, Volume 171, Issue 1, pp 6–12 | Cite as

Ethical issues in the use of animals in biomedical and psychopharmocological research

  • John P. Gluck
  • Jordan Bell



The ethical debate concerning the use of animals in biomedical and pharmacological research continues to be replete with misunderstandings about whether animals have moral standing.


This article briefly reviews the central ethical positions and their relationship to the basic parameters of research regulation from an international perspective. The issues associated with the validation of animal models will then be discussed. Finally, suggestions for empirical ethics research will be presented.


Recent literature reviews were accessed and analyzed.


This review summarizes the pertinent ethical and research literature.


In summary, regardless of the ethical perspective one favors, there is strong agreement that animals matter morally and that at a minimum their welfare must be considered. This position is reflected in the structure of national regulatory schemes that emphasize the three Rs (replacement, reduction, refinement). Researchers should more actively participate in the discussion by becoming more knowledgeable about the details of the ethical issues. Research with animal models has been problematic in that it has often focused on attempting to produce global models of psychiatric disorders, which suffer from inherent validity problems. Researchers must also become more sophisticated about issues of model validation and the nature of the animals they use.


Ethics Psychopharmacology Animal research Animal models Validity Moral standing 


  1. Babkin BP (1938) Experimental neuroses in animals and their treatment with bromides. Edinb Med J 45:605–619Google Scholar
  2. Beauchamp T (1997) Opposing views on animal experimentation: do animals have rights? Ethics Behav 7:113–21Google Scholar
  3. Brody B (1998) The ethics of biomedical research: an international perspective. Oxford University Press, New YorkGoogle Scholar
  4. Cohen C (1986) The case for the use of animals in biomedical research. N Engl J Med 315:865–70Google Scholar
  5. De Grazia D (1991) The moral status of animals and their use in research: a philosophical review. Kennedy Inst Ethics J1:48–70Google Scholar
  6. Epling W (1989) Rats. Behav Anal 12:251–253Google Scholar
  7. Frey R (2002) Ethics, animals, and scientific inquiry. In: Gluck JP, DiPasquale T, Orlans FB (eds) Applied ethics in animal research: philosophy, regulation, and laboratory applications. Purdue, West Lafayette, pp 13–24Google Scholar
  8. Geyer MA, Markou A (1995) Animal models of psychiatric disorders. In Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 787–798Google Scholar
  9. Gluck JP (1997) Learning to see the animals again. In: Lafollette H (ed) Ethics in practice. Blackwell, London, pp 160–167Google Scholar
  10. Gluck JP, DiPasquale T (2002) Introduction and overview. In: Gluck JP DiPasquale T, Orlans FB (eds) Applied ethics in animal research: philosophy, regulation, and laboratory applications. Purdue, West Lafayette, pp 1–11Google Scholar
  11. Gluck JP, Kubacki SR (1991) Animals in biomedical research: the undermining effect of the rhetoric of the besieged. Ethics Behav 1:157–173PubMedGoogle Scholar
  12. Goodman S, Check E (2002) Animal experiments: the great primate debate. Nature 417:684–687CrossRefPubMedGoogle Scholar
  13. Griffin D (1981) The question of animal awareness. Rockefeller University, New YorkGoogle Scholar
  14. Griffin D (1984) Animal thinking. Harvard University, CambridgeGoogle Scholar
  15. Griffin D (1992) Animal minds. University of Chicago, ChicagoGoogle Scholar
  16. Harlow HF, Harlow MK, Suomi SJ (1971) From thought to therapy: lessons from a primate laboratory. Am Sci 59:538–549PubMedGoogle Scholar
  17. Hauser M (2000) Wild minds. Henry Holt, New YorkGoogle Scholar
  18. Kilts CD (2001) The changing roles and targets for animal models of schizophrenia. Biol Psychiatry 50:845-855PubMedGoogle Scholar
  19. Masserman JH (1946) Principles of dynamic psychiatry. Saunders, PhiladelphiaGoogle Scholar
  20. McClearn G (1979) Genetics and alcholism simulacra. Alcohol Clin Exp Res 3:255–258PubMedGoogle Scholar
  21. Midgeley M (1984) Animals and why they matter. University of Georgia Press, AthensGoogle Scholar
  22. Morrison A (2001) A scientist's perspective on the ethics of using animals in behavioral research. In: Carroll M, Overmier JB (2001) Animal research and human health. American Psychological Association, Washington D.C.Google Scholar
  23. Morrison A (2002) Developing an ethical view on the use of animals in biomedical research. Physiologist 45:135–144PubMedGoogle Scholar
  24. Orlans FB (2002) Ethical themes of the national regulations governing animal experiments: an international perspective. In: Gluck JP, DiPasquale T, Orlans FB (eds) Applied ethics in animal research: philosophy, regulation, and laboratory applications. Purdue University, West LafayetteGoogle Scholar
  25. Overall KL (1994) Use of clomipramine to treat ritualistic motor behavior in dogs. J Am Vet Assoc 205:1733–1741Google Scholar
  26. Regan T (1983) The case for animal rights. University of California, BerkeleyGoogle Scholar
  27. Roberts LW, Warner T, Brody J (2000) Perspectives of schizophrenia patients and psychiatrists regarding ethically important aspects of research participation. Am J Psychiatry 157:67–74PubMedGoogle Scholar
  28. Rollin B (1989) The unheeded cry: animal consciousness, animal pain and science. Oxford University, New YorkGoogle Scholar
  29. Russell W, Burch R (1959) The principles of humane experimental technique. Methuen, LondonGoogle Scholar
  30. Sapontzis S (1987) Morals, reasons and animals. Temple University, PhiladelphiaGoogle Scholar
  31. Shenger-Krestovnikova NR (1921) Contributions to the question of differentiation of visual stimuli and the limits of differentiation by the visual analyzer of the dog. Bull Lesgaft Inst Petrograd 3:1–43Google Scholar
  32. Singer P (1975) Animal liberation: a new ethics for the treatment of animals. New York Review, New YorkGoogle Scholar
  33. Singer P (1990) Animal liberation: a new ethics for the treatment of animals, 2nd edn. New York Review, New YorkGoogle Scholar
  34. Willner P (1995) Animal models of depression: validity and applications. In: Gessa G, Fratta W, Pani L, Serra G (eds) Depression and mania: from neurobiology to treatment. Raven, New York, pp 19–41Google Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Department of Psychology, Health Sciences Center Institute for EthicsUniversity of New MexicoAlbuquerqueUSA
  2. 2.Kennedy Institute of EthicsGeorgetown UniversityWashingtonUSA
  3. 3.Department of PsychologyUniversity of New MexicoAlbuquerqueUSA

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