Initial nicotine sensitivity in humans as a function of impulsivity
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Impulsivity is related to greater risk of nicotine dependence, perhaps by enhancing sensitivity to nicotine’s reinforcing and rewarding effects during initial smoking experiences.
We examined the influence of impulsivity characteristics on acute sensitivity to nicotine reward, reinforcement, and other effects in 131 young adult nonsmokers.
Materials and methods
Participants engaged in four sessions: the first three to assess dose–response effects of nasal spray nicotine (0, 5, 10 μg/kg) on reward, as well as mood, physiological, and performance effects, and the fourth to assess nicotine reinforcement using a choice procedure. Five impulsivity factors, derived from factor analysis of self-report (e.g., Barratt Impulsivity Scale, Sensation-Seeking Scale, Novelty seeking) and computer (stop–go, delay discounting, probability discounting) measures of impulsivity, were labeled “novelty seeking”, “response disinhibition”, “extraversion”, “inhibition”, and “probability/delay discounting”.
The associations of novelty seeking with nicotine reinforcement and reward tended to move in opposite directions by sex, generally being directly related in men but inversely or unrelated in women. Similarly, response disinhibition was associated with reward and some mood responses to nicotine that differed by sex. Extraversion was inversely associated with nicotine reinforcement. Characteristics loading on to the other impulsivity factors had little association with nicotine sensitivity.
These results are preliminary, but they suggest that characteristics broadly related to impulsivity, especially novelty seeking and response disinhibition, are associated with initial sensitivity to some effects of acute nicotine, including reinforcement and reward, and may do so differentially between men and women.
KeywordsNicotine Sensitivity Impulsivity Sex differences Nonsmokers Reinforcement Reward
- Audrain-McGovern J, Nigg J, Perkins KA (2008) Endophenotypes for nicotine dependence risk at or before initial nicotine exposure. National Cancer Institute Monograph 22, phenotypes and endophenotypes: foundations for genetic studies of nicotine use and dependence (chapter 7). NCI, Washington DC (in press)Google Scholar
- Cloninger CR, Pryzbeck TR, Svrakic DM, Wetzel RD (1994) The Temperament and Character Inventory (TCI): a guide to its development and use. Center for Psychobiology of Personality, Washington University, St. LouisGoogle Scholar
- deWit H, Richards JB (2004) Dual determinants of drug use in humans: reward and impulsivity. In: Bevins RA, Bardo MT (eds) Motivational factors in the etiology of drug abuse. University of Nebraska Press, Lincoln, pp 19–55Google Scholar
- Eysenck HJ, Eysenck BG (1968) Eysenck Personality Inventory. Educational and Industrial Testing Services, San DiegoGoogle Scholar
- Howard MO, Kivlahan D, Walker RD (1997) Cloninger’s tridimensional theory of personality and psychopathology: applications to substance use disorders. J Stud Alc 58:48–66Google Scholar
- Mackintosh NJ (1974) The psychology of animal learning. Academic, New YorkGoogle Scholar
- Marks MJ, Campbell SM, Romm E, Collins AC (1991) Genotype influences the development of tolerance to nicotine in the mouse. J Pharmacol Exper Ther 259:392–402Google Scholar
- McNair DM, Loor M, Droppelman LF (1971) Profile of Mood States. Educational and Testing Service, San DiegoGoogle Scholar
- Perkins KA (2008) Sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking. In: Bevins R, Caggiula AR (eds) The motivational impact of nicotine and its role in tobacco use. Springer, New YorkGoogle Scholar
- Perkins KA, Epstein LH, Stiller R, Jennings JR, Christiansen C, McCarthy T (1986) An aerosol spray alternative to cigarette smoking in the study of the behavioral and physiological effects of nicotine. Behav Res Meth Instr Comput 18:420–426Google Scholar
- Perkins KA, Grobe JE, Fonte C, Goettler J, Caggiula AR, Reynolds WA, Stiller RL, Scierka A, Jacob RG (1994a) Chronic and acute tolerance to subjective, behavioral, and cardiovascular effects of nicotine in humans. J Pharmacol Exper Ther 270:628–638Google Scholar
- Perkins KA, Gerlach D, Broge M, Grobe JE, Sanders M, Fonte C, Vender J, Cherry C, Wilson A (2001a) Dissociation of nicotine tolerance from tobacco dependence in humans. J Pharmacol Exper Ther 296:849–856Google Scholar
- Zuckerman M (1994) Behavioral expressions and biosocial bases of sensation seeking. Cambridge Univ Press, Cambridge, UKGoogle Scholar