Psychopharmacology

, Volume 162, Issue 1, pp 50–54

Significant pharmacokinetic interaction between risperidone and carbamazepine: its relationship with CYP2D6 genotypes

  • Shingo Ono
  • Kazuo Mihara
  • Akihito Suzuki
  • Tsuyoshi Kondo
  • Norio Yasui-Furukori
  • Hanako Furukori
  • Ronald de Vries
  • Sunao Kaneko
Original Investigation

DOI: 10.1007/s00213-002-1056-8

Cite this article as:
Ono, S., Mihara, K., Suzuki, A. et al. Psychopharmacology (2002) 162: 50. doi:10.1007/s00213-002-1056-8

Abstract.

The effects of carbamazepine coadministration (400 mg/day for 1 week) on plasma concentrations of risperidone and its active metabolite 9-hydroxyrisperidone were studied in 11 schizophrenic inpatients treated with 6 mg/day risperidone. Blood samplings were performed before and during carbamazepine coadministration, and 1 week after its discontinuation. Plasma concentrations of risperidone and 9-hydroxyrisperidone were measured using liquid chromatography–mass spectrometry–mass spectrometry. CYP2D6 genotypes were determined using the polymerase chain reaction method. Plasma concentrations of risperidone and 9-hydroxyrisperidone during carbamazepine coadministration (2.5±3.6 ng/ml and 19.4±4.1 ng/ml) were significantly (P<0.01) lower than those before carbamazepine coadministration (5.0±7.9 ng/ml and 34.6±9.8 ng/ml). The changes in risperidone concentrations were positively correlated to the concentration ratios of risperidone/9-hydroxyrisperidone (rs=0.90, P<0.01), which were closely associated with CYP2D6 genotypes. The present study suggests that carbamazepine induces the metabolism of risperidone and 9-hydroxyrisperidone, and that the decrease in risperidone concentration is dependent on the CYP2D6 activity.

Risperidone 9-Hydroxyrisperidone Carbamazepine Plasma concentration CYP2D6 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Shingo Ono
    • 1
  • Kazuo Mihara
    • 1
  • Akihito Suzuki
    • 1
  • Tsuyoshi Kondo
    • 1
  • Norio Yasui-Furukori
    • 1
  • Hanako Furukori
    • 1
  • Ronald de Vries
    • 2
  • Sunao Kaneko
    • 1
  1. 1.Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036-8562, JapanJapan
  2. 2.Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Beerse, BelgiumBelgium

Personalised recommendations