Psychopharmacology

, Volume 204, Issue 3, pp 431–443 | Cite as

Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals

  • Chris Pickering
  • Johan Alsiö
  • Anna-Lena Hulting
  • Helgi B. Schiöth
Original Investigation

Abstract

Introduction

Vulnerability for weight gain is an individual trait. Obese people undertake dieting, but permanent weight loss is difficult to attain due to repeated phases of relapse to excess consumption.

Materials and methods

In this study, male Wistar rats were trained to operantly self-administer pellets followed by free-choice access in the homecage to high-fat high-sugar (HFHS) diet consisting of 30% sucrose, lard, standard rodent chow and water. Animals were divided into obesity-prone (OP) and obesity-resistant (OR) groups based on relative weight gain compared to normally fed controls despite equal consumption of HFHS.

Results and discussion

After 4 weeks of HFHS access, OP and OR animals did not differ in motivation for food pellets in terms of progressive ratio break point, lever pressing or response rate. However, upon discontinuation of the HFHS diet, differences between the OP and OR groups were noted. OP animals increased their motivation (i.e. craving) during the second withdrawal week and reduced time spent in the centre of an open field (increased anxiety) compared to the OR animals. Both OP and OR animals consumed less of the standard rodent chow during the first week of withdrawal when compared to normally fed controls. But, while the OR animals quickly returned to control levels of food consumption, OP animals continued to consume less standard rodent chow.

Conclusion

The results show for the first time that withdrawal from free-choice HFHS induces craving that is specific to the OP animals and suggests that OP individuals may have withdrawal symptoms that are similar to those induced by addictive drugs.

Keywords

Diet-induced obesity Operant self-administration Progressive ratio Fixed ratio Whole-animal physiology 

Notes

Acknowledgements

We thank Dr Jonas Lindblom for valuable discussions. The studies were supported by the Swedish Research Council, AFA insurance, Alcohol Research Council of the Swedish Alcohol Retailing Monopoly, Åhlen Foundation and The Novo Nordisk Foundation. CP was supported by the Swedish Brain Foundation (Hjärnfonden).

Supplementary material

213_2009_1474_MOESM1_ESM.doc (16 kb)
Supplementary Table 1(DOC 20.8 KB)

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Chris Pickering
    • 1
  • Johan Alsiö
    • 1
  • Anna-Lena Hulting
    • 2
  • Helgi B. Schiöth
    • 1
  1. 1.Department of Neuroscience Functional PharmacologyUppsala UniversityUppsalaSweden
  2. 2.Department of Endocrinology, Metabolism and DiabetologyKarolinska Institutet/Karolinska University Hospital-SolnaStockholmSweden

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