Olanzapine attenuates cue-elicited craving for tobacco
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Recent biological conceptualizations of craving and addiction have implicated mesolimbic dopamine activity as a central feature of the process of addiction. Imaging, and pharmacological studies have supported a role for dopaminergic structures in cue-elicited craving for tobacco.
If mesolimbic dopamine activity is associated with cue-elicited craving for tobacco, a dopamine antagonist should attenuate cue-elicited craving for tobacco. Thus, the aim of the present study was to determine whether an atypical antipsychotic (olanzapine, 5 mg) decreased cue-elicited craving for tobacco.
Participants were randomly assigned to 5 days of pretreatment with olanzapine (5 mg; n=31) or were randomly assigned to 5 days of a matching placebo (n=28). Approximately 8 h after the last dose, participants were exposed to a control cue (pencil) followed by exposure to smoking cues. Participants subsequently smoked either nicotine cigarettes or de-nicotinized cigarettes.
Olanzapine attenuated cue-elicited craving for tobacco but did not moderate the subjective effects of smoking.
This study represents one of the first investigations of the effect of atypical antipsychotics on cue-elicited craving for tobacco. The results suggest that medications with similar profiles may reduce cue-elicited craving, which in turn, may partially explain recent observations that atypical antipsychotics may reduce substance use.
KeywordsSmoking Nicotine Craving Olanzapine
This research was supported by grants from the Eli Lilly & Company and the National Cancer Institute (1R21CA81637) as well as grant 2 M01-RR00051 from the General Clinical Research Center Program of the National Center for Research Resources, National Institutes of Health.
- Caskey NH, Jarvik ME, Wirshing WC (1999) The effects of dopaminergic D2 stimulation and blockade on smoking behavior. Exp Clin Psychopharmacol 7:72–78Google Scholar
- Dawe S, Gerada C, Russell MA, Gray JA (1995) Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117:110–115Google Scholar
- Hutchison KE, Niaura R, Swift R (1999) Smoking cues decrease prepulse inhibition of the startle response and increase subjective craving in humans. Exp Clin Psychopharmacol 7:250–256Google Scholar
- Hutchison KE, Niaura R, Swift RM (2000) The effects of smoking high nicotine cigarettes on prepulse inhibition, startle latency, and subjective responses. Psychopharmacology 150:244–252Google Scholar
- Shiffman S, Paty JA, Gnys M, Kassel JA, Hickcox M (1996) First lapses to smoking: within-subjects analysis of real-time reports. J Consult Clin Psychol 64:366–379Google Scholar
- Shiffman S, Johnston JA, Khayrallah M, Elash CA, Gwaltney CJ, Paty JA, Gnys M, Evoniuk G, DeVeaugh-Geiss J (2000b) The effect of bupropion on nicotine craving and withdrawal. Psychopharmacology 148:33–40Google Scholar
- Tiffany ST (1995) The role of cognitive factors in reactivity to drug cues. In: Drummond STTDC, Glautier S, Remington B (eds) Addictive behaviour: cue exposure theory and practice, vol 7. Wiley, New York, pp 137–165Google Scholar