, Volume 168, Issue 1–2, pp 3–20 | Cite as

The reinstatement model of drug relapse: history, methodology and major findings

  • Yavin ShahamEmail author
  • Uri Shalev
  • Lin Lu
  • Harriet de Wit
  • Jane Stewart


Rational and objectives.

The reinstatement model is currently used in many laboratories to investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the history of the model and describe the different procedures that have been used to study the phenomenon of reinstatement of drug seeking. The results from studies using pharmacological and neuroanatomical techniques to determine the neuronal events that mediate reinstatement of heroin, cocaine and alcohol seeking by acute priming injections of drugs, drug-associated cues and environmental stressors are summarized. In addition, several issues are discussed, including (1) the concordance between the neuronal mechanisms involved in drug-induced reinstatement and those involved in drug reward and discrimination, (2) the role of drug withdrawal states and periods in reinstatement of drug seeking, (3) the role of neuronal adaptations induced by exposure to drugs in relapse, and (4) the degree to which the rat reinstatement model provides a suitable preclinical model of relapse to drug taking.


The data derived from studies using the reinstatement model suggest that the neuronal events that mediate drug-, cue- and stress-induced reinstatement of drug seeking are not identical, that the mechanisms underlying drug-induced reinstatement are to some degree different from those mediating drug discrimination or reward, and that the duration of the withdrawal period following cocaine and heroin self-administration has a profound effect on reinstatement induced by drug cues and stress. Finally, there appears to be a good correspondence between the events that induce reinstatement in laboratory animals and those that provoke relapse in humans.


Alcohol Cocaine Conditioned drug cues Extinction Heroin Reinstatement Relapse Review Reward Stress 



We thank Dr. Roger Spealman for providing Fig. 3.


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Copyright information

© Springer-Verlag  2003

Authors and Affiliations

  • Yavin Shaham
    • 1
    Email author
  • Uri Shalev
    • 1
  • Lin Lu
    • 1
  • Harriet de Wit
    • 2
  • Jane Stewart
    • 3
  1. 1.Behavioral Neuroscience Branch, NIDA/IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USAUSA
  2. 2.Department of Psychiatry, University of Chicago, Chicago, Ill., USAUSA
  3. 3.Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, CanadaCanada

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