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Psychopharmacology

, Volume 188, Issue 1, pp 42–52 | Cite as

Increased local and decreased remote functional connectivity at EEG alpha and beta frequency bands in opioid-dependent patients

  • Andrew A. FingelkurtsEmail author
  • Alexander A. Fingelkurts
  • Reetta Kivisaari
  • Taina Autti
  • Sergei Borisov
  • Varpu Puuskari
  • Olga Jokela
  • Seppo Kähkönen
Original Investigation

Abstract

Rationale

Although researchers now have a working knowledge of key brain structures involved in realization of actions of substance abuse and addiction, deeper understanding will require examination of network interactions between cortical neuronal assemblies and their subcortical tails in the effects of opioid dependence.

Objectives

Given that repeated exposure to opiates initiates a widespread reorganization of cortical regions, we predict that opioid dependence would result in a considerable reorganization of local and remote functional connectivity in the neocortex.

Methods

We applied the novel operational architectonics approach that enables us to estimate two local and remote functional cortex connectivities by means of electroencephalogram structural synchrony measure.

Results

In 22 opioid-dependent patients, we found the evidence that brain functional connectivity was indeed disrupted by chronic opioid abuse (i.e., the local functional connectivity increased and remote functional connectivity decreased in opioid abusers). This significant difference between “opioid” and “control” populations was the same for alpha and beta frequency bands. Additionally, significant negative relations between duration (years) of daily opioid abuse and the number/strength of functional connections in the posterior section of the cortex were found.

Keywords

Addiction Brain interactions Cortex Metastable states Opiate Opioid dependence Structural synchrony Synchronization 

Notes

Acknowledgements

The authors thank Carlos Neves (computer science specialist) for programming, technical, and IT support. We wish to thank Alexander Ilin for his consultation on the ICA codes. Parts of this work have been supported by Helsinki University Central Hospital, Academy of Finland, The Finnish Medical Foundation, Tekes, and BM-SCIENCE Centre. The experiments comply with the current laws of Finland.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Andrew A. Fingelkurts
    • 1
    • 2
    • 3
    Email author
  • Alexander A. Fingelkurts
    • 1
    • 2
    • 3
  • Reetta Kivisaari
    • 4
  • Taina Autti
    • 4
  • Sergei Borisov
    • 5
  • Varpu Puuskari
    • 6
  • Olga Jokela
    • 6
  • Seppo Kähkönen
    • 2
    • 3
  1. 1.BM-SCIENCE-Brain and Mind Technologies Research CentreEspooFinland
  2. 2.BioMag Laboratory, Engineering CentreHelsinki University Central HospitalHelsinkiFinland
  3. 3.Cognitive Brain Research Unit, Department of PsychologyUniversity of HelsinkiHelsinkiFinland
  4. 4.Helsinki Medical Imaging CenterHelsinki University Central HospitalHelsinkiFinland
  5. 5.Center for Functional and Molecular ImagingGeorgetown University Medical Center, Georgetown UniversityWashingtonUSA
  6. 6.Department of PsychiatryHelsinki University Central HospitalHelsinkiFinland

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