Psychopharmacology

, Volume 182, Issue 4, pp 588–596 | Cite as

Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats

  • Emily M. Jutkiewicz
  • Kenner C. Rice
  • John R. Traynor
  • James H. Woods
Original Investigation

Abstract

Rationale

Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use.

Objective

The present study tests the hypothesis that the rate of delta-opioid agonist administration greatly contributes to the convulsive properties, but not the antidepressant-like effects, of delta-opioid agonists.

Materials and methods

The delta-opioid agonist SNC80 (1, 3.2, and 10 mg kg−1 or vehicle) was administered to Sprague–Dawley rats by intravenous infusion over different durations of time (20 s, 20, or 60 min). Convulsions were measured by observation prior to determining antidepressant-like effects in the forced swim test.

Results

Slowing the rate of SNC80 administration minimized delta agonist-induced convulsions without altering the effects of SNC80 in the forced swim test.

Conclusions

These data suggest that delta agonist-induced antidepressant properties are independent of convulsive effects, and that it may be possible to eliminate the convulsions produced by delta agonists, further promoting their potential clinical utility.

Keywords

Delta-opioid receptor Antidepressants Convulsions Forced swim test Rats SNC80 Infusion rate 

Notes

Acknowledgements

This work was supported by grants from the US Public Health Service Grants DA00254, T32 GM07767, and T32 DA07267.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Emily M. Jutkiewicz
    • 1
  • Kenner C. Rice
    • 2
  • John R. Traynor
    • 1
  • James H. Woods
    • 1
  1. 1.Department of PharmacologyUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.NIHBethesdaUSA

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