Opioids for hedonic experience and dopamine to get ready for it
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Background and rationale
More than two decades ago, Wise proposed his “anhedonia hypothesis” to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several authors have proposed alternative functions for dopamine with regard to motivation. Brain dopamine has been suggested to rather code for the preparatory aspects of behavior, while brain opioids seem to mediate the perception of the hedonic properties of rewards.
The main goal of this review is to reexamine dopamine and opioids involvement in feeding when different aspects such as the anticipatory, motivational and consummatory components of this behavior are taken into account, but also when the physiologic state of the organism and the palatability of the food are considered.
Results and conclusions
Altogether, the data presented point out for an implication of dopamine in the anticipatory/preparatory aspects of feeding more than on the motivational and consummatory aspects. However, dopamine involvement in the anticipatory/preparatory component of feeding seems specifically related to very relevant stimuli, such as highly palatable foods. On the other hand, our data, as well as those present in the literature, strongly suggest a role for opioids in food intake through their modulation of the hedonic perception of food. As a consequence, opioids are involved in those aspects of motivation driven by food palatability rather than by food homeostatic need.
KeywordsDopamine Opioids Motivation Feeding behavior Consummatory responses Palatability Anticipatory activity
The authors would like to thank Anne Fayoux, Stephane Lelgouach, and Pierre Gonzales for technical help and the University of Bordeaux 2, the Centre National de la Recherche Scientifique (CNRS), the action of scientific cooperation Ecos Sud A01S03, and the Conseil Régional d’Aquitaine for financial support. MF Barbano was supported by a doctoral grant from the CNRS.
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