Psychopharmacology

, Volume 204, Issue 2, pp 287–297

Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (±)-3,4-methylenedioxymethamphetamine (ecstasy) in rats

  • Matthew R. Skelton
  • Tori L. Schaefer
  • Nicole R. Herring
  • Curtis E. Grace
  • Charles V. Vorhees
  • Michael T. Williams
Original Investigation

Abstract

Rationale

We have previously shown that (±)-3,4-methylenedioxymethamphetamine (MDMA) treatment from postnatal days (P)11 to P20 leads to learning and memory deficits when the animals are tested as adults. Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity.

Objective

Due to the similarities between MDMA and 5-MeO-DIPT and the substitution of 5-MeO-DIPT for MDMA, the purpose of this study was to compare the developmental effects of these drugs.

Methods

Within a litter, animals were treated from P11 to P20 with either MDMA, 5-MeO-DIPT, or saline.

Results

MDMA-treated animals showed increased anxiety in a measure of defensive marble burying, as well as deficits in spatial and path integration learning. 5-MeO-DIPT-treated animals showed spatial learning deficits; however, there were no deficits observed in spatial memory or path integration learning. 5-MeO-DIPT-treated animals also showed hyperactivity in response to a challenge dose of methamphetamine.

Conclusions

The results show that treatment with either 5-MeO-DIPT or MDMA during development results in cognitive deficits and other behavioral changes but the pattern of effects is distinct for each drug.

Keywords

Drug abuse Anxiety Behavior Learning Locomotor activity Memory Psychostimulant 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Matthew R. Skelton
    • 1
  • Tori L. Schaefer
    • 1
  • Nicole R. Herring
    • 1
  • Curtis E. Grace
    • 1
  • Charles V. Vorhees
    • 1
    • 2
  • Michael T. Williams
    • 1
    • 2
  1. 1.Division of NeurologyCincinnati Children’s Research Foundation and University of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Division of Neurology, MLC 7044Cincinnati Children’s Research FoundationCincinnatiUSA

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