Regulation of fatty acid transport: from transcriptional to posttranscriptional effects

  • Adrian ChabowskiEmail author
  • Jan Górski
  • Arend Bonen

Long-chain fatty acids (LCFA) are essential for many cellular functions. In metabolically active tissues such as heart and skeletal muscle their principal role is to supply oxidative substrates. LCFA serve also as structural components of various lipids and proteins, and function in intracellular signaling. Although LCFA can enter into the cells via simple diffusion (Hamilton and Kamp 1999; Hamilton et al. 2002), LCFA utilization is not simply a function of blood LCFA levels, as plasmalemmal LCFA transport has been shown to be regulated at the tissue level (Turcotte et al. 1994; Coburn et al. 2000; Hajri et al. 2001). In particular, the membrane proteins such as FAT/CD36, FABPpm and FATP’s were shown to facilitate LCFA movement across the plasma membranes in skeletal muscle as well as in heart (Bonen et al. 2002; Schaffer 2002). Fatty-acid transporters are regulated proteins whose expression is modulated through transcriptional and post-transcriptional mechanisms. Recently, it was...


Human Skeletal Muscle CD36 Deficiency Human Skeletal Muscle Cell Total Protein Expression LCFA Uptake 
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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of PhysiologyMedical University of BialystokBialystokPoland
  2. 2.Department of Human Health and Nutritional SciencesUniversity of GuelphGuelphCanada

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