Psychopharmacology

, Volume 179, Issue 1, pp 189–197

NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats

  • Anna-Maria Biondo
  • Robert L. H. Clements
  • David J. Hayes
  • Brendan Eshpeter
  • Andrew J. Greenshaw
Original Investigation

Abstract

Rationale

Recent experiments from this laboratory demonstrated synergistic effects of AMPA/kainate receptor blockade and D2/3 dopamine (DA) receptor stimulation on brain stimulation reward and locomotor activity.

Objectives

Using place conditioning, this study explored further the interaction between DA and glutamate (Glu) using the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801, the AMPA/kainate receptor antagonist NBQX, and the D2/3 DA receptor agonist 7-OH-DPAT.

Methods

Effects of these compounds, alone and combined, were measured in male Sprague–Dawley rats using an unbiased two-compartment place conditioning procedure.

Results

7-OH-DPAT (0.03–5.0 mg kg−1, s.c.) administered immediately prior to conditioning was ineffective; when administered 15 min prior to conditioning, only the highest dose (5.0 mg kg−1, s.c.) induced conditioned place preference (CPP). Acquisition of 7-OH-DPAT-induced CPP was blocked by MK-801 (0.06 or 0.13 mg kg−1, i.p.) or NBQX (0.5 μg) microinjected into the nucleus accumbens (NAS) shell subregion. Intra-NAS shell administration of 7-OH-DPAT (5.0 μg) or NBQX (0.5 μg), alone or combined, failed to induce place conditioning, and this lack of effect was not due to state dependency. Administration of MK-801 or 7-OH-DPAT (5.0 mg kg−1) during the conditioning phase acutely increased horizontal activity, but neither compound, alone or combined, induced conditioned locomotor effects.

Conclusions

Acquisition of place conditioning induced by systemic administration of 7-OH-DPAT is blocked by systemic NMDA receptor antagonism by MK-801 or by the AMPA/kainate receptor antagonist NBQX microinjected into the NAS shell subregion.

Keywords

7-OH-DPAT AMPA/kainate Dopamine Glutamate Locomotor activity MK-801 NMDA Place conditioning Place preference Reward 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Anna-Maria Biondo
    • 1
  • Robert L. H. Clements
    • 2
    • 3
  • David J. Hayes
    • 2
    • 3
  • Brendan Eshpeter
    • 4
  • Andrew J. Greenshaw
    • 2
    • 3
  1. 1.Department of SociologyUniversity of AlbertaEdmontonCanada
  2. 2.W.G. Dewhurst Laboratory, Department of Psychiatry, 1E7.44 Mackenzie Health Sciences CentreUniversity of AlbertaEdmontonCanada
  3. 3.Centre for NeuroscienceUniversity of AlbertaEdmontonCanada
  4. 4.Department of PsychologyUniversity of AlbertaEdmontonCanada

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