Psychopharmacology

, 206:167

Early perturbation in feeding behaviour and energy homeostasy in olanzapine-treated rats

  • Montserrat Victoriano
  • Dominique Hermier
  • Patrick C. Even
  • Gilles Fromentin
  • Jean-François Huneau
  • Daniel Tomé
  • Renaud de Beaurepaire
Original Investigation

DOI: 10.1007/s00213-009-1593-5

Cite this article as:
Victoriano, M., Hermier, D., Even, P.C. et al. Psychopharmacology (2009) 206: 167. doi:10.1007/s00213-009-1593-5

Abstract

Rationale

The antipsychotic drug, olanzapine, often induces weight gain and glucose metabolism disturbances, which may result from feeding pattern abnormalities.

Objectives

The objectives of the study were to examine the effects of a chronic olanzapine treatment on feeding patterns in the rat and to investigate a potential time-related association between feeding patterns and the appearance of glucose metabolism abnormalities and adiposity.

Methods

Male rats were treated with olanzapine (2 mg/kg/day), haloperidol (1 mg/kg/day) or a control solution (drugs mixed with the food). In experiment 1, treatments lasted 26 days and feeding patterns were measured on day 21. In experiment 2, treatments lasted for 46 days, and an oral glucose tolerance test (OGTT) was realised on day 31. At the end of both experiments, plasma parameters and body composition were analysed.

Results

In experiment 1, olanzapine-treated animals showed increased meal number, decreased ingestion rate, meal size and inter-meal interval, and no change in total food intake. Plasma glucose, OGTT and body composition were not altered. In experiment 2, after 31 days of treatment, fasting blood glucose was increased and OGTT indicated an insulin resistance. After 46 days of treatment, hyperglycaemia was aggravated (compared to 31 days), and adiposity was increased in olanzapine-treated animals. In both experiments, the haloperidol-treated rats did not differ from the control ones.

Conclusion

Chronic olanzapine treatment produces changes in feeding patterns, in a way consistent with an increased incentive drive to eat. As a whole, the results raise the hypothesis that long-term alteration of feeding pattern by olanzapine may predispose to disturbances in the regulation of energy metabolism.

Keywords

Antipsychotic Olanzapine Metabolic syndrome Feeding pattern Rat model 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Montserrat Victoriano
    • 1
    • 2
  • Dominique Hermier
    • 1
    • 2
  • Patrick C. Even
    • 1
    • 2
  • Gilles Fromentin
    • 1
    • 2
  • Jean-François Huneau
    • 1
    • 2
  • Daniel Tomé
    • 1
    • 2
  • Renaud de Beaurepaire
    • 3
  1. 1.UMR914 Physiologie de la Nutrition et du Comportement AlimentaireINRAParisFrance
  2. 2.UMR914 Physiologie de la Nutrition et du Comportement AlimentaireAgroParisTechParisFrance
  3. 3.Laboratoire de PsychopharmacologieCentre Hospitalier Paul-GuiraudVillejuifFrance

Personalised recommendations