Psychopharmacology

, Volume 178, Issue 4, pp 461–470 | Cite as

Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence

  • Susan V. Heatherley
  • Robert C. Hayward
  • Helen E. Seers
  • Peter J. Rogers
Original Investigation

Abstract

Rationale

Many studies have found that caffeine consumed after overnight caffeine abstinence improves cognitive performance and mood. Much less is known, however, about the effects of caffeine after shorter periods of caffeine abstinence.

Objectives

The aim of this study was to measure the effects on psychomotor and cognitive performance, mood, hand steadiness, blood pressure and heart rate of caffeine administration after periods of 4, 6, and 8 h of caffeine abstinence.

Methods

Participants (n=49, 27 female) were moderate to moderate-high caffeine consumers (mean daily intake 370 mg/day). Following overnight caffeine abstinence, a ‘pre-dose’ of caffeine (1.2 mg/kg) was administered at 9 a.m., 11 a.m. or 1 p.m. The participants started a baseline battery of measurements at 4 p.m. before receiving caffeine (1.2 mg/kg) or placebo at 5 p.m. They then performed the battery of tests again, starting at 5:30 p.m. This was a double-blind, placebo-controlled, randomised study.

Results

Performance and mood measurements confirmed a psychostimulant action of caffeine (versus placebo), but only after 8 h of caffeine abstinence. Caffeine also increased blood pressure after 8-h abstinence, whereas hand steadiness was decreased and perception of task demand was increased by caffeine after 4 h, but not after 6- and 8-h abstinence.

Conclusions

A second cup-of-coffee equivalent dose of caffeine only reliably affected cognitive performance and mood after an 8-h interval between doses, but not after shorter intervals (when caffeine had some adverse effects). These results show that, apart from caffeine consumption soon after waking, the daily pattern of caffeine intake of many typical caffeine consumers is not well explained by the short-term psychostimulant effects of caffeine.

Keywords

Caffeine Drug withdrawal Cognitive performance Psychomotor performance Alertness Mood Tremor Blood pressure Heart rate 

References

  1. Arnold RW, Springer DT, Engel WK, Helveston EM (1993) The effect of wrist rest, caffeine, and oral timolol on the hand steadiness of ophthalmologists. Ann Ophthalmol 25:250–253Google Scholar
  2. Baddeley AD (1999) Essentials of human memory. Psychology Press, HoveGoogle Scholar
  3. Bovim G, Naess P, Helle J, Sand T (1995) Caffeine influence on the motor steadiness battery in neuropsychological tests. J Clin Exp Neuropsychol 17:472–476Google Scholar
  4. Broadbent DE, Broadbent HP, Jones JJ (1989) Time of day as an instrument for the analysis of attention. Eur J Cogn Psychol 1:69–94Google Scholar
  5. Bruce M, Scott N, Shine P, Lader M (1991) Caffeine withdrawal: a contrast of withdrawal symptoms in normal subjects who have abstained from caffeine for 24 hours and for 7 days. J Psychopharmacol 5:129–143Google Scholar
  6. Eriksen BA, Eriksen CW (1974) Effects of noise letters upon identification of target in a non-search task. Percept Psychophys 16:143–149Google Scholar
  7. Flaten MA, Blumenthal TD (1999) Caffeine-associated stimuli elicit conditioned responses: an experimental model of the placebo effect. Psychopharmacology 145:105–112CrossRefGoogle Scholar
  8. Heatherley SV, Hayward RC, Twyford HE, Moss EJ, Rogers PJ (2002) Psychostimulant and other effects of caffeine as a function of the duration of short-term caffeine abstinence. Behav Pharmacol 13:486Google Scholar
  9. James JE (1990) The influence of user status and anxious disposition on the hypertensive effects of caffeine. Int J Psychophysiol 10:171–179CrossRefGoogle Scholar
  10. James JE (1994) Does caffeine enhance or merely restore degraded performance? Neuropsychobiology 30:124–125Google Scholar
  11. James JE (1997) Understanding caffeine: a biobehavioral analysis. Sage, Thousand Oaks, CAGoogle Scholar
  12. James JE (1998) Acute and chronic effects of caffeine on performance, mood, and sleep. Neuropsychobiology 38:32–41CrossRefPubMedGoogle Scholar
  13. Leark RA, Dupuy T, Greenberg L, Corman C, Kindschi C (1996) Test of variables of attention: professional manual. Universal Attention Disorders, Los Alamitos, CAGoogle Scholar
  14. Lieberman HR, Wurtman RJ, Emde GG, Roberts C, Coviella ILG (1987) The effects of low doses of caffeine on human performance and mood. Psychopharmacology 92:308–312CrossRefGoogle Scholar
  15. Miller LS, Lombardo TW, Fowler SC (1998) Caffeine, but not time of day, increases whole-arm physiological tremor in non-smoking moderate users. Clin Exp Pharmacol Physiol 25:131–133Google Scholar
  16. Richardson NJ, Rogers PJ, Elliman NA, O’Dell RJ (1995) Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation. Pharmacol Biochem Behav 52:313–320CrossRefPubMedGoogle Scholar
  17. Robelin M, Rogers PJ (1998) Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence. Behav Pharmacol 9:611–618PubMedGoogle Scholar
  18. Rogers PJ, Dernoncourt C (1998) Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacol Biochem Behav 59:1039–1045CrossRefGoogle Scholar
  19. Rogers PJ, Richardson NJ (1994) Why do we like drinks that contain caffeine? Trends Food Sci Technol 4:108–111CrossRefGoogle Scholar
  20. Rogers PJ, Richardson NJ, Elliman, NA (1995) Overnight caffeine abstinence and negative reinforcement of preference for caffeine-containing drinks. Psychopharmacology 120:457–462Google Scholar
  21. Rogers PJ, Stephens S, Day JEL (1998) Contrasting performance effects of caffeine after overnight and chronic caffeine withdrawal. J Psychopharmacol 12:A13Google Scholar
  22. Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003) Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology 167:54–62PubMedGoogle Scholar
  23. Rozin P, Riff D, Mark M, Schull J (1984) Conditioned opponent responses in human tolerance to caffeine. Bull Psychon Soc 22:117–120Google Scholar
  24. Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology 152:167–173CrossRefGoogle Scholar
  25. Smit HJ, Rogers PJ (2002a) Effects of caffeine on mood. Pharmacopsychoecologia 15:231–257Google Scholar
  26. Smit HJ, Rogers PJ (2002b) Effects of ‘energy’ drinks on mood and mental performance: critical methodology. Food Qual Prefer 13:317–326CrossRefGoogle Scholar
  27. Smith AP, Maben A, Brockman P (1994) Effects of evening meals and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite 22:57–65CrossRefPubMedGoogle Scholar
  28. Snel J, Lorist MM (1998) Nicotine, caffeine and social drinking: behavior and brain function. Harwood, Amsterdam, NetherlandsGoogle Scholar
  29. Warburton DM (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology 119:66–70PubMedGoogle Scholar
  30. Warburton DM, Bersellini E (2001) An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology 158:322–328CrossRefPubMedGoogle Scholar
  31. Yeomans MR, Spetch H, Rogers PJ (1998) Conditioned flavour preference negatively reinforced by caffeine in human volunteers. Psychopharmacology 137:401–409CrossRefGoogle Scholar
  32. Yeomans MR, Ripley T, Davies LH, Rusted JM, Rogers PJ (2002) Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology 164:241–249CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Susan V. Heatherley
    • 1
  • Robert C. Hayward
    • 1
  • Helen E. Seers
    • 1
  • Peter J. Rogers
    • 1
  1. 1.Department of Experimental PsychologyUniversity of BristolBristolUK

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