, Volume 184, Issue 3–4, pp 523–539 | Cite as

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

  • Edward D. LevinEmail author
  • F. Joseph McClernon
  • Amir H. Rezvani



Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction.


Critical for the development of nicotinic therapeutics is an understanding of the neurobehavioral bases for nicotinic involvement in cognitive function.


Specific and diverse cognitive functions affected by nicotinic treatments are reviewed, including attention, learning, and memory. The neural substrates for these behavioral actions involve the identification of the critical pharmacologic receptor targets, in particular brain locations, and how those incipient targets integrate with broader neural systems involved with cognitive function.


Nicotine and nicotinic agonists can improve working memory function, learning, and attention. Both α4β2 and α7 nicotinic receptors appear to be critical for memory function. The hippocampus and the amygdala in particular have been found to be important for memory, with decreased nicotinic activity in these areas impairing memory. Nicotine and nicotinic analogs have shown promise for inducing cognitive improvement. Positive therapeutic effects have been seen in initial studies with a variety of cognitive dysfunctions, including Alzheimer's disease, age-associated memory impairment, schizophrenia, and attention deficit hyperactivity disorder.


Discovery of the behavioral, pharmacological, and anatomic specificity of nicotinic effects on learning, memory, and attention not only aids the understanding of nicotinic involvement in the basis of cognitive function, but also helps in the development of novel nicotinic treatments for cognitive dysfunction. Nicotinic treatments directed at specific receptor subtypes and nicotinic cotreatments with drugs affecting interacting transmitter systems may provide cognitive benefits most relevant to different syndromes of cognitive impairment such as Alzheimer's disease, schizophrenia, and attention deficit hyperactivity disorder. Further research is necessary in order to determine the efficacy and safety of nicotinic treatments of these cognitive disorders.


Nicotine Attention Learning Memory Hippocampus Amygdala Alzheimer's disease Schizophrenia ADHD 



Work on this review was supported by NIH grants MH64494 and DA015756.


  1. Addy N, Levin ED (2002) Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. Neuropsychopharmacology 27:534–541CrossRefPubMedGoogle Scholar
  2. Addy N, Nakajama A, Levin E (2003) Nicotinic mechanisms of memory: effects of acute local DHbE and MLA infusions in the basolateral amygdala. Cogn Brain Res 16:51–57CrossRefGoogle Scholar
  3. Adler LE, Hoffer LJ, Griffith J, Waldo MC, Freedman R (1992) Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry 32:607–616CrossRefPubMedGoogle Scholar
  4. Adler LE, Hoffer LD, Wiser A, Freedman R (1993) Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry 150:1856–1861PubMedGoogle Scholar
  5. Adler LE, Olincy A, Waldo M, Harris JG, Griffith J, Stevens K, Flach K, Nagamoto H, Bickford P, Leonard S, Freedman R (1998) Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull 24:189–202PubMedGoogle Scholar
  6. Aggleton JP, Keith AB, Sahgal A (1991) Both fornix and anterior thalamic, but not mammillary, lesions disrupt delayed non-matching-to-position memory in rats. Behav Brain Res 44:151–161PubMedGoogle Scholar
  7. Allam MF, Campbell MJ, Hofman A, Del Castillo AS, Fernandez-Crehuet Navajas R (2004) Smoking and Parkinson's disease: systematic review of prospective studies. Mov Disord 19:614–621CrossRefPubMedGoogle Scholar
  8. Almeida OP, Hulse GK, Lawrence D, Flicker L (2002) Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case–control and cohort studies. Addiction 97:15–28CrossRefPubMedGoogle Scholar
  9. Arendash GW, Sanberg PR, Sengstock GJ (1995a) Nicotine enhances the learning and memory of aged rats. Pharmacol Biochem Behav 52:517–523CrossRefPubMedGoogle Scholar
  10. Arendash GW, Sengstock GJ, Sanberg PR, Kem WR (1995b) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res 674:252–259CrossRefPubMedGoogle Scholar
  11. Arthur D, Levin ED (2002) Chronic inhibition of alpha4beta2 nicotinic receptors in the ventral hippocampus of rats: impacts on memory and nicotine response. Psychopharmacology (Berl) 160:140–145CrossRefGoogle Scholar
  12. Attaway CM, Compton DM, Turner MD (1999) The effects of nicotine on learning and memory: a neuropsychological assessment in young and senescent Fischer 344 rats. Physiol Behav 67:421–431CrossRefPubMedGoogle Scholar
  13. Bacciottini L, Passani MB, Mannaioni PF, Blandina P (2001) Interactions between histaminergic and cholinergic systems in learning and memory. Behav Brain Res 124:183–194CrossRefPubMedGoogle Scholar
  14. Bancroft A, Levin ED (2000) Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory. Neuropharmacology 39:2770–2778CrossRefPubMedGoogle Scholar
  15. Bartus RT, Dean RL, Flicker C (1987) Cholinergic psychopharmacology: an integration of human and animal research on memory. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven, New York, pp 219–232Google Scholar
  16. Bernert G, Sustrova M, Sovcikova E, Seidl R, Lubec G (2001) Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome. J Neural Transm, Suppl 61:237–245Google Scholar
  17. Bettany JH, Levin ED (2001) Ventral hippocampal alpha7 nicotinic receptors and chronic nicotine effects on memory. Pharmacol Biochem Behav 70:467–474CrossRefPubMedGoogle Scholar
  18. Biederman J (1998) Attention-deficit/hyperactivity disorder: a life-span perspective. J Clin Psychiatry 7:4–16Google Scholar
  19. Bizzaro L, Stolerman IP (2003) Attentional effects of nicotine and amphetamine in rats at different levels of motivation. Psychopharmacology (Berl) 170:271–277CrossRefGoogle Scholar
  20. Blandina P, Efoudebe M, Cenni G, Mannaioni P, Passani MB (2004) Acetylcholine, histamine, and cognition: two sides of the same coin. Learn Mem 11:1–8CrossRefPubMedGoogle Scholar
  21. Brenner DE, Kukull WA, Vanbelle G, Bowen JD, McCormick WC, Teri L, Larson EB (1993) Relationship between cigarette smoking and Alzheimer's disease in a population-based case–control study. Neurology 43:293–300PubMedGoogle Scholar
  22. Brioni JD, Decker MW, Sullivan JP, Arneric SP (1997) The pharmacology of (−)-nicotine and novel cholinergic channel modulators. Adv Pharmacol 37:153–214PubMedGoogle Scholar
  23. Brody AL, Olmstead RE, London ED, Farahi J, Meyer JH, Grossman P, Lee GS, Huang J, Hahn EL, Mandelkern MA (2004) Smoking-induced ventral striatum dopamine release. Am J Epidemiol 161:1211–1218Google Scholar
  24. Buccafusco JJ, Jackson WJ (1991) Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol Aging 12:233–238CrossRefPubMedGoogle Scholar
  25. Buccafusco JJ, Jackson WJ, Terry AV, Marsh KC, Decker MW, Arneric SP (1995) Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: a novel cholinergic channel activator for memory enhancement. Psychopharmacology (Berl) 120:256–266CrossRefGoogle Scholar
  26. Castellanos FX, Tannock R (2002) Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev, Neurosci 3:617–628Google Scholar
  27. Chambers RA, Moore J, McEvoy JP, Levin ED (1996) Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology 15:587–594CrossRefPubMedGoogle Scholar
  28. Changeux JP (1990a) Functional architecture and dynamics of the nicotinic acetylcholine receptor: an allosteric ligand-gated ion channel. FIDA Research Foundation Neuroscience Award Lectures. Raven, New York, pp 21–168Google Scholar
  29. Changeux JP (1990b) The nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels. Trends Pharmacol Sci 11:485–492CrossRefPubMedGoogle Scholar
  30. Changeux JP, Bertrand D, Corringer PJ, Dehaene S, Edelstein S, Lena C, LeNovere N, Marubio L, Picciotto M, Zoli M (1998) Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res Brain Res Rev 26:198–216CrossRefPubMedGoogle Scholar
  31. Chen Z (2000) Effect of histamine H3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats. Acta Pharmacol Sin 21:905–910PubMedGoogle Scholar
  32. Chen Z, Chen JQ, Kamei C (2001) Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. Acta Pharmacol Sin 22:609–913PubMedGoogle Scholar
  33. Ciamei A, Aversano M, Cestari V, Castellano C (2001) Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice. Psychopharmacology (Berl) 154:126–130CrossRefGoogle Scholar
  34. Clementz BA, Geyer MA, Braff DL (1998) Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry 155:1691–1694PubMedGoogle Scholar
  35. Corrigall WA, Coen KM, Adamson KL (1994) Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653:278–284CrossRefPubMedGoogle Scholar
  36. Court J, Spurden D, Lloyd S, McKeith I, Ballard C, Cairns N, Kerwin R, Perry R, Perry E (1999) Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. J Neurochem 73:1590–1597CrossRefPubMedGoogle Scholar
  37. Court JA, Martin-Ruiz C, Graham A, Perry E (2000a) Nicotinic receptors in human brain: topography and pathology. J Chem Neuroanat 20:281–298CrossRefPubMedGoogle Scholar
  38. Court JA, Piggott MA, Lloyd S, Cookson N, Ballard CG, McKeith IG, Perry RH, Perry EK (2000b) Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience 98:79–87CrossRefPubMedGoogle Scholar
  39. Court J, Martin-Ruiz C, Piggott M, Sperden D, Griffiths M, Perry E (2001) Nicotinic receptor abnormalities in Alzheimer's disease. Biol Psychiatry 49:175–184CrossRefPubMedGoogle Scholar
  40. de Leon J, Dadvand M, Canuso C, White AO, Stanilla JK, Simpson GM (1995) Schizophrenia and smoking: an epidemiological survey in a state hospital. Am J Psychiatry 152:453–455PubMedGoogle Scholar
  41. Decker MW, McGaugh JL (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7:151–168CrossRefPubMedGoogle Scholar
  42. Decker MW, Majchrzak MJ (1992) Effects of systemic and intracerebroventricular administration of mecamylamine, a nicotine cholinergic antagonist, on spatial memory in rats. Psychopharmacology (Berl) 107:530–534CrossRefGoogle Scholar
  43. Decker MW, Majchrzak MJ, Anderson DJ (1992) Effects of nicotine on spatial memory deficits in rats with septal lesions. Brain Res 572:281–285CrossRefPubMedGoogle Scholar
  44. Decker MW, Curzon P, Brioni JD, Arneric SP (1994) Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats. Eur J Pharmacol 261:217–222CrossRefPubMedGoogle Scholar
  45. Decker MW, Brioni JD, Bannon AW, Arneric SP (1995) Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics—minireview. Life Sci 56:545–570CrossRefPubMedGoogle Scholar
  46. Depatie L, O'Driscoll GA, Holahan AL, Atkinson V, Thavundayil JX, Kin NN, Lal S (2002) Nicotine and behavioral markers of risk for schizophrenia: a double-blind, placebo-controlled, cross-over study. Neuropsychopharmacology 27:1056–1070CrossRefPubMedGoogle Scholar
  47. Downey KK, Pomerleau CS, Pomerleau OF (1996) Personality differences related to smoking and adult attention deficit hyperactivity disorder. J Subst Abuse 8:129–135CrossRefPubMedGoogle Scholar
  48. Eidi M, Zarrindast MR, Eidi A, Oryan S, Parivar K (2003) Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats. Eur J Pharmacol 465:91–96CrossRefPubMedGoogle Scholar
  49. Elrod K, Buccafusco JJ, Jackson WJ (1988) Nicotine enhances delayed matching-to-sample performance by primates. Life Sci 43:277–287CrossRefPubMedGoogle Scholar
  50. Fagerström KO, Pomerleau O, Giordani B, Stelson F (1994) Nicotine may relieve symptoms of Parkinson's disease. Psychopharmacology (Berl) 116:117–119CrossRefGoogle Scholar
  51. Felix R, Levin ED (1997) Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats. Neuroscience 81:1009–1017CrossRefPubMedGoogle Scholar
  52. Fu Y, Matta SG, James TJ, Sharp BM (1998) Nicotine-induced norepinephrine release in the rat amygdala and hippocampus is mediated through brainstem nicotinic cholinergic receptors. J Pharmacol Exp Ther 284:1188–1196PubMedGoogle Scholar
  53. Gatto GJ, Bohme GA, Caldwell WS, Letchworth SR, Traina VM, Obinu MC, Laville M, Reibaud M, Pradier LGD, Bencherif M (2004) TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects. CNS Drug Rev 10:147–166PubMedCrossRefGoogle Scholar
  54. Gorell JM, Rybicki BA, Johnson CC, Peterson EL (1999) Smoking and Parkinson's disease—a dose–response relationship. Neurology 52:115–119PubMedGoogle Scholar
  55. Gould E, Woolf NJ, Butcher LL (1989) Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei. Neuroscience 28:611–623CrossRefPubMedGoogle Scholar
  56. Granon S, Passetti F, Thomas KL, Dalley JW, Everitt BJ, Robbins TW (2000) Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex. J Neurosci 20:1208–1215PubMedGoogle Scholar
  57. Grigoryan GA, Mitchell SN, Hodges H, Sinden JD, Gray JA (1994) Are the cognitive-enhancing effects of nicotine in the rat with lesions to the forebrain cholinergic projection system mediated by an interaction with the noradrenergic system? Pharmacol Biochem Behav 49:511–521CrossRefPubMedGoogle Scholar
  58. Grilly DM (2000) A verification of psychostimulant-induced improvement in sustained attention in rats: effects of d-amphetamine, nicotine, and pemoline. Exp Clin Psychopharmacol 8:14–21CrossRefPubMedGoogle Scholar
  59. Grottick AJ, Higgins GA (2000) Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res 117:197–208CrossRefPubMedGoogle Scholar
  60. Guan ZZ, Zhang X, Blennow K, Nordberg A (1999) Decreased protein level of nicotinic receptor alpha 7 subunit in the frontal cortex from schizophrenic brain. NeuroReport 10:1779–1782PubMedGoogle Scholar
  61. Hahn B, Sharples CG, Wonnacott S, Shoaib M, Stolerman IP (2003) Attentional effects of nicotinic agonists in rats. Neuropharmacology 44:1054–1067CrossRefPubMedGoogle Scholar
  62. Harris JG, Kongs S, Allensworth D, Martin L, Tregellas J, Sullivan B, Zerbe G, Freedman R (2004) Effects of nicotine on cognitive deficits in schizophrenia. Neuropsychopharmacology 29:1378–1385CrossRefPubMedGoogle Scholar
  63. Heishman SJ, Taylor RC, Henningfield JE (1994) Nicotine and smoking: a review of effects on human performance. Exp Clin Psychopharmacol 2:1–51Google Scholar
  64. Hellstrom-Lindahl E, Mousavi M, Ravid R, Nordberg A (2004) Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients. Neurobiol Dis 15:351–360CrossRefPubMedGoogle Scholar
  65. Hiramatsu M, Yamatsu T, Kameyama T, Nabeshima T (2002) Effects of repeated administration of (−)-nicotine on AF64A-induced learning and memory impairment in rats. J Neural Transm 109:361–375CrossRefPubMedGoogle Scholar
  66. Hodges H, Allen Y, Sinden JD, Mitchell SN, Arendt T, Lantos PL, Gray JA (1991) The effect of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in rats. Behav Brain Res 43:7–28PubMedGoogle Scholar
  67. Howson AL, Batth S, Ilivitsky V, Boisjoli A, Jaworski M, Mahoney C, Knott VJ (2004) Clinical and attentional effects of acute nicotine treatment in Tourette's syndrome. Eur Psychiatry 19:102–112CrossRefPubMedGoogle Scholar
  68. Ishikawa A, Miyatake T (1993) Effects of smoking in patients with early-onset Parkinson's disease. J Neurol Sci 117:28–32CrossRefPubMedGoogle Scholar
  69. Jackson WJ, Elrod K, Buccafusco JJ (1989) Delayed matching-to-sample in monkeys as a model for learning and memory deficits: role of brain nicotinic receptors. In: Meyer EM, Simpkins JW, Yamamoto J (eds) Novel approaches to the treatment of Alzheimer's disease. Plenum, New York, pp 39–52Google Scholar
  70. Jarrard LE (1995) What does the hippocampus really do? Behav Brain Res 71:1–10CrossRefPubMedGoogle Scholar
  71. Jones S, Sudweeks S, Yakel JL (1999) Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci 22:555–561CrossRefPubMedGoogle Scholar
  72. Kalivas PW, Jackson D, Romanidies A, Wyndham L, Duffy P (2001) Involvement of pallidothalamic circuitry in working memory. Neuroscience 104:129–136CrossRefPubMedGoogle Scholar
  73. Kelton MC, Kahn HJ, Conrath CL, Newhouse PA (2000) The effects of nicotine on Parkinson's disease. Brain Cogn 43:274–282PubMedGoogle Scholar
  74. Kim JS, Levin ED (1996) Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats. Brain Res 725:231–240PubMedGoogle Scholar
  75. Kollins SH, McClernon FJ, Fuemmeler BF (2005) Association between smoking and ADHD symptoms in a population-based sample of young adults. Arch Gen Psychiatry (in press)Google Scholar
  76. Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K, Ackenheil M (2002) Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 5:111–113CrossRefPubMedGoogle Scholar
  77. Kumari V, Gray JA, ffytche DH, Mitterschiffthaler MT, Das M, Zachariah E, Vythelingum GN, Williams SC, Simmons A, Sharma T (2003) Cognitive effects of nicotine in humans: an fMRI study. NeuroImage 19:1002–1013CrossRefPubMedGoogle Scholar
  78. Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH (2000) Smoking and mental illness: a population-based prevalence study. JAMA 284:2606–2610CrossRefPubMedGoogle Scholar
  79. Lawrence NS, Ross TJ, Stein EA (2002) Cognitive mechanisms of nicotine on visual attention. Neuron 36:539–548CrossRefPubMedGoogle Scholar
  80. Lemay S, Chouinard S, Blanchet P, Masson H, Soland V, Beuter A, Bedard MA (2004) Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson's disease. Prog Neuro-psychopharmacol Biol Psychiatry 28:31–39CrossRefGoogle Scholar
  81. Levin ED (1992) Nicotinic systems and cognitive function. Psychopharmacology (Berl) 108:417–431CrossRefGoogle Scholar
  82. Levin ED (1997) Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat. Pharmacol Biochem Behav 58:899–902CrossRefPubMedGoogle Scholar
  83. Levin ED (1999) Persisting effects of chronic adolescent nicotine administration on radial-arm maze learning and response to nicotinic challenges. Neurobehavioral Teratology Society Annual Meeting, Keystone, COGoogle Scholar
  84. Levin ED (2000a) The role of nicotinic acetylcholine receptors in cognitive function. In: Clementi F, Gotti C, Fornasari D (eds) Handbook of experimental pharmacology: neuronal nicotinic receptors. Springer, Berlin Heidelberg New York, pp 587–602Google Scholar
  85. Levin ED (2000b) Use of the radial-arm maze to assess learning and memory. In: Buccafusco JJ (ed) Methods in behavioral pharmacology. CRC, New York, pp 189–199Google Scholar
  86. Levin ED (2001) Nicotine effects on attention deficit hyperactivity disorder. In: Levin ED (ed) Nicotinic receptors in the nervous system. CRC, New York, pp 251–260Google Scholar
  87. Levin ED (2002) Nicotinic receptor subtypes and cognitive function. J Neurobiol 53:633–640CrossRefPubMedGoogle Scholar
  88. Levin ED, Bowman RE (1986) Effects of the dopamine D2 receptor agonist, LY 171555, on radial arm maze performance in rats. Pharmacol Biochem Behav 25:83–88CrossRefPubMedGoogle Scholar
  89. Levin ED, Chen E (2004) Nicotinic involvement in memory function in zebrafish. Neurotoxicol Teratol 26:731–735CrossRefPubMedGoogle Scholar
  90. Levin ED, Christopher NC (2002) Persistence of nicotinic agonist RJR 2403 induced working memory improvement in rats. Drug Dev Res 55:97–103CrossRefGoogle Scholar
  91. Levin E, Christopher N (2003) Lobeline-induced learning improvements in rats in the radial-arm maze. Pharmacol Biochem Behav 76:133–139CrossRefPubMedGoogle Scholar
  92. Levin ED, Eisner B (1994) Nicotine interactions with D1 and D2 agonists: effects on working memory function. Drug Dev Res 31:32–37CrossRefGoogle Scholar
  93. Levin ED, Rose JE (1991) Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. Brain Res Bull 27:125–128CrossRefPubMedGoogle Scholar
  94. Levin ED, Rose JE (1992) Cognitive effects of D1 and D2 interactions with nicotinic and muscarinic systems. In: Levin ED, Decker MW, Butcher LL (eds) Neurotransmitter interactions and cognitive function. Berkhäuser, Boston, pp 144–158Google Scholar
  95. Levin ED, Rose JE (1995) Acute and chronic nicotinic interactions with dopamine systems and working memory performance. Ann NY Acad Sci 757:245–252PubMedGoogle Scholar
  96. Levin ED, Simon BB (1998) Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology (Berl) 138:217–230CrossRefGoogle Scholar
  97. Levin ED, Torry D (1996) Acute and chronic nicotine effects on working memory in aged rats. Psychopharmacology (Berl) 123:88–97CrossRefGoogle Scholar
  98. Levin ED, McGurk SR, Rose JE, Butcher LL (1989a) Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555. Pharmacol Biochem Behav 33:919–922CrossRefPubMedGoogle Scholar
  99. Levin ED, McGurk SR, South D, Butcher LL (1989b) Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze. Behav Neural Biol 51:270–277CrossRefPubMedGoogle Scholar
  100. Levin ED, Lee C, Rose JE, Reyes A, Ellison G, Jarvik M, Gritz E (1990a) Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol 53:269–276CrossRefPubMedGoogle Scholar
  101. Levin ED, Rose JE, McGurk SR, Butcher LL (1990b) Characterization of the cognitive effects of combined muscarinic and nicotinic blockade. Behav Neural Biol 53:103–112CrossRefPubMedGoogle Scholar
  102. Levin ED, Briggs SJ, Christopher NC, Rose JE (1992) Persistence of chronic nicotine-induced cognitive facilitation. Behav Neural Biol 58:152–158CrossRefPubMedGoogle Scholar
  103. Levin ED, Briggs SJ, Christopher NC, Rose JE (1993a) Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol 4:179–182PubMedGoogle Scholar
  104. Levin ED, Christopher NC, Briggs SJ, Rose JE (1993b) Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Cogn Brain Res 1:137–143CrossRefGoogle Scholar
  105. Levin ED, Briggs SJ, Christopher NC, Auman JT (1994) Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra. Brain Res 657:165–170CrossRefPubMedGoogle Scholar
  106. Levin ED, Rose JE, Abood L (1995) Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav 51:369–373CrossRefPubMedGoogle Scholar
  107. Levin ED, Christopher NC, Briggs SJ, Auman JT (1996a) Chronic nicotine-induced improvement of spatial working memory and D2 dopamine effects in rats. Drug Dev Res 39:29–35CrossRefGoogle Scholar
  108. Levin ED, Conners CK, Sparrow E, Hinton SC, Erhardt D, Meck WH, Rose JE, March J (1996b) Nicotine effects on adults with attention-deficit/hyperactivity disorder. Psychopharmacology (Berl) 123:55–63CrossRefGoogle Scholar
  109. Levin ED, Kim P, Meray R (1996c) Chronic nicotine effects on working and reference memory in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. Psychopharmacology (Berl) 127:25–30Google Scholar
  110. Levin ED, Toll K, Chang G, Christopher NC, Briggs SJ (1996d) Epibatidine, a potent nicotinic agonist: effects on learning and memory in the radial-arm maze. Med Chem Res 6:543–554Google Scholar
  111. Levin ED, Wilson W, Rose JE, McEvoy J (1996e) Nicotine–haloperidol interactions and cognitive performance in schizophrenics. Neuropsychopharmacology 15:429–436CrossRefPubMedGoogle Scholar
  112. Levin ED, Kaplan S, Boardman A (1997) Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. Behav Pharmacol 8:236–242PubMedGoogle Scholar
  113. Levin ED, Bettegowda C, Weaver T, Christopher NC (1998) Nicotine–dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav 61:335–340CrossRefPubMedGoogle Scholar
  114. Levin ED, Bettegowda C, Blosser J, Gordon J (1999a) AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol 10:675–680PubMedGoogle Scholar
  115. Levin ED, Christopher NC, Weaver T, Moore J, Brucato F (1999b) Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. Cogn Brain Res 7:405–410CrossRefGoogle Scholar
  116. Levin ED, Simon BB, Conners CK (2000) Nicotine effects and attention deficit disorder. In: Newhouse P, Piasecki M (eds) Nicotine in psychiatry: psychopathology and emerging therapeutics. Wiley, New York, pp 203–214Google Scholar
  117. Levin ED, Conners CK, Silva D, Canu W, March J (2001) Effects of chronic nicotine and methylphenidate in adults with ADHD. Exp Clin Psychopharmacol 9:83–90CrossRefPubMedGoogle Scholar
  118. Levin ED, Bradley A, Addy N, Sigurani N (2002) Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience 109:757–765CrossRefPubMedGoogle Scholar
  119. Levin ED, Sledge D, Baruah A, Addy N (2003) Hippocampal NMDA blockade and nicotinic effects on memory function. Behav Brain Res 61:489–495Google Scholar
  120. Levin ED, Blackwelder WP, Lau E, Brotherton J (2004a) Nicotinic alpha4-beta2 and alpha7 nicotinic antagonist effects in the mediodorsal thalamic nucleus and frontal cortex on memory function. Society for Neuroscience, Annual Meeting, San Diego, CAGoogle Scholar
  121. Levin ED, Weber E, Icenogle L (2004b) Baclofen interactions with nicotine in rats: effects on memory. Pharmacol Biochem Behav 79:343–348CrossRefPubMedGoogle Scholar
  122. Levin ED, Icenogle L, Farzad A (2005a) Nicotine-induced working memory improvement attenuated by the 5-HT2A antagonist ketanserin. Society for Research on Nicotine and Tobacco, Prague, Czech RepublicGoogle Scholar
  123. Levin ED, Limpuangthip J, Rachakonda T (2005b) Timing of nicotine effects on learning in zebrafish. Psychopharmacology (Berl) (in press)Google Scholar
  124. Lippiello PM, Bencherif M, Gray JA, Peters S, Grigoryan G, Hodges H, Collins AC (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther 279:1422–1429PubMedGoogle Scholar
  125. Luntz-Leybman V, Bickford PC, Freedman R (1992) Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res 587:130–136CrossRefPubMedGoogle Scholar
  126. Mancuso G, Warburton DM, Melen M, Sherwood N, Tirelli E (1999) Selective effects of nicotine on attentional processes. Psychopharmacology (Berl) 146:199–204CrossRefGoogle Scholar
  127. May-Simera H, Levin ED (2003) NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function. Cogn Brain Res 17:475–483CrossRefGoogle Scholar
  128. McClernon FJ, Gilbert DG, Radtke R (2003) Effects of transdermal nicotine on lateralized identification and memory interference. Hum Psychopharmacol 18:339–343CrossRefPubMedGoogle Scholar
  129. McEvoy JP, Freudenreich O, Levin ED, Rose JE (1995) Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology (Berl) 119:124–126CrossRefGoogle Scholar
  130. McGaugh JL, McIntyre CK, Power AE (2002) Amygdala modulation of memory consolidation: interaction with other brain systems. Neurobiol Learn Mem 78:539–552CrossRefPubMedGoogle Scholar
  131. McGaughy J, Decker MW, Sarter M (1999) Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl) 144:175–182CrossRefGoogle Scholar
  132. McGurk SR, Levin ED, Butcher LL (1989a) Nicotinic–dopaminergic relationships and radial-arm maze performance in rats. Behav Neural Biol 52:78–86CrossRefPubMedGoogle Scholar
  133. McGurk SR, Levin ED, Butcher LL (1989b) Radial-arm maze performance in rats is impaired by a combination of nicotinic–cholinergic and D2 dopaminergic antagonist drugs. Psychopharmacology (Berl) 99:371–373CrossRefGoogle Scholar
  134. Meguro K, Yamaguchi S, Arai H, Nakagawa T, Doi C, Yamada M, Ikarashi Y, Maruyama Y, Sasaki H (1994) Nicotine improves cognitive disturbance in senescence-accelerated mice. Pharmacol Biochem Behav 49:769–772CrossRefPubMedGoogle Scholar
  135. Mirza NR, Bright JL (2001) Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent. Psychopharmacology (Berl) 154:8–12CrossRefGoogle Scholar
  136. Mirza NR, Stolerman IP (1998) Nicotine enhances sustained attention in the rat under specific task conditions. Psychopharmacology (Berl) 138:266–274CrossRefGoogle Scholar
  137. Mitchell SN, Brazell MP, Schugens MM, Gray JA (1990) Nicotine-induced catecholamine synthesis after lesions to the dorsal or ventral noradrenergic bundle. Eur J Pharmacol 179:383–391CrossRefPubMedGoogle Scholar
  138. Mitchell AS, Dalrymple-Alford JC, Christie MA (2002) Spatial working memory and the brainstem cholinergic innervation to the anterior thalamus. J Neurosci 22:1922–1928PubMedGoogle Scholar
  139. Moragrega I, Carrasco MC, Vicens P, Redolat R (2003) Spatial learning in male mice with different levels of aggressiveness: effects of housing conditions and nicotine administration. Behav Brain Res 147:1–8CrossRefPubMedGoogle Scholar
  140. Morens DM, Grandinetti A, Reed D, White LR, Ross GW (1995) Cigarette smoking and protection from Parkinson's disease: false association or etiologic clue? Neurology 45:1041–1051PubMedGoogle Scholar
  141. Muir JL, Everitt BJ, Robbins TW (1995) Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology (Berl) 118:82–92CrossRefGoogle Scholar
  142. Myers CS, Robles O, Kakoyannis AN, Sherr JD, Avila MT, Blaxton TA, Thaker GK (2004) Nicotine improves delayed recognition in schizophrenic patients. Psychopharmacology (Berl) 174:334–340Google Scholar
  143. Newhouse PA, Sunderland T, Tariot PN, Blumhardt CL, Weingartner H, Mellow A, Murphy DL (1988) Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology (Berl) 95:171–175Google Scholar
  144. Ohno M, Yamamoto T, Watanabe S (1993) Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats. Pharmacol Biochem Behav 45:89–93CrossRefPubMedGoogle Scholar
  145. Ono K, Hasegawa K, Yamada M, Naiki H (2002) Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro. Biol Psychiatry 52:880–886CrossRefPubMedGoogle Scholar
  146. Papke RL, Webster JC, Lippiello PM, Bencherif M, Francis M (2000) The activation and inhibition of human nicotinic acetylcholine receptor by RJR-2403 indicate a selectivity for the alpha4beta2 receptor subtype. J Neurochem 75:204–216CrossRefPubMedGoogle Scholar
  147. Passetti F, Dalley JW, Robbins TW (2003) Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task. Psychopharmacology (Berl) 165:136–145Google Scholar
  148. Pomerleau OF, Downey KK, Stelson FW, Pomerleau CS (1995) Cigarette smoking in adult patients diagnosed with attention deficit hyperactivity disorder. J Subst Abuse 7:373–378CrossRefPubMedGoogle Scholar
  149. Potter AS, Newhouse PA (2004) Effects of acute nicotine administration on behavioral inhibition in adolescents with attention-deficit/hyperactivity disorder. Psychopharmacology (Berl) 176:183–194CrossRefGoogle Scholar
  150. Potter A, Corwin J, Lang J, Piasecki M, Lenox R, Newhouse PA (1999) Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease. Psychopharmacology (Berl) 142:334–342CrossRefGoogle Scholar
  151. Puma C, Deschaux O, Molimard R, Bizot JC (1999) Nicotine improves memory in an object recognition task in rats. Eur Neuropsychopharmacol 9:323–327CrossRefPubMedGoogle Scholar
  152. Quik M, Jeyarasasingam G (2000) Nicotinic receptors and Parkinson's disease. Eur J Pharmacol 393:223–230CrossRefPubMedGoogle Scholar
  153. Rezvani AH, Levin ED (2001) Cognitive effects of nicotine. Biol Psychiatry 49:258–267CrossRefPubMedGoogle Scholar
  154. Rezvani AH, Levin ED (2003a) Nicotine interactions with the NMDA glutaminergic antagonist dizocilpine and attentional function. Eur J Pharmacol 465:83–90CrossRefPubMedGoogle Scholar
  155. Rezvani AH, Levin ED (2003b) Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats. Pharmacol Biochem Behav 76:75–83CrossRefPubMedGoogle Scholar
  156. Rezvani AH, Bushnell PJ, Levin ED (2002) Nicotine and mecamylamine effects on choice accuracy in an operant signal detection task. Psychopharmacology (Berl) 164:369–375CrossRefGoogle Scholar
  157. Rezvani AH, Caldwell DP, Levin ED (2004) Nicotine-antipsychotic drug interactions and attentional performance. Eur J Pharmacol 486:175–182CrossRefPubMedGoogle Scholar
  158. Rezvani AH, Caldwell DP, Levin ED (2005) Nicotine-serotonergic drug interactions and attentional performance in rats. Psychopharmacology (Berl) 179:521–528CrossRefGoogle Scholar
  159. Riekkinen P Jr, Riekkinen M, Sirvio J (1993) Cholinergic drugs regulate passive avoidance performance via the amygdala. J Pharmacol Exp Ther 267:1484–1492PubMedGoogle Scholar
  160. Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163:362–380CrossRefGoogle Scholar
  161. Rochford J, Sen AP, Quirion R (1996) Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat. J Pharmacol Exp Ther 277:1267–1275PubMedGoogle Scholar
  162. Rubboli F, Court JA, Sala C, Morris C, Chini B, Perry E, Clementi F (1994) Distribution of nicotinic receptors in the human hippocampus and thalamus. Eur J Neurosci 6:1596–1604PubMedGoogle Scholar
  163. Ruotsalainen S, Miettinen R, MacDonald E, Koivisto E, Sirvio J (2000) Blockade of muscarinic, rather than nicotinic, receptors impairs attention, but does not interact with serotonin depletion. Psychopharmacology (Berl) 148:111–123CrossRefGoogle Scholar
  164. Rupniak NMJ, Iversen SD (1989) Comparison of cognitive facilitation by cholinomimetic drugs in two primate memory tests. J Psychopharmacol 3:52PGoogle Scholar
  165. Sahakian BJ, Coull JT (1994) Nicotine and tetrahydroaminoacradine: evidence for improved attention in patients with dementia of the Alzheimer type. Drug Dev Res 31:80–88CrossRefGoogle Scholar
  166. Salokangas RKR, Vilkman H, Ilonen T, Taiminen T, Bergman J, Haaparanta M, Solin O, Alanen A, Syvalahti E, Hietala J (2000) High levels of dopamine activity in the basal ganglia of cigarette smokers. Am J Psychiatry 157:632–634CrossRefPubMedGoogle Scholar
  167. Seidl R, Tiefenthaler M, Hauser E, Lubec G (2000) Effects of transdermal nicotine on cognitive performance in Down's syndrome. Lancet 356:1409–1410CrossRefPubMedGoogle Scholar
  168. Shoaib M, Schindler CW, Goldberg SR (1997) Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition. Psychopharmacology (Berl) 129:35–43CrossRefGoogle Scholar
  169. Shytle RD, Silver AA, Wilkinson BJ, Sanberg PR (2002) A pilot controlled trial of transdermal nicotine in the treatment of attention deficit hyperactivity disorder. World J Biol Psychiatry 3:150–155PubMedCrossRefGoogle Scholar
  170. Smith RC, Singh A, Infante M, Khandat A, Kloos A (2002) Effects of cigarette smoking and nicotine nasal spray on psychiatric symptoms and cognition in schizophrenia. Neuropsychopharmacology 27:479–797CrossRefPubMedGoogle Scholar
  171. Snaedal J, Johannesson T, Jonsson JE, Gylfadottir G (1996) The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer's disease. Dementia 7:47–52PubMedGoogle Scholar
  172. Socci DJ, Sanberg PR, Arendash GW (1995) Nicotine enhances Morris water maze performance of young and aged rats. Neurobiol Aging 16:857–860CrossRefPubMedGoogle Scholar
  173. Stokes KA, Best PJ (1988) Mediodorsal thalamic lesions impair radial maze performance in the rat. Behav Neurosci 102:294–300CrossRefPubMedGoogle Scholar
  174. Stolerman IP, Mirza NR, Shoaib M (1995) Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Med Res Rev 15:47–72PubMedGoogle Scholar
  175. Stolerman IP, Mirza NR, Hahn B, Shoaib M (2000) Nicotine in an animal model of attention. Eur J Pharmacol 393:147–154CrossRefPubMedGoogle Scholar
  176. Terry AV, Buccafusco JJ, Jackson WJ, Zagrodnik S, Evans-Martin FF, Decker MW (1996) Effects of stimulation or blockade of central nicotinic-cholinergic receptors on performance of a novel version of the rat stimulus discrimination task. Psychopharmacology (Berl) 123:172–181CrossRefGoogle Scholar
  177. Terry AV, Risbrough VB, Buccafusco JJ, Menzaghi F (2002) Effects of (+/−)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. J Pharmacol Exp Ther 301:284–292CrossRefPubMedGoogle Scholar
  178. Utsuki T, Shoaib M, Holloway HW, Ingram DK, Wallace WC, Haroutunian V, Sambamurti K, Lahiri DK, Greig NH (2002) Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat. J Alzheimer's Dis 4:405–415Google Scholar
  179. Van Kampen M, Selbach K, Schneider R, Schiegel E, Boess F, Schreiber R (2004) AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. Psychopharmacology (Berl) 172:375–383CrossRefGoogle Scholar
  180. Vicens P, Carrasco MC, Redolat R (2003) Effects of early training and nicotine treatment on the performance of male NMRI mice in the water maze. Neural Plast 10:303–317PubMedGoogle Scholar
  181. Vidal C (1996) Nicotinic receptors in the brain. Molecular biology, function, and therapeutics. Mol Chem Neuropathol 28:3–11PubMedGoogle Scholar
  182. Wang PN, Wang SJ, Hong CJ, Liu TT, Fuh JL, Chi CW, Liu CY, Liu HC (1997) Risk factors for Alzheimer's disease: a case–control study. Neuroepidemiology 16:234–240PubMedGoogle Scholar
  183. Warburton DM (1992) Nicotine as a cognitive enhancer. Prog Neuro-psychopharmacol Biol Psychiatry 16:181–219CrossRefGoogle Scholar
  184. Warburton EC, Baird AL, Morgan A, Muir JL, Aggleton JP (2000) Disconnecting hippocampal projections to the anterior thalamus produces deficits on tests of spatial memory in rats. Eur J Neurosci 12:1714–1726CrossRefPubMedGoogle Scholar
  185. Weiser M, Reichenberg A, Grotto I, Yasvitzky R, Rabinowitz J, Lubin G, Nahon D, Knobler HY, Davidson M (2004) Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. Am J Psychiatry 161:1219–1223CrossRefPubMedGoogle Scholar
  186. White HK, Levin ED (1999) Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. Psychopharmacology (Berl) 143:158–165CrossRefGoogle Scholar
  187. White HK, Levin ED (2004) Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. Psychopharmacology (Berl) 171:465–471CrossRefGoogle Scholar
  188. Wilens TE, Biederman J, Spencer TJ, Bostic J, Prince J, Monuteaux MC, Soriano J, Fine C, Abrams A, Rater M, Polisner D (1999) A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder. Am J Psychiatry 156:1931–1937PubMedGoogle Scholar
  189. Wilson AL, Langley LK, Monley J, Bauer T, Rottunda S, McFalls E, Kovera C, McCarten JR (1995) Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety. Pharmacol Biochem Behav 51:509–514CrossRefPubMedGoogle Scholar
  190. Wonnacott S, Irons J, Rapier C, Thorne B, Lunt GG (1989) Presynaptic modulation of transmitter release by nicotinic receptors. In: Nordberg A, Fuxe K, Holmstedt B, Sundwall A (eds) Progress in brain research. Elsevier Science Publishers B.V., pp 157–163Google Scholar
  191. Woodruff-Pak DS, Green JT, Coleman-Valencia C, Pak JT (2000) A nicotinic cholinergic agonist (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbits. Exp Aging Res 26:323–336CrossRefPubMedGoogle Scholar
  192. Yamazaki Y, Hamaue N, Sumikawa K (2002) Nicotine compensates for the loss of cholinergic function to enhance long-term potentation induction. Brain Res 946:148–152CrossRefPubMedGoogle Scholar
  193. Yilmaz O, Kanit L, Okur BE, Pogun S (1997) Effects of nicotine on active avoidance learning in rats: sex differences. Behav Pharmacol 8:253–260PubMedGoogle Scholar
  194. Young J, Finalyson K, Spratt C, Marston H, Crawford N, Kelly J, Sharkey J (2004) Nicotine improves sustained attention in mice: evidence for involvement of the alpha 7 nicotinic acetylcholine receptor. Neuropsychopharmacology 29:891–900CrossRefPubMedGoogle Scholar
  195. Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingsson T, Lewis G (2003) Investigating the association between cigarette smoking and schizophrenia in a cohort study. Am J Psychiatry 160:2216–2221CrossRefPubMedGoogle Scholar
  196. Zhou M, Suskiw JB (2004) Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure. Brain Res 999:142–147CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Edward D. Levin
    • 1
    Email author
  • F. Joseph McClernon
    • 1
  • Amir H. Rezvani
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA

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