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Psychopharmacology

, Volume 204, Issue 3, pp 391–402 | Cite as

Synergistic interaction between nicotine and social rewards in adolescent male rats

  • Kenneth J. Thiel
  • Federico Sanabria
  • Janet L. Neisewander
Original Investigation

Abstract

Rationale

Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced.

Objectives

We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produce an enhanced conditioned place preference (CPP) relative to either reward given alone. The present study further examined the nature of drug–social reward interactions using nicotine.

Methods

Dose–effect functions for nicotine-CPP were established using two different routes of administration (vehicle, 0.1, 0.3, and 0.6 mg/kg, SC and vehicle, 0.01, 0.03, and 0.06 mg/kg, IV). The effects of nicotine on social reward-CPP and social play behavior were next examined using parameters presumed to be sub-threshold for establishing social reward- and nicotine-CPP.

Results

Dose-dependent nicotine-CPP was observed using both routes of administration. Two pairings of the initially non-preferred side of the apparatus with either SC nicotine or another adolescent rat failed to produce CPP when examined alone, but together produced a robust CPP despite nicotine reducing social play. This interaction effect was not observed with the IV nicotine. A final experiment demonstrated that the enhancement of CPP with the combination of rewards was not due to additive effects of weak, sub-threshold conditioning.

Conclusions

These findings suggest that nicotine and social rewards interact synergistically in adolescent rats resulting in a greater, perhaps qualitatively different, reward than either reward given alone. Understanding drug–social reward interactions may provide new directions for development of preventions and interventions of adolescent smoking.

Keywords

Adolescence Conditioned place preference Place conditioning Drug conditioning Intravenous nicotine 

Abbreviations

CS

Conditioned stimulus

US

Unconditioned stimulus

IV

Intravenous

SC

Subcutaneous

IP

Intraperitoneal

CPP

Conditioned place preference

Veh

Vehicle

N

Nicotine

Soc

Social playmate

Iso

Isolated

Notes

Acknowledgements

The project described was supported by grants DA011064, R21DA023123 and F31DA02746 from the National Institute on Drug Abuse. The authors wish to thank Jenny Browning, Valeria Routt, Sarah Thiel, Michael Painter, Suzanne Weber, and Erin Dickey for their contributions during data collection. The authors also wish to thank Glenn Guerin for advice with catheter construction.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Kenneth J. Thiel
    • 1
  • Federico Sanabria
    • 1
  • Janet L. Neisewander
    • 1
  1. 1.Department of PsychologyArizona State UniversityTempeUSA

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