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Social behavior effects of diphenyl dimethyl bicarboxylate (DDB) in the sensory contact model

  • Amal M. MahfozEmail author
Original Article
  • 25 Downloads

Abstract

Sensory contact model (SCM) permits the evolution of diverse psychopathological states by the repeated antagonistic interactions between male mice. Biphenyl dimethyl dicarboxylate (DDB) is used as a hepatoprotective agent. The present work aimed to study the possible effects of DDB on social behavior developed by SCM by studying its effects on the transformation process to aggressive and submissive behaviors. Besides, measuring behavioral changes using the open field test (OFT) and the elevated plus maze test (EPM), neurochemical parameters [serotonin (5HT), norepqinephrine (NE), and dopamine(DA)], and immunological changes (total leucocyte count, differential leucocytic count, and evaluation of bone marrow lymphocytes count and viability assessment). Adult male Swiss mice were used; DDB was given in a dose of 100 mg/kg by oral gavage daily for 2 weeks from the fifth day to the last day of the SCM. The present study concluded that administration of DDB to the SCM involved animals was shown to be associated with significant positive impacts on the behavior of depressed partner in the SCM which were manifested by decreased latency and increased ambulation and rearing in OFT, increased number of entry in the open arm/total no of entries in EPM. This was associated with changes in brain levels of neurotransmitters which were manifested by increased NE and decreased DA, as well as the examined immunity related parameters which were manifested by increased total leucocyte count, bone marrow lymphocytes, and monocytes. So DDB can be used as a supportive antidepressant agent in patients with liver impairment and should be avoided in aggressive ones. However, more randomized controlled trials should be carried out to ascertain these effects.

Keywords

Sensory contact model DDB Social behavior 

Abbreviations

5-HT

Serotonin

CN

Control normal

CI

Control isolation

DA

Dopamine

DDB

Diphenyl dimethyl bicarboxylate

EPM

Elevated plus maze

NE

Norepinephrine

OFT

Open field test

Sw

Winner partner of the sensory contact model

Sw + Dp

Winner partner of the sensory contact model + DDB

Sw + Vp

Winner partner of the sensory contact model + DDB vehicle (vehicle control)

Sl

Loser partner of the sensory contact model

Sl + Dp

loser partner of the sensory contact model + DDB

Sl + Vp

Loser partner of the sensory contact model + DDB vehicle (vehicle control)

Notes

Author contribution

AM conceived and designed research, conducted experiments, analyzed the data, and wrote the manuscript.

Compliance with ethical standards

Ethics approval

All procedures performed in this study involving animals and their care were in accordance with the National Institute of Health’s ethical guidelines and approved by the bio & medical ethics committee of conducting scientific research; college of medicine; Umm Al Qura University; Saudi Arabia.

Conflict of interest

The author declare that she has no conflict of interest.

References

  1. Abdel-Hamid NM (2006) Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats. Afr J Biomed Res 9:77–81Google Scholar
  2. Ambavade SD et al (2006) Pharmacological evaluation of the extracts of Sphaeranthus indicus flowers on anxiolytic activity in mice. Indian J Pharmacol 38(4):254–259CrossRefGoogle Scholar
  3. Avgustinovich DF, Lipina TV, Molodtsova GF (1998) Changes in the activity of tryptophan hydroxylase and monoamine oxidase A during the development of experimental depression induced by social confrontations. Dokl Ros Akad Nauk 363:405–408Google Scholar
  4. Avgustinovich DF, Alekseenko OV, Bakshtanovskaia IV, Koriakina LA, Lipina TV, Tenditnik MV, Bondar’ NP, Kovalenko IL, Kudriavtseva NN (2004) Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study. Usp Fiziol Nauk 35(4):19–40PubMedGoogle Scholar
  5. Berk M, Williams LJ, Jacka FN, O’Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200.  https://doi.org/10.1186/1741-7015-11-200 CrossRefPubMedPubMedCentralGoogle Scholar
  6. Bernardi MM, Palermo-Neto J, De Souza H (1987) Effects of a single and along term haloperidol treatment on open field behavior in rats. Psychopharmacology 73:171–175CrossRefGoogle Scholar
  7. Bjorkqvist K (2001) Social defeat as a stressor in humans. Physiol Behav 73:435–442CrossRefGoogle Scholar
  8. Bloemena E, Weinreich S, Schellekens PT (1990) The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo. Clin Exp Immunol 80:460CrossRefGoogle Scholar
  9. Braat MC, Oosterhuis B, Koopmans RP (1992) Kinetic-dynamic modeling of lymphpcytopenia induced by the combined action of dexamethasone and hydrocortisone in humans, after inhalation and intravenous administration of dexamethasone. J Pharmacol Exp Ther 262:509PubMedGoogle Scholar
  10. Brown CH, Carbone PP (1971) Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro. Cancer Res 31:185–190PubMedGoogle Scholar
  11. Cancela LM, Basso AM, Martijena ID, Capriles NR, Molina VA (2001) A dopaminergic mechanism is involved in the ‘anxiogenic-like’ response induced by chronic amphetamine treatment: a behavioral and neurochemical study. Brain Res 909:179–186CrossRefGoogle Scholar
  12. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih J et al (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268(5218):1763–1766CrossRefGoogle Scholar
  13. Ciarlone AF (1978) Further modification of a fluorometric method for analyzing brain amines. Microchem J 23:9–12CrossRefGoogle Scholar
  14. Cunha JM, Masur J (1978) Evaluation of psychotropic drugs with a modified open field test. Pharmacol 16:259–267CrossRefGoogle Scholar
  15. Denmark A, Tien D, Wong K, Chung A, Cachat J, Goodspeed J, Grimes C, Elegante M, Suciu C, Elkhayat S, Bartels B, Jackson A, Rosenberg M, Chung KM, Badani H, Kadri F, Roy S, Tan J, Gaikwad S, Stewart A, Zapolsky I, Gilder T, Kalueff AV (2010) The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning. Behav Brain Res 208(2):553–559.  https://doi.org/10.1016/j.bbr.2009.12.041 CrossRefPubMedGoogle Scholar
  16. Dhabhar FS et al (1995) Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms. J Immunol 154:5511–5527PubMedGoogle Scholar
  17. Dorshkind K, Landreth KS (1992) Regulation of B cell differentiation by bone marrow stromal cells. Int J Cell Cloning 10:12–17CrossRefGoogle Scholar
  18. Gammie SC, Nelson RJ (2003) Maternal aggression is reduced in neuronal nitric oxide synthase-deficient mice. J Neurosci 19:8027–8035CrossRefGoogle Scholar
  19. Hamed MR et al (2004) Neurobehavioral effects of biphenyl dimethyl dicarboxylate in male mice. J Drug Res Egypt 25:148–155Google Scholar
  20. Hamed MR et al (2006) Immunomodulatory effects of dimethyl- 4, 4′- Dimethoxy- 5, 5, 5′, 6′- Dimethylene Dioxy Biphenyl- 2, 2′- Dicarboxylate. J Drug Res Egypt 27(1, 2):32–43Google Scholar
  21. Hamed MR, Huzayyin AA, Hassan WA (2008a) Influence of biphenyl dimethyl dicarboxylate on social play behavior of young rats. J Drug Res Egypt 29Google Scholar
  22. Hamed MR, Sayed HM, Ibrahim MK (2008b) Neurobehavioral effects of biphenyl dimethyl Dicarboxylate in rats. J Drug Res Egypt 29(1):31–48Google Scholar
  23. Heidel SM, MacWilliams PS, Baird WM, Dashwood WM, Buters JT, Gonzalez FJ, Larsen MC, Czuprynski CJ, Jefcoate CR (2000) Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12- dimethylbenz[a] anthracene. Cancer Res 60:3454–3460PubMedGoogle Scholar
  24. Hogg S (1996) A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav 54:21–30CrossRefGoogle Scholar
  25. Houwen B (2000) Blood film preparation and staining procedures. Lab Hematol 6:1–7Google Scholar
  26. Joo SS, Won TJ, Kim MJ, Hwang KW, Lee DI (2006) Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG22.2.15. Arch Pharm Res 29:405–411CrossRefGoogle Scholar
  27. Kalueff AV, Tuohimaa P (2004) Experimental modeling of anxiety and depression. Acta Neurobiol Exp (Wars) 64(4):439–448Google Scholar
  28. Khalifa MMA et al (1997) Effect of diazepam, yohimbine and their combinations on spontaneous locomotor activity as well as possible correlation to the level of brain neurotransmitters in rats. J Egypt Soc Toxicol 18:19–25Google Scholar
  29. Kudryatseva NN (2009) Sensory contact model: protocol, control, applications. Nature Precedings. Available from: http://hdl.handle.net/10101/npre.2009.3299.1
  30. Kudryavtseva NN (1991) The sensory contact model for the study of aggressive and submissive behaviors in male mice. Aggress Behav 17(5):285–291.  https://doi.org/10.1002/1098-2337(1991)17:5<285::AIDAB2480170505>3.0.CO;2-P CrossRefGoogle Scholar
  31. Kudryavtseva NN (1999) Agonistic behavior: model, experiment, perspectives. Ross Fiziol Zh Im I M Sechenova 85(1):67–83Google Scholar
  32. Kudryavtseva NN (2000) Agonistic behavior: a model, experimental studies, and perspectives. Neurosci Behav Physiol 30(3):293–305.  https://doi.org/10.1007/BF02471782 CrossRefPubMedGoogle Scholar
  33. Kudryavtseva NN (2006) Psychopathology of repeated aggression: a neurobiological aspect. In: Morgan JP (ed) Perspectives on the psychology of aggression. NOVA Science Publishers, Inc., New York, pp 35–64Google Scholar
  34. Kudryavtseva NN (ed) (2010) Sensory contact model: protocol, control, applications. Nova Science Publishers, Inc., New York, p 38Google Scholar
  35. Kudryavtseva NN, Avgustinovich DF (1998) Behavioral and physiological markers of experimental depression induced by social conflicts (DISC). Aggress Behav 24:271–286.  https://doi.org/10.1002/(SICI)1098-2337(1998)24:4<271::AIDAB3>3.0.CO;2-M CrossRefGoogle Scholar
  36. Kudryavtseva NN, Bakshtanovskaya IV, Avgustinovich DF (1997) Effects of repeated experience of aggression in daily confrontations on the individual and social behavior of male mice. Zh Vyssh Nerv Deiat Im I P Pavlova 47(1):86–97Google Scholar
  37. Kudryavtseva NN, Avgustinovich DF, Bakshtanovskaya IV, Koryakina LA, Alekseyenko OV, Lipina TV et al (2006) Experimental study of neurophysiological basis for hereditary predisposition to the development of depression: review. In: Kalueff AV (ed) Animal models of biological psychiatry. Nova Science Publishers, Inc., New York, pp 75–95Google Scholar
  38. Kulikov AV, Kozlachkova EY, Kudryavtseva NN, Popova NK (1995) Correlation between tryptophan hydroxylase activity in the brain and predisposition to pinch-induced catalepsy in mice. Pharmacol Biochem Behav 50(3):431–435.  https://doi.org/10.1016/0091-3057(94)00293-R CrossRefPubMedGoogle Scholar
  39. Lazarini CA, Florio JC, Lemonica IP, Bernardi MM (2001) Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity and striatal DA levels in male and female rats. Neurotoxicol Teratol 23:665–673CrossRefGoogle Scholar
  40. Line SW (1996) Effects of social reorganization on cellular immunity in male cynomolgus monkeys. Am J Primatol 39:235–249CrossRefGoogle Scholar
  41. Liu TY, Hwua YS, Chao TW, Chi CW (1995) Mechanistic study of the inhibition of aflatoxin b1-induced hepatotoxicity by dimethyl-4,4’-dimethoxy-5,6,5’,6’-dimethylenedioxybiphenyl-2,2’-dicarboxylate. Cancer Lett 89:201–205CrossRefGoogle Scholar
  42. Looser R (1982) In: Wircung Von Halluzinogene “Ciclazacil und psilocybin” aus das verhanten Von raccen in offen field und wohn – labyrinth. Dipol Biol ETHZurich, Zurich, pp 28Google Scholar
  43. Lu H, Li Y (2002) Effects of dimethyl diphenyl bicarboxylate on the metabolism and hepatotoxicity of aflatoxin B1 in rats. Yao Xue Xue Bao 37:753–757PubMedGoogle Scholar
  44. McKinney WT (1984) Animal models of depression: an overview. Psychiatr Dev 2(2):77–96PubMedGoogle Scholar
  45. Miyake K, Underhill CB, Lesley J, Kincade PW (1990) Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 172:69–75CrossRefGoogle Scholar
  46. Paterson A, Whitting PJ, Gray JA, Flint J, Dawson GR (2001) Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity. Psychopharmacol (Berlin) 154(4):336–342.  https://doi.org/10.1007/s002130000640 CrossRefGoogle Scholar
  47. Petitto JM, McNamara RK, Gendreau PL, Huang Z, Jackson AJ (1999) Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J Neurosci Res 56:441–446CrossRefGoogle Scholar
  48. Rygula R, Abumaria N, Flügge G, Fuchs E, Rüther E, Havemann-Reinecke U (2005) Anhedonia and motivational deficits in rats: impact of chronic social stress. Behav Brain Res 162:127–134CrossRefGoogle Scholar
  49. Sabry MF, Hamed MR, El Sayed ME (2014) Effect of biphenyl dimethyl dicarboxylate and fluoxetine on performance of normally-fed and protein malnourished psychologically stressed mice in elevated plus maze. Bulletin of Faculty of Pharmacy, Cairo University 52:51–61CrossRefGoogle Scholar
  50. Salama HM et al (2004) Effect of DDB monotherapy and in combination with amantadine hydrochloride and ribavirin in patients with chronic hepatitis C virus infection. Sci Med J ESCME 16(1)Google Scholar
  51. Sanderson RD et al (1992) Adhesion of B lymphoid (MPC-11) cells to type І collagen is mediated by integral membrane proteoglycan, syndecan. J Immunol 148:3902–3911PubMedGoogle Scholar
  52. Sandnabba NK (1996) Selective breeding for isolation-induced intermale aggression in mice: associated responses and environmental influences. Behav Genet 26(5):477–488CrossRefGoogle Scholar
  53. Sendecor GW, Cochran WG (1980) Statistical methods, 7th edn. Lowa State University, AmesGoogle Scholar
  54. Simmons A (1997) Hematology: A combined theoretical and technical approach, 2nd edn. Butterworth-Heineman, Oxford, pp 526–273Google Scholar
  55. Van den Buuse M, de Jong W (1989) Differential effect of dopaminergic drugs on open field behavior of spontaneously hypertensive rats and normotensive Wister-Kyoto rats. J Pharmacol Exp Ther 248(3):1189–1196PubMedGoogle Scholar
  56. Volosin M, Cancela L, Molina V (1988) Influence of adrenocorticotrophic hormone on the behavior in the swim test of rats treated chronically with desipramine. J Pharm Pharmacol 40:74–76CrossRefGoogle Scholar
  57. Wang C, Xu YQ (2008) Diphenyl dimethyl bicarboxylate in the treatment of viral hepatitis, adjuvant or curative? Gastroenterology Research 1(1):2–7.  https://doi.org/10.4021/gr2008.10.1231 CrossRefPubMedPubMedCentralGoogle Scholar
  58. Zeng KW, Zhang T, Fu H, Liu GX, Wang XM (2012) Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol 692(1–3):29–37CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacology and Toxicology, Faculty of MedicineUmm Al-Qura UniversityMakkahSaudi Arabia

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