Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys
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3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is frequently used in hot environments, such as rave parties. Studies in laboratory animals have shown that ambient temperature can alter the behavioral and neurochemical effects of MDMA.
To examine the influence of ambient temperature on the relative reinforcing strength of MDMA and reinstatement of behavior previously maintained by MDMA is the objective of the study.
The effects of cool (18°C), room (24°C), and warm (31°C) temperatures were examined when MDMA was available under a concurrent fixed-ratio 30 schedule of MDMA (saline, 0.03–0.3 mg/kg/injection) and food choice in rhesus monkeys (n = 5). During saline substitutions, the effect of noncontingent MDMA (0.03–0.3 mg/kg) on response allocation was examined at each ambient temperature.
At room temperature, MDMA choice increased as a function of dose, such that food was preferred over a low MDMA dose (0.03 mg/kg/injection), whereas higher doses were preferred over food. Elevating the ambient temperature significantly increased the relative reinforcing strength of 0.03 mg/kg/injection MDMA, and lowering the ambient temperature significantly attenuated the choice of 0.1 mg/kg/injection MDMA. Noncontingent injections of MDMA administered before a session in which saline was the alternative to food dose-dependently increased injection-lever responding; this effect was not influenced by ambient temperature.
These results suggest that ambient temperature can affect the relative reinforcing strength of MDMA, but not MDMA-induced reinstatement. Furthermore, these results suggest environmental strategies for decreasing the reinforcing strength of MDMA.
KeywordsAmbient Temperature Drug Choice MDMA Reinstatement Rhesus monkey Self-Administration
We appreciate the insightful comments and statistical assistance of Linda Porrino and Beth Reboussin. This research was supported by the National Institute on Drug Abuse grants DA-06634 (MAN) and DA-020281 (MLB).
- Banks ML, Sprague JE, Kisor DF, Czoty PW, Nichols DE, Nader MA (2007b) Ambient temperature effects on 3,4-methylenedioxymethamphetamine (MDMA)-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metab Disp 35(10) (in press). http://dx.doi.org/10.1124/dmd.107.016261
- Cador M, Isingrini E, Keiflin R (2006) Systemic cocaine can reinstate an instrumental response not directed towards cocaine but previously performed under cocaine. Soc Neurosci Abstract 189.12Google Scholar
- Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE (2006). Monitoring the future national survey results on drug use, 1975–2005: Volume II, College students and adults ages 19–45 (NIH Publication No. 06-5884). National Institute on Drug Abuse, Bethesda, MDGoogle Scholar
- Woolverton WL, Nader MA (1990) Experimental evaluation of the reinforcing effects of drugs, in Modern Methods in Pharmacology. Volume 6: Testing and Evaluation of Drugs of Abuse (Adler MW and Cowan A eds) pp 165–192, Wiles-Liss, Inc., New York, NYGoogle Scholar