Psychopharmacology

, Volume 167, Issue 2, pp 219–220 | Cite as

Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder

  • Vladimir Coric
  • Snezana Milanovic
  • Suzanne Wasylink
  • Pinal Patel
  • Robert Malison
  • John H. Krystal
Letter to the Editors

References

  1. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351–354PubMedGoogle Scholar
  2. Jehle T, Bauer J, Blauth E, Hummel A, Darstein M, Freiman TM, Feuerstein TJ (2000) Effects of riluzole on electrically evoked neurotransmitter release. Br J Pharmacol 130:1227–1234PubMedGoogle Scholar
  3. Krystal JH, D'Souza DC, Belger A, Anand A, Charney DS, Aghajanian GK, Moghaddam B (1999) Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists. Neuropsychopharmacology 22:S143–S157CrossRefGoogle Scholar
  4. Krystal JH, Sanacora G, Blumberg H, Anand, A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF (2002) Glutamate and GABA systems as targets for novel antidepressant and mood stabilizing treatments. Mol Psychiatry (in press)Google Scholar
  5. Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK (2000) Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. J Pharmacol Exp Ther 292:76–87Google Scholar
  6. Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ (2000) Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 39:1096–1103Google Scholar
  7. Stefani A, Spadoni F, Bernardi G (1997) Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies. Exp Neurol 147:115–122CrossRefGoogle Scholar
  8. Urbani A, Belluzzi O (2000) Riluzole inhibits the persistent sodium current in mammalian CNS neurons. Eur J Neurosci 12:3567–3574CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Vladimir Coric
    • 1
    • 2
  • Snezana Milanovic
    • 1
    • 2
  • Suzanne Wasylink
    • 1
    • 2
  • Pinal Patel
    • 1
    • 2
  • Robert Malison
    • 1
    • 2
  • John H. Krystal
    • 1
    • 2
    • 3
  1. 1.Clinical Neuroscience Research Unit, Abraham Ribicoff Research FacilitiesConnecticut Mental Health CenterNew HavenUSA
  2. 2.Department of PsychiatryYale University School of MedicineNew HavenUSA
  3. 3.Schizophrenia Biological Research CenterVA Connecticut Healthcare System (116-A)West HavenUSA

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