24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum
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Exposure to smoking-related cues can trigger relapse in smokers attempting to maintain abstinence.
In the present study, we evaluated the effect of 24-h smoking abstinence on brain responses to smoking-related cues using functional magnetic resonance imaging (fMRI).
Materials and methods
Eighteen adult smokers underwent fMRI scanning following smoking as usual (satiated condition) and following 24-h abstinence (abstinent condition). During scanning, they viewed blocks of photographic smoking and control cues.
Following abstinence, greater activation was found in response to smoking cues compared to control cues in parietal (BA 7/31), frontal (BA 8/9), occipital (BA 19), and central (BA 4) cortical regions and in dorsal striatum (putamen) and thalamus. In contrast, no smoking cue greater than control cue activations were observed following smoking as usual. Direct comparisons between conditions (satiated vs. abstinent) showed greater brain reactivity in response to smoking cues following abstinence. In addition, positive correlations between pre-scan craving in the abstinent condition and smoking cue activation were observed in right dorsomedial prefrontal cortex (dmPFC) including superior frontal gyrus (BA 6/10), anterior cingulate gyrus (BA 32), and supplementary motor area (BA 6).
The present findings indicate that smoking abstinence significantly potentiates neural responses to smoking-related cues in brain regions subserving visual sensory processing, attention, and action planning. Moreover, greater abstinence-induced craving was significantly correlated with increased smoking cue activation in dmPFC areas involved in action planning and decision making. These findings suggest that drug abstinence can increase the salience of conditioned cues, which is consistent with incentive-motivation models of addiction.
KeywordsCue-reactivity Craving Nicotine dependence fMRI Smoking Dorsal striatum
This research was supported by NIDA grant K23DA017261 to Dr. McClernon and by an unrestricted research grant from Philip Morris USA, Inc to Dr. Rose. We thank Natalie Goutkin for her assistance with MRI scanning.
- CDC (2002) Cigarette smoking among adults—United States, 2000. Morb Mortal 51:642–645Google Scholar
- David SP, Munafo MR, Johansen-Berg H, Mackillop J, Sweet LH, Cohen RA, Niaura R, Rogers RD, Matthews PM, Walton RT (2007) Effects of acute nicotine abstinence on cue-elicited ventral striatum/nucleus accumbens activation in female cigarette smokers: a functional magnetic resonance imaging study. Brain Imaging Behav 1:43–57PubMedCrossRefGoogle Scholar
- Gilbert DG, Rabinovich NE (1999) International Smoking Image Series, Version 1.2, 1.2 edn. Intergrative Neuroscience Laboratory, Southern Illinois University-Carbondale, Intergrative Neuroscience Laboratory, Southern Illinois University—CarbondaleGoogle Scholar
- Lang PJ, Bradley MM, Cuthbert BN (1995) International Affective Picture System (IAPS): Technical Manual and Affective Ratings. NIMH Center for the Study of Emotion and Attention, University of FL, Gainesville, FL., NIMH Center for the Study of Emotion and Attention, University of FL, Gainesville, FLGoogle Scholar
- Lawrence AD, Sahakian BJ, Robbins TW (1998) Cognitive functions and corticostriatal circuits: Insights from Huntington’s disease. Trends Cogn Sci 2Google Scholar