The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats
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Overall drug acceptability is thought to be a function of the balance between its rewarding and aversive effects, the latter of which is reportedly affected by polydrug use.
Given that nicotine and alcohol are commonly co-used, the present experiments sought to assess nicotine’s impact on ethanol’s aversive effects within a conditioned taste aversion design.
Materials and methods
Experiment 1 examined various doses of nicotine (0, 0.4, 0.8, 1.2 mg/kg) to determine a behaviorally active dose, and experiment 2 examined various doses of ethanol (0, 0.5, 1.0, 1.5 g/kg) to determine a dose that produced intermediate aversions. Experiment 3 then examined the aversive effects of nicotine (0.8 mg/kg) and ethanol (1.0 g/kg) alone and in combination. Additionally, nicotine’s effects on blood alcohol concentrations (BAC) and ethanol-induced hypothermia were examined.
Nicotine and ethanol combined produced aversions significantly greater than those produced by either drug alone or the summed aversive effects of the individual compounds. These effects were unrelated to changes in BAC, but nicotine and ethanol combined produced a prolonged hypothermic effect which may contribute to the increased aversions induced by the combination.
These data demonstrate that nicotine may interact with ethanol, increasing ethanol’s aversive effects. Although the rewarding effects of concurrently administered nicotine and ethanol were not assessed, these data do indicate that the reported high incidence of nicotine and ethanol co-use is unlikely due to reductions in the aversiveness of ethanol with concurrently administered nicotine. It is more likely attributable to nicotine-related changes in ethanol’s rewarding effects.
KeywordsNicotine Ethanol Drug interactions Polydrug use Drug acceptability Conditioned taste aversion Hypothermia Blood alcohol Rats Female
- Elkins RL, Orr TE, Edwards GL, Storming TA, Fei Y, Carl GF, Hobbs SH, Buccafusco JJ, Rausch JL (2003) Cocaine-induced expression differences of 5-HT3 receptors and Na+/K+-APTase pump subunits in amygdalae of taste-aversion-prone and taste-aversion-resistant rats. Ann N Y Acad Sci 985:519–521CrossRefGoogle Scholar
- Escarabajal MD, De Witte P, Quertemont E (2003) Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats. Psychopharmacology (Berl) 167:130–136Google Scholar
- Freeman KB, Riley AL (2008) The origins of conditioned taste aversion learning: an historical analysis. In: Reilly S, Schachtman TD (eds) Conditioned taste aversion: behavioral and neural processes. Oxford University Press, New York, NY (in press) Google Scholar
- Leonard B (1997) Fundamentals of psychopharmacology, 2nd edn. Wiley, New YorkGoogle Scholar
- National Institute on Alcohol Abuse and Alcoholism (1998) Alcohol Alert No. 39: Alcohol and Tobacco. Available from: http://pubs.niaaa.nih.gov/publications/aa39.htm. Accessed October, 2006
- Revusky S, Garcia J (1970) Learned associations over long delays. In: Bower G, Spence J (eds) Psychology of learning and motivation: advances in research and theory. Academic, New York, pp 1–84Google Scholar
- Riley AL, Freeman KB (2004) Conditioned flavor aversions: assessment of drug-induced suppression of food intake. In: Crawley JN, Gerfen C, McKay R, Rogawski M, Sibley DR, Skolnick P (eds) Current protocols in neuroscience. Wiley, New York, pp 8.6E.1–8.6E.12Google Scholar
- Riley AL, Davis CM, Roma PG (2008) Strain differences in taste aversion learning: Implications for animal models of drug abuse. In: Reilly S, Schachtman TR (eds) Conditioned taste aversion: behavioral and neural processes. Oxford University Press, New York (in press)Google Scholar