, Volume 173, Issue 1–2, pp 227–228

Case report: successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine

  • Jaskaran Singh
  • Carlos A. ZarateJr
  • Andrew D. Krystal
Letter to the Editors


  1. Calabrese JR, Bowden CL, Sachs GS et al. (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 60:79–88PubMedGoogle Scholar
  2. Calabrese JR, Sullivan JR, Bowden CL et al. (2002) Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry 63:1012–1019PubMedGoogle Scholar
  3. Ghaemi SN, Hsu DJ, Soldani F et al. (2003) Antidepressants in bipolar disorder: the case for caution. Bipolar Disord 5:421–433CrossRefPubMedGoogle Scholar
  4. Goodwin GM (2003) Evidence-based guidelines for treating bipolar disorder: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 17:149–173; discussion 147CrossRefPubMedGoogle Scholar
  5. Goodwin,FK, Jamison KR (1990) Manic-depressive Illness. Oxford University Press, New YorkGoogle Scholar
  6. Keck J, Paul E, Nelson EB, McElroy SL (2003) Advances in the pharmacologic treatment of bipolar depression. Biol Psychiatry 53:671–679CrossRefPubMedGoogle Scholar
  7. Prakriya M, Mennerick S (2000) Selective depression of low-release probability excitatory synapses by sodium channel blockers. Neuron 26:671–682PubMedGoogle Scholar
  8. Simpson SG, Jamison KR (1999) The risk of suicide in patients with bipolar disorders. J Clin Psychiatry 60 (Suppl 2):53–56; discussion 75–76, 113–116Google Scholar
  9. Zarate CA Jr, Payne JL, Quiroz JA, Sporn J, Denicoff KD, Luckenbaugh D, Charney DS, Manji HK (2004) An open-label trial of riluzole in treatment-resistant major depression. Am J Psychiatry 161:171–174CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Jaskaran Singh
    • 1
  • Carlos A. ZarateJr
    • 1
  • Andrew D. Krystal
    • 2
  1. 1.Laboratory of Molecular PathophysiologyNational Institutes of Mental HealthBethesdaUSA
  2. 2.Duke University Medical CenterDurhamUSA

Personalised recommendations