Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents
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Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity. The present study sought to clarify and extend upon these behavioural findings by investigating the influence of glucose administration on event-related potential (ERP) components that are thought to be differentially mediated by recollection and familiarity processes in healthy adolescents.
In a within-subjects design, participants performed a recognition memory task, during which time electroencephalogram (EEG) was recorded, subsequent to ingestion of either (a) glucose or (b) placebo in a counterbalanced order.
Response times during the recognition memory task were observed to be faster for the glucose condition, relative to a placebo control. Further, glucose ingestion was associated with an enhanced left parietal old/new ERP effect (a marker of recollection) and an enhanced mid-frontal old/new ERP effect (known to be mediated by familiarity).
These findings (a) support the results of previous research that the ‘glucose memory facilitation effect’ can be extended to healthy adolescents, but (b) suggest that glucose enhances both the recollection and familiarity components of recognition memory. The observed ERP profile has important implications for the proposal that glucose specifically targets the hippocampus in modulating cognitive performance.
KeywordsRecognition memory Glucose Event-related potentials Adolescents
Michael Smith was the recipient of an Experimental Psychology Society Study Visit Grant and a University of Western Australia Convocation Travel Award at the time that the data reported here were collected.
- Brown LA, Riby LM (2007) Event-related potential (ERP) investigations of hippocampal and frontal lobe function in younger and older adults: Which neuro-cognitive mechanisms mediate the glucose facilitation effect? Paper presented at the British Association for Psychopharmacology Summer Meeting, Harrogate, North YorkshireGoogle Scholar
- Craft S, Murphy C, Wemstrom J (1994) Glucose effects on complex memory and nonmemory tasks: the influence of age, sex, and glucoregulatory response. Psychobiology 22:95–105Google Scholar
- de Bruin EA, Gilsenan MB (2009) Effects of food energy on cognitive performance: no support from event-related potentials (yet?). Br J Nutr (in press)Google Scholar
- Gardiner JM, Richardson-Klavehn A (2000) Remembering and knowing. In: Tulving E, Craik FIM (eds) The Oxford Handbook of Memory. Oxford University Press, New York, pp 229–244Google Scholar
- Jasper HH (1958) Ten-twenty electrode system of the international federation. Electroencephalogr Clin Neurophysiol 10:371–373Google Scholar
- Kučera H, Francis WN (1967) Computational analysis of present-day American English. Brown University Press, ProvidenceGoogle Scholar
- Pettersen JA, Skelton RW (2000) Glucose enhances long-term declarative memory in mildly head-injured varsity rugby players. Psychobiology 28:81–89Google Scholar
- Riby LM, Riby DM (2006) Glucose, ageing and cognition: The hippocampus hypothesis. In: Ballesteros S (ed) Age, Cognition and Neuroscience/Envejecimiento. Cognición y Neurociencia, UNED, Varia MadridGoogle Scholar
- Riby LM, Marriott A, Bullock R, Hancock J, Smallwood J, McLaughlin J (2009) The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment. Eur J Clin Nutr (in press)Google Scholar
- Stenberg G, Hellman J, Johansson M, Rosén I (2009) Familiarity or conceptual priming: event-related potentials in name recognition. J Cogn Neurosci (in press)Google Scholar
- Winocur G (1995) Glucose-enhanced performance by aged rats on a test of conditional discrimination learning. Psychobiology 23:270–276Google Scholar