, Volume 206, Issue 1, pp 121–132 | Cite as

Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia

  • Henrik WalterEmail author
  • Hannes Kammerer
  • Karel Frasch
  • Manfred Spitzer
  • Birgit Abler
Original Investigation



To study the mesolimbic dopamine system during expectation and receipt or omission of rewards in partially remitted patients with schizophrenia treated with the atypical antipsychotic olanzapine.


We studied 16 patients with a current episode of schizophrenia, all treated with the atypical drug olanzapine, and 16 healthy subjects using functional magnetic resonance imaging. Subjects performed a delayed incentive paradigm with monetary rewards.


During reward expectation, both, patients with schizophrenia and healthy control subjects, showed activation of the ventral striatum and midbrain in the vicinity of the ventral tegmental area. Significant categorical group differences emerged in the anterior cingulate cortex with only healthy controls showing increasing activation with increasing reward. In the patients, activation of this region was inversely correlated with positive symptoms. During outcome, both, patients with schizophrenia and healthy controls, showed activation of the ventral striatum and the mesial prefrontal cortex. Significant categorical group differences emerged in the right ventrolateral prefrontal cortex for the salience contrast with healthy controls showing a U-shaped activation curve, i.e., higher activation for either omission or receipt of reward compared to no reward.


Our findings partially support the current concept of dopaminergic dysfunction in schizophrenia, suggesting a rather hyperactive mesolimbic dopamine system and reduced prefrontal activation, at least in partially remitted patients treated with atypical antipsychotics.


fMRI Schizophrenia Reward Dopamine Positive and negative symptoms 



Thanks to Christian Wolf for the thorough expert review of the final draft of the paper.

The experiments comply with the current laws of the country in which they were performed.

Acknowledgement of funding

The study was supported in part by a personal grant to Birgit Abler from the DAAD (German Academic Exchange Service).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Henrik Walter
    • 1
    Email author
  • Hannes Kammerer
    • 2
  • Karel Frasch
    • 3
  • Manfred Spitzer
    • 2
  • Birgit Abler
    • 2
  1. 1.Department of Psychiatry, Division of Medical PsychologyRheinische Friedrich-Wilhelms-University BonnBonnGermany
  2. 2.Department of Psychiatry IIIUniversity of UlmUlmGermany
  3. 3.Department of Psychiatry IIUniversity of UlmGünzburgGermany

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