, Volume 204, Issue 2, pp 375–378 | Cite as

MDMA: On the translation from rodent to human dosing

  • A. Richard GreenEmail author
  • Johan Gabrielsson
  • Charles A. Marsden
  • Kevin C. F. Fone

The recent paper in this journal by Goni-Allo et al. (2008) was a welcome addition to the literature on the effects of MDMA in rodents because it examined functional changes and related them to the systemic exposure (e.g., plasma concentrations) of the drug. Such pharmacodynamic–pharmacokinetic (or quantitative pharmacology) studies are vital if we are to attempt to relate preclinical findings to the possible acute and long-term consequences of human ingestion of MDMA. The debate on whether preclinical findings on the serotonergic neurotoxicity induced by MDMA in the rodent brain can be extrapolated to human recreational usage has engaged scientists’ minds for around 20 years. Concerns have been raised as to whether the administered dose of MDMA typically used to cause neurotoxicity in rats allows any translational projections to be made as to the doses required to produce similar damage in the brains of humans following recreational use of the drug. These concerns are discussed in...


Methamphetamine Peak Plasma Concentration Plasma Protein Binding Neurotoxicity MDMA 
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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • A. Richard Green
    • 1
    Email author
  • Johan Gabrielsson
    • 2
  • Charles A. Marsden
    • 1
  • Kevin C. F. Fone
    • 1
  1. 1.Institute of Neuroscience, School of Biomedical Sciences, Queen’s Medical CenterUniversity of NottinghamNottinghamUK
  2. 2.Discovery DMPK and BACAstraZeneca R and D MölndalMölndalSweden

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