Psychopharmacology

, Volume 193, Issue 2, pp 215–223 | Cite as

Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats

  • Jean-Charles Bizot
  • Nicolas Chenault
  • Bérengère Houzé
  • Alexandre Herpin
  • Sabrina David
  • Stéphanie Pothion
  • Fabrice Trovero
Original Investigation

Abstract

Rationale

Impulsivity is a core symptom of attention deficit/hyperactivity disorder (ADHD). The spontaneously hypertensive rats (SHR) is a strain commonly used as an animal model of ADHD. However, there is no clear evidence that psychostimulants, which are used for treatment of ADHD, reduce impulsivity in SHR. Because ADHD mainly affects children, it may be relevant to study psychostimulants on juvenile animals.

Objectives

Using tolerance to delay of reward as index of impulsivity, the effects of methylphenidate were assessed in adult SHR, Wistar Kyoto (WKY) and Wistar rats and in juvenile Wistar rats.

Materials and methods

Animals were trained in a T-maze to choose between a small-but-immediate and a large-but-delayed reward. Adult SHR, WKY and Wistar rats were compared for their ability to tolerate a 15-s delay. The effect of methylphenidate on the tolerance to a 30-s delay was studied in adult rats of the three strains and in juvenile (4.5 to 6.5-week-old) Wistar rats.

Results

In adult rats, the waiting ability was lower in SHR than in control strains. Waiting ability was improved by methylphenidate (3 and 5 mg/kg) in juveniles, but not by methylphenidate (3 mg/kg) in adults.

Conclusions

These data support the idea that SHR are more impulsive than control strains. However, at the dose studied, methylphenidate fails to improve tolerance to delay in adult rats whatever the strain used. The reduction of impulsivity induced by methylphenidate in juvenile Wistar rats indicates that juvenile animals may be suitable for testing the therapeutic potential of drugs intended to the treatment of ADHD in children.

Keywords

Methylphenidate Juvenile Rats Impulsivity ADHD Waiting ability Wistar SHR WKY T-maze Psychostimulant 

Notes

Acknowledgements

We thank Dr. Marie-Hélène Thiébot for her invaluable advice in the preparation of the manuscript.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Jean-Charles Bizot
    • 1
  • Nicolas Chenault
    • 1
  • Bérengère Houzé
    • 1
  • Alexandre Herpin
    • 1
  • Sabrina David
    • 1
  • Stéphanie Pothion
    • 1
  • Fabrice Trovero
    • 1
  1. 1.Key-Obs SAParc Technologique de La SourceOrleansFrance

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