Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 376, Issue 5, pp 295–300

Acute treatment with low doses of memantine does not impair aversive, non-associative and recognition memory in rats

  • Gislaine Z. Réus
  • Samira S. Valvassori
  • Roberta A. Machado
  • Márcio R. Martins
  • Elaine C. Gavioli
  • João Quevedo
Original Article

Abstract

Memantine is a non-competitive N-methyl-d-aspartate receptor antagonist, which has been employed in the clinic as a neuroprotective agent for the treatment of several dementias, particularly Alzheimer’s disease. In this study, we evaluated pharmacological effects of the acute administration of memantine on memory process. Memory retention scores were evaluated in normal adult Wistar rats injected with saline and memantine (2, 5, 10, and 20 mg/kg, IP) and then subjected to the step-down inhibitory avoidance task, habitation to an open-field apparatus, and object recognition task. The treatment with higher doses of memantine (10 and 20 mg/kg) injected 60 min before or immediately after training-session impaired acquisition and retention of aversive memory in the inhibitory avoidance task. In addition, higher doses of memantine injected 60 min before the first open-field exposure also impaired habituation during the second exposure to the apparatus. No significant differences were observed in the performance of rats treated with memantine, in all doses tested, compared to saline-treated rats in the object recognition task. Notably, we observed that at 5 mg/kg, memantine increased spontaneous locomotion and exploration in the rat open-field test. In conclusion, present findings support the view that memantine at lower doses did not affect memory formation in normal rats, but at high doses memantine, induce hyperlocomotion, which could bias the interpretation of the animal behavior assessed in memory tests.

Keywords

Memantine NMDA receptor Habituation to an open field Inhibitory avoidance task Object recognition task 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Gislaine Z. Réus
    • 1
  • Samira S. Valvassori
    • 1
  • Roberta A. Machado
    • 2
  • Márcio R. Martins
    • 1
  • Elaine C. Gavioli
    • 1
  • João Quevedo
    • 1
  1. 1.Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciumaBrazil
  2. 2.Laboratorio de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciumaBrazil

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