Psychopharmacology

, Volume 194, Issue 4, pp 545–554

Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing

  • Marika Paaver
  • Niklas Nordquist
  • Jüri Parik
  • Maarike Harro
  • Lars Oreland
  • Jaanus Harro
Original Investigation

DOI: 10.1007/s00213-007-0867-z

Cite this article as:
Paaver, M., Nordquist, N., Parik, J. et al. Psychopharmacology (2007) 194: 545. doi:10.1007/s00213-007-0867-z

Abstract

Rationale

Low capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic functioning.

Objectives

The effect of the two markers for serotonin system efficiency on performance in a visual comparison task (VCT) and self-reported impulsiveness (Barratt Impulsiveness Scale, BIS-11) were investigated in healthy adolescents participating in the Estonian Children Personality Behaviour and Health Study. Possible confounding effect of general cognitive abilities on the performance in VCT was controlled for.

Results

Low platelet MAO activity and carrying of the S allele of 5-HTTLPR were both associated with higher error-rate and more impulsive performance in VCT. Platelet MAO activity and 5-HTTLPR S allele had a significant interactive effect on self-reported impulsivity (BIS-11). The effect of platelet MAO activity on both self-reported and performance impulsivity was significant only in the S allele carriers. The effect of 5-HTTLPR S allele on impulsive performance remained significant after controlling for general cognitive abilities.

Conclusions

The two markers of lower serotonergic capacity, 5-HTTLPR S allele and low platelet MAO activity, have a similar and partly synergistic influence on self-reported as well as performance measures of impulsivity.

Keywords

Impulsiveness Cognitive abilities Platelet monoamine oxidase Serotonin Speed and accuracy of information processing 5-HT transporter gene 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Marika Paaver
    • 1
  • Niklas Nordquist
    • 2
  • Jüri Parik
    • 3
  • Maarike Harro
    • 4
  • Lars Oreland
    • 2
  • Jaanus Harro
    • 1
  1. 1.Department of PsychologyUniversity of TartuTartuEstonia
  2. 2.Department of Neuroscience, PharmacologyUniversity of UppsalaUppsalaSweden
  3. 3.Institute of Molecular and Cell BiologyUniversity of TartuTartuEstonia
  4. 4.National Institute for Health DevelopmentEstonian Centre of Behavioural and Health SciencesTallinnEstonia

Personalised recommendations