:441–517CrossRefGoogle Scholar
  51. Yonelinas AP, Jacoby LL (1995) Dissociating automatic and controlled processes in a memory-search task: beyond implicit memory. Psychol Res 57:156–165CrossRefPubMedGoogle Scholar
  52. Yonelinas AP, Kroll NE, Dobbins I, Lazzara M, Knight RT (1998) Recollection and familiarity deficits in amnesia: convergence of remember–know, process dissociation, and receiver operating characteristic data. Neuropsychol 12:323–339CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • James A. Bisby
    • 1
    Email author
  • Julie R. Leitz
    • 1
  • Celia J. A. Morgan
    • 1
  • H. Valerie Curran
    • 1
  1. 1.Clinical Psychopharmacology UnitUniversity College LondonLondonUK

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