, Volume 186, Issue 4, pp 572–578 | Cite as

Effects of typical and atypical antipsychotics on glucose–insulin homeostasis and lipid metabolism in first-episode schizophrenia

  • Ren-Rong Wu
  • Jing-Ping Zhao
  • Zhe-Ning Liu
  • Jin-Guo Zhai
  • Xiao-Feng Guo
  • Wen-Bing Guo
  • Jing-Song Tang
Original Investigation



Glucose and lipid metabolism dysfunction is a significant side effect associated with antipsychotics. Although there are many studies about the linkages between drugs and metabolic dysfunction, most of these studies have compared the effects of two antipsychotics on only one metabolic measure: either glucose or lipid metabolism.


The present study aimed to investigate the effects of clozapine, olanzapine, risperidone, and sulpiride on glucose and lipid metabolism in first-episode schizophrenia.

Materials and methods

One hundred twelve schizophrenics were assigned randomly to receive clozapine, olanzapine, risperidone, or sulpiride for 8 weeks. Planned assessments included body mass index (BMI), waist-to-hip ratio, fasting glucose, insulin, C-peptide, insulin resistance index (IRI), cholesterol, and triglyceride. All measures were collected at baseline and at the end of the 8-week treatment.


After treatment, insulin, C-peptide, and IRI were significantly increased in the four groups, but not fasting glucose levels. Cholesterol and triglyceride levels were significantly increased in the clozapine and olanzapine groups. Patients treated with clozapine and olanzapine had higher fasting insulin, C-peptide, and IRI levels than those treated with risperidone and sulpiride. Among the four antipsychotics, the increases of mean BMI from high to low were as follows: clozapine, olanzapine, sulpiride, and risperidone.


This study confirmed that the four antipsychotic drugs were associated with an increase of insulin, C-peptide, and IRI. It was found that clozapine and olanzapine were associated with an increase in cholesterol and triglyceride levels. The effects of clozapine and olanzapine on the glucose and lipid metabolism outweighed those of risperidone and sulpiride.


Antipsychotic Clozapine Olanzapine Risperidone Sulpiride Metabolism Glucose Lipid 



The research was supported by National Key Technologies R&D Program in the 10th Five-year-plan grant 2004BA720A22 from the Ministry of Science and Technology of the People’s Republic of China.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Ren-Rong Wu
    • 1
  • Jing-Ping Zhao
    • 1
  • Zhe-Ning Liu
    • 1
  • Jin-Guo Zhai
    • 1
  • Xiao-Feng Guo
    • 1
  • Wen-Bing Guo
    • 1
  • Jing-Song Tang
    • 1
  1. 1.Institute of Mental Health of The Second Xiangya HospitalCentral South UniversityChangshaChina

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