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Psychopharmacology

, Volume 178, Issue 2–3, pp 351–352 | Cite as

Tolerance to baclofen’s sedative effect in alcohol-addicted patients: no dissipation after a period of abstinence

  • Giovanni Addolorato
  • Lorenzo Leggio
  • Ludovico Abenavoli
  • Fabio Caputo
  • Giovanni Gasbarrini
Letter to the editors

Keywords

Baclofen Sedative Effect GABAB Receptor Alcohol Withdrawal Alcoholic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Addolorato G, Caputo F, Capristo E, Colombo G, Gessa GL, Gasbarrini G (2000) Ability of baclofen in reducing alcohol craving and intake. II. Preliminary clinical evidence. Alcohol Clin Exp Res 24:67–71CrossRefPubMedGoogle Scholar
  2. Addolorato G, Caputo F, Capristo E, Domenicali M, Bernardi M, Janiri L, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002a) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37:504–508CrossRefPubMedGoogle Scholar
  3. Addolorato G, Caputo F, Capristo E, Janiri L, Bernardi M, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002b) Rapid suppression of alcohol withdrawal syndrome by baclofen. Am J Med 112:226–229CrossRefPubMedGoogle Scholar
  4. Addolorato G, Leggio L, Abenavoli L, De Lorenzi G, Parente A, Caputo F, Janiri L, Capristo E, Rapaccini GL, Gasbarrini G (2003) Suppression of alcohol delirium tremens by baclofen administration: a case report. Clin Neuropharmacol 26:258–262CrossRefPubMedGoogle Scholar
  5. Besheer J, Lepoutre V, Hodge CW (2004) GABAb receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice. Psychopharmacology 174:358–366CrossRefPubMedGoogle Scholar
  6. Colombo G, Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Addolorato G, Gessa GL (2000) Ability of baclofen in reducing alcohol intake and withdrawal severity. I. Preclinical evidence. Alcohol Clin Exp Res 24:58–66CrossRefPubMedGoogle Scholar
  7. Colombo G, Serra S, Brunetti G, Atzori G, Pani M, Vacca G, Addolorato G, Froestl W, Carai MAM, Gessa GL (2002) The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats. Alcohol Alcohol 37:499–503CrossRefPubMedGoogle Scholar
  8. Flannery BA, Garbutt JC, Cody MW, Renn W, Grace K, Osborne M, Crosby K, Morreale M, Trivette A (2004) Baclofen for alcohol dependence: a preliminary open-label study. Alcohol Clin Exp Res (in press)Google Scholar
  9. National Institute on Alcohol Abuse and Alcoholism (2004) Neuroscience research and therapeutic targets. Alcohol Alert 61:1–6Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Giovanni Addolorato
    • 1
  • Lorenzo Leggio
    • 1
  • Ludovico Abenavoli
    • 1
  • Fabio Caputo
    • 1
  • Giovanni Gasbarrini
    • 1
  1. 1.Institute of Internal MedicineCatholic University of RomeRomeItaly

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