Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 381, Issue 3, pp 187–193

Novel pharmacological approaches for antiarrhythmic therapy


DOI: 10.1007/s00210-009-0487-8

Cite this article as:
Ravens, U. Naunyn-Schmied Arch Pharmacol (2010) 381: 187. doi:10.1007/s00210-009-0487-8


Arrhythmias are caused by the perturbation of physiological impulse formation, impaired conduction, or disturbed electrical recovery. Currently available antiarrhythmic drugs—perhaps with exception of amiodarone—are not sufficiently effective and are burdened by cardiac and extracardiac side effects that may offset their therapeutic benefits. Detailed knowledge about electrical and structural remodelling may provide a better understanding of the mechanisms leading to generation and maintenance of arrhythmias especially in the setting of underlying heart disease and accompanying autonomic dysfunction. Thus, targets for new pharmacological interventions could include atrial-selective ion channels (e.g. atrial INa, IKur and IK,ACh), pathology-selective ion channels (constitutively active IK,ACh, TRP channels), ischemia-uncoupled gap junctions, proteins related to malfunctioning intracellular Ca2+ homeostasis (e.g. “leaky” ryanodine receptors, overactive Na+,Ca2+ exchanger) or risk factors for arrhythmias (“upstream” therapies). In ventricular arrhythmias implantable cardioverter-defibrillator devices rather than antiarrhythmic drugs are the safest treatment option. The domain for new approaches to drug treatment is atrial fibrillation.


Atrial and ventricular arrhythmia Electrical and structural remodelling Non-conventional cardiac ion channels 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyMedical Faculty Carl Gustav Carus, Dresden University of TechnologyDresdenGermany

Personalised recommendations