Psychopharmacology

, Volume 204, Issue 1, pp 25–35

24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum

  • F. Joseph McClernon
  • Rachel V. Kozink
  • Avery M. Lutz
  • Jed E. Rose
Original Investigation

Abstract

Rationale

Exposure to smoking-related cues can trigger relapse in smokers attempting to maintain abstinence.

Objectives

In the present study, we evaluated the effect of 24-h smoking abstinence on brain responses to smoking-related cues using functional magnetic resonance imaging (fMRI).

Materials and methods

Eighteen adult smokers underwent fMRI scanning following smoking as usual (satiated condition) and following 24-h abstinence (abstinent condition). During scanning, they viewed blocks of photographic smoking and control cues.

Results

Following abstinence, greater activation was found in response to smoking cues compared to control cues in parietal (BA 7/31), frontal (BA 8/9), occipital (BA 19), and central (BA 4) cortical regions and in dorsal striatum (putamen) and thalamus. In contrast, no smoking cue greater than control cue activations were observed following smoking as usual. Direct comparisons between conditions (satiated vs. abstinent) showed greater brain reactivity in response to smoking cues following abstinence. In addition, positive correlations between pre-scan craving in the abstinent condition and smoking cue activation were observed in right dorsomedial prefrontal cortex (dmPFC) including superior frontal gyrus (BA 6/10), anterior cingulate gyrus (BA 32), and supplementary motor area (BA 6).

Conclusions

The present findings indicate that smoking abstinence significantly potentiates neural responses to smoking-related cues in brain regions subserving visual sensory processing, attention, and action planning. Moreover, greater abstinence-induced craving was significantly correlated with increased smoking cue activation in dmPFC areas involved in action planning and decision making. These findings suggest that drug abstinence can increase the salience of conditioned cues, which is consistent with incentive-motivation models of addiction.

Keywords

Cue-reactivity Craving Nicotine dependence fMRI Smoking Dorsal striatum 

Supplementary material

213_2008_1436_MOESM1_ESM.doc (24 kb)
Table S1Brain areas of significant activation for smoking cues versus control cues as measured by BOLD-fMRI across conditions (DOC 23.5 KB)
213_2008_1436_MOESM2_ESM.ppt (1.9 mb)
Figure S1BOLD response to smoking cues was greater than response to control cues across smoking conditions in right paracentral lobule (PcL; BA 5), right cuneus (Cun; BA 19), hypothalamus (Hyp), left middle occipital gyrus (MOG; BA 19), right superior frontal gyrus (SFG; BA 6), and left insula (Ins). There were no significant areas of activation for control cues > smoking cues (PPT 1.89 MB)

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • F. Joseph McClernon
    • 1
    • 2
  • Rachel V. Kozink
    • 1
  • Avery M. Lutz
    • 1
  • Jed E. Rose
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA
  2. 2.Duke University Medical CenterDurhamUSA

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