Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 388, Issue 2, pp 143–152 | Cite as

Interaction between Nm23 and the tumor suppressor VHL

  • Chih-Hung Lin
  • Vincent Dammai
  • Boris Adryan
  • Tien Hsu
Original Article


Among the anti-tumor genes (tumor suppressors and metastasis suppressors), the von-Hippel Lindau gene and the Nm23 family of genes are among the more intriguing ones. Both are small (long and short forms of VHL are 30 and 19 kD, respectively, and Nm23 is ~17 kD), and both possess diverse molecular and cellular functions. Despite extensive studies, the entire spectra of functions and the molecular function-phenotype correlation of these two proteins have not been completely elucidated. In this report, we present data showing these two proteins interact physically. We also summarize and confirm the previous studies that demonstrated the endocytic function of these two genes and further show that the endocytic function of VHL is mediated through the activity of Nm23. These functional and molecular interactions are evolutionarily conserved from Drosophila to human.


von Hippel-Lindau Nm23 Endocytosis Tumor suppressor gene 



This work was supported by a grant from the National Institutes of Health, USA, # RO1CA109860, to T.H.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Chih-Hung Lin
    • 1
    • 4
  • Vincent Dammai
    • 3
  • Boris Adryan
    • 3
    • 5
  • Tien Hsu
    • 2
    • 4
  1. 1.Department of SurgeryCathay General HospitalTaipeiRepublic of China
  2. 2.Department of MedicineBoston University School of MedicineBostonUSA
  3. 3.Department of Pathology and Laboratory MedicineMedical University of South CarolinaCharlestonUSA
  4. 4.Graduate Institute of Systems Biology and BioinformaticsNational Central UniversityChung-liRepublic of China
  5. 5.Cambridge Systems Biology CenterTennis Court RoadCambridgeUK

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