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Psychopharmacology

, Volume 179, Issue 3, pp 559–566 | Cite as

Impaired perception of self-motion (heading) in abstinent ecstasy and marijuana users

  • M. RizzoEmail author
  • C. T. J. Lamers
  • C. G. Sauer
  • J. G. Ramaekers
  • A. Bechara
  • G. J. Andersen
Original Investigation

Abstract

Rationale

Illicit drug use can increase driver crash risk due to loss of control over vehicle trajectory. This study asks, does recreational use of ±3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) and tetrahydrocannabinol (THC; marijuana) impair cognitive processes that help direct our safe movement through the world?

Objective

This study assesses the residual effects of combined MDMA/THC use, and of THC use alone, upon perceived trajectory of travel.

Methods

Perception of self-motion, or heading, from optical flow patterns was assessed using stimuli comprising random dot ground planes presented at three different densities and eight heading angles (1, 2, 4 and 8° to the left or right). On each trial, subjects reported if direction of travel was to the left or the right.

Results

Results showed impairments in both drug groups, with the MDMA/THC group performing the worst.

Conclusions

The finding that these psychoactive agents adversely affect heading perception, even in recently abstinent users, raises potential concerns about MDMA use and driving ability.

Keywords

MDMA Driving THC Substance abuse Visual motion 

Notes

Acknowledgements

This study was supported by NIH PO NS 19632 and NIA AG 17177.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Rizzo
    • 1
    Email author
  • C. T. J. Lamers
    • 2
  • C. G. Sauer
    • 3
  • J. G. Ramaekers
    • 2
  • A. Bechara
    • 1
  • G. J. Andersen
    • 3
  1. 1.Division of Neuroergonomics and Division of Behavioral Neurology and Cognitive Neuroscience, Department of NeurologyThe University of Iowa Carver College of MedicineIowa CityUSA
  2. 2.Experimental Psychopharmacology Unit, Department of Neurocognition, Brain and Behaviour InstituteMaastricht UniversityMaastrichtThe Netherlands
  3. 3.Department of PsychologyUniversity of CaliforniaRiversideUSA

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