Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol
- 1.2k Downloads
Sleep deprivation has a negative effect on cognitive and psychomotor performance and mood state, partially due to decreases in creatine levels in the brain. Therefore, creatine supplementation should lessen the negative effects of sleep deprivation.
The objective of this study was to examine the effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol.
Subjects were divided into a creatine group (n=10) and a placebo group (n=9). They took 5 g of creatine monohydrate or a placebo, dependent on their group, four times a time a day for 7 days, immediately prior to the experiment. The study was double blind. Subjects undertook tests of random movement generation (RMG), verbal and spatial recall, choice reaction time, static balance and mood state pre-test (0 h), after 6, 12 and 24 h of sleep deprivation, with intermittent exercise. They were tested for plasma concentrations of catecholamines and cortisol at 0 and 24 h.
At 24 h, the creatine group demonstrated significantly less change in performance from 0 h (Δ) in RMG, choice reaction time, balance and mood state. There were no significant differences between groups in plasma concentrations of catecholamines and cortisol. Norepinephrine and dopamine concentrations were significantly higher at 24 h than 0 h, but cortisol were lower.
Following 24-h sleep deprivation, creatine supplementation had a positive effect on mood state and tasks that place a heavy stress on the prefrontal cortex.
KeywordsStress Working memory Prefrontal cortex Choice reaction time Balance
This research was funded by the Howard Foundation of Cambridge, to whom the authors are very grateful.
- Baddeley AD (1986) Working memory. Oxford University Press, New YorkGoogle Scholar
- Dechent P, Pouwels PJW, Wilken B, Hanefeld F, Frahm J (1999) Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Regul Integr Comp Physiol 46:R698-R704Google Scholar
- Evans FJ (1978) Monitoring attention deployment by random number generation: an index to measure subjective randomness. Bull Psychon Soc 12:35–38Google Scholar
- Greenhaff PL, Casey A, Short AH, Harris R, Soderlund K, Hultman E (1993) Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci 84:567–571Google Scholar
- Grove J, Prapavessis H (1992) Preliminary evidence for the reliability and validity of an abbreviated profile of mood states. Int J Sport Psychol 23:93–109Google Scholar
- Heuer H, Kohlisch O, Klein W (2005) The effects of total sleep deprivation on generation of random sequences of key-presses, numbers and nouns. Q J Exp Psyhcol A 58:273–307Google Scholar
- McNair DM, Loer M, Droppleman LF (1971) Manual for the profile of mood states. Educational and Industrial Testing Sciences, San Diego, CAGoogle Scholar
- Meeusen R, Piacentini MF (2003) Exercise, fatigue, neurotransmission and the influence of the neuroendocrine axis. Adv Exp Med Biol 57:521–525Google Scholar
- Opstad PK (1991) Alterations in the morning plasma levels of hormones and the endocrine responses to bicycle exercise during prolonged strain. The significance of energy and sleep deprivation. Acta Endocrinol (Copenhagen) 125:14–22Google Scholar
- Towse JN, Neil D (1998) Analyzing human random generation behavior: a review of methods used and a computer program for describing performance. Behav Res Methods Instrum Comput 30:583–591Google Scholar