Psychopharmacology

, Volume 192, Issue 2, pp 291–298 | Cite as

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

  • Xavier Noël
  • Martial Van der Linden
  • Mathieu d’Acremont
  • Antoine Bechara
  • Bernard Dan
  • Catherine Hanak
  • Paul Verbanck
Original Investigation

Abstract

Background

Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information.

Methods

Forty recently detoxified individuals with alcoholism were compared with 40 healthy non-substance abusers on the “Alcohol-Shifting Task”, a variant of the go/no-go paradigm requiring a motor response to targets and no response to distracters. The aim was to test the ability of alcoholics to discriminate between alcohol-related and neutral words. Sometimes, the alcohol-related words were the targets for the “go” response, with neutral words as distracters, sometimes the reverse. Several shifts in target type occurred during the task.

Results

Alcoholics made significantly more commission errors (i.e., press a key when a distracter displayed) and more omission errors (i.e., not press a key when a target displayed) than controls. Moreover, the number of commission errors was greater in alcoholics when alcohol-related stimuli had to be detected.

Conclusions

These results demonstrate that alcoholics exhibit a basic prepotent response inhibition deficit, which is enhanced when the response to be suppressed is related to alcohol. We discuss clinical and theoretical implications of these findings.

Keywords

Alcoholism Response inhibition Attentional bias 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Xavier Noël
    • 1
  • Martial Van der Linden
    • 2
  • Mathieu d’Acremont
    • 3
  • Antoine Bechara
    • 4
    • 5
  • Bernard Dan
    • 6
  • Catherine Hanak
    • 1
  • Paul Verbanck
    • 1
  1. 1.Clinic of Addictions, C.H.U BrugmannFree University of Brussels (ULB)BrusselsBelgium
  2. 2.Cognitive Psychopathology and Neuropsychology UnitUniversity of GenevaGenevaSwitzerland
  3. 3.Child and Adolescent Psychology UnitUniversity of GenevaGenevaSwitzerland
  4. 4.Department of NeurologyUniversity of IowaIowa CityUSA
  5. 5.Department of PsychologyUniversity of Southern CaliforniaLos AngelesUSA
  6. 6.Department of Neurology, Hôpital Universitaire des Enfants Reine FabiolaFree University of Brussels (ULB)BrusselsBelgium

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