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Psychopharmacology

, Volume 186, Issue 2, pp 191–200 | Cite as

Persistent dysfunctional frontal lobe activation in former smokers

  • Andres Neuhaus
  • Malek Bajbouj
  • Thorsten Kienast
  • Peter Kalus
  • Dorothea von Haebler
  • Georg Winterer
  • Jürgen GallinatEmail author
Original Investigation

Abstract

Objective

Chronic smoking and nicotine exposure are accompanied by impaired cognitive task performance, modulated cerebral activity in brain imaging studies, and neuritic damage in experimental animals. The profile of the described dysfunctions matches frontal lobe circuits which also play a role in reward processing and reinforcement behavior. However, it is largely unknown if cerebral dysfunctions are reversible or persist during long term abstinence.

Materials and methods

Cortical activation during auditory target processing (oddball task, P300 component) was recorded with 32-channel EEG in 247 healthy subjects consisting of 84 smokers, 53 former smokers (mean time of abstinence 11.9 years), and 110 never smokers.

Results

Both current smokers and former smokers exhibited significantly diminished P300 amplitudes (Cz, Pz) relative to never smokers. Neuroelectric source analysis (low resolution brain electromagnetic tomography) revealed a hypoactivation of the anterior cingulate, orbitofrontal, and prefrontal cortex in smokers compared to never smokers. A similar profile of hypoactivation was observed in former smokers.

Conclusion

For the first time, evidence is provided that dysfunctional activation of frontal lobe networks in smokers is also present in long term abstainers.

Keywords

Nicotine Smoking Target detection P300 LORETA 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Andres Neuhaus
    • 1
  • Malek Bajbouj
    • 1
  • Thorsten Kienast
    • 3
  • Peter Kalus
    • 3
  • Dorothea von Haebler
    • 3
  • Georg Winterer
    • 2
  • Jürgen Gallinat
    • 3
    • 4
    Email author
  1. 1.Department of Psychiatry and PsychotherapyCharité University MedicineBerlinGermany
  2. 2.Department of PsychiatryHeinrich-Heine University HospitalDüsseldorfGermany
  3. 3.Department of Psychiatry and PsychotherapyCharité University MedicineBerlinGermany
  4. 4.Department of Psychiatry and Psychotherapy, St. Hedwig HospitalCharité University MedicineBerlinGermany

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