Response to: Parrott AC, Buchanan T, Heffernan TM, Scholey A, Ling J, Rodgers J (2003) Parkinson’s disorder, psychomotor problems and dopaminergic neurotoxicity in recreational ecstasy/MDMA users. Psychopharmacology 167(4):449–450
To the Editors; In their recent letter, Parrott and colleagues discussed the human implications of findings of dopaminergic neurotoxicity in non-human primates after repeated doses of MDMA (three injections of 2 mg/kg within 6 h) (Ricaurte et al. 2002). Parrott and colleagues are concerned that like the known neurotoxin MPTP, MDMA might only produce observable effects in a minority of ecstasy users. They supported their concerns by citing a survey conducted over the internet that yielded reports of tremors and twitches in 20% of 282 ecstasy users. However, scientists disagree on the human implications of Ricaurte’s findings, and an examination of the literature fails to support a link between ecstasy use and dopaminergic neurotoxicity or motor problems (Holden 2002).
The MDMA dose regimen used by Ricaurte and colleagues produced 20% mortality in their animals, a figure that far exceeds the estimated percentage of deaths in ecstasy users (Gore 1999; Gill et al. 2003; Henry and Rella 2001...
KeywordsMPTP Ecstasy MDMA Ecstasy User Motor Problem
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